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Pheromone-based communication influences the production of somatic extracellular vesicles in C. elegans

Author

Listed:
  • Agata Szczepańska

    (Polish Academy of Sciences)

  • Katarzyna Olek

    (International Institute of Molecular and Cell Biology in Warsaw)

  • Klaudia Kołodziejska

    (Polish Academy of Sciences)

  • Jingfang Yu

    (Cornell University)

  • Abdulrahman Tudu Ibrahim

    (Polish Academy of Sciences
    Warsaw University of Technology)

  • Laura Adamkiewicz

    (Polish Academy of Sciences)

  • Frank C. Schroeder

    (Cornell University)

  • Wojciech Pokrzywa

    (International Institute of Molecular and Cell Biology in Warsaw)

  • Michał Turek

    (Polish Academy of Sciences)

Abstract

Extracellular vesicles (EVs) are integral to numerous biological processes, yet it is unclear how environmental factors or interactions among individuals within a population affect EV-regulated systems. In Caenorhabditis elegans, the evolutionarily conserved large EVs, known as exophers, are part of a maternal somatic tissue resource management system. Consequently, the offspring of individuals exhibiting active exopher biogenesis (exophergenesis) develop faster. Our research focuses on unraveling the complex inter-tissue and social dynamics that govern exophergenesis. We found that ascr#10, the primary male pheromone, enhances exopher production in hermaphrodites, mediated by the G-protein-coupled receptor STR-173 in ASK sensory neurons. In contrast, pheromone produced by other hermaphrodites, ascr#3, diminishes exophergenesis within the population. This process is regulated via the neuropeptides FLP-8 and FLP-21, which originate from the URX and AQR/PQR/URX neurons, respectively. Our results reveal a regulatory network that controls the production of somatic EV by the nervous system in response to social signals.

Suggested Citation

  • Agata Szczepańska & Katarzyna Olek & Klaudia Kołodziejska & Jingfang Yu & Abdulrahman Tudu Ibrahim & Laura Adamkiewicz & Frank C. Schroeder & Wojciech Pokrzywa & Michał Turek, 2024. "Pheromone-based communication influences the production of somatic extracellular vesicles in C. elegans," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-47016-x
    DOI: 10.1038/s41467-024-47016-x
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    References listed on IDEAS

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    1. Jagan Srinivasan & Fatma Kaplan & Ramadan Ajredini & Cherian Zachariah & Hans T. Alborn & Peter E. A. Teal & Rabia U. Malik & Arthur S. Edison & Paul W. Sternberg & Frank C. Schroeder, 2008. "A blend of small molecules regulates both mating and development in Caenorhabditis elegans," Nature, Nature, vol. 454(7208), pages 1115-1118, August.
    2. Ilija Melentijevic & Marton L. Toth & Meghan L. Arnold & Ryan J. Guasp & Girish Harinath & Ken C. Nguyen & Daniel Taub & J. Alex Parker & Christian Neri & Christopher V. Gabel & David H. Hall & Monica, 2017. "C. elegans neurons jettison protein aggregates and mitochondria under neurotoxic stress," Nature, Nature, vol. 542(7641), pages 367-371, February.
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