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A blend of small molecules regulates both mating and development in Caenorhabditis elegans

Author

Listed:
  • Jagan Srinivasan

    (California Institute of Technology, 1200 E. California Boulevard, Pasadena, California 91125, USA)

  • Fatma Kaplan

    (Department of Biochemistry and Molecular Biology,
    McKnight Brain Institute,
    National High Magnetic Field Laboratory, University of Florida, PO Box 100245, Gainesville, Florida 32610-0245, USA)

  • Ramadan Ajredini

    (Department of Biochemistry and Molecular Biology,
    McKnight Brain Institute,
    National High Magnetic Field Laboratory, University of Florida, PO Box 100245, Gainesville, Florida 32610-0245, USA)

  • Cherian Zachariah

    (Department of Biochemistry and Molecular Biology,
    McKnight Brain Institute,
    National High Magnetic Field Laboratory, University of Florida, PO Box 100245, Gainesville, Florida 32610-0245, USA)

  • Hans T. Alborn

    (Center for Medical, Agricultural and Veterinary Entomology, USDA-ARS, 1600–1700 SW 23rd Drive, PO Box 14565, Gainesville, Florida 32604, USA)

  • Peter E. A. Teal

    (Center for Medical, Agricultural and Veterinary Entomology, USDA-ARS, 1600–1700 SW 23rd Drive, PO Box 14565, Gainesville, Florida 32604, USA)

  • Rabia U. Malik

    (Boyce Thompson Institute, Cornell University, Ithaca, New York 14853, USA)

  • Arthur S. Edison

    (Department of Biochemistry and Molecular Biology,
    McKnight Brain Institute,
    National High Magnetic Field Laboratory, University of Florida, PO Box 100245, Gainesville, Florida 32610-0245, USA)

  • Paul W. Sternberg

    (California Institute of Technology, 1200 E. California Boulevard, Pasadena, California 91125, USA)

  • Frank C. Schroeder

    (Boyce Thompson Institute, Cornell University, Ithaca, New York 14853, USA)

Abstract

Potent cocktail: multi-protein sex pheromones A Caltech team has discovered that a cocktail of three small molecules at low concentrations acts as the sex pheromone in the roundworm Caenorhabditis elegans, whereas at higher concentration two of these compounds induce a dormant larval state known as the dauer stage. Both sexual reproduction and dauer formation, a population control mechanism that increases larval lifespan and resilience, are major life history traits. The discovery that they are regulated by largely overlapping families of small molecules suggests an intimate linkage between these aspects of C. elegans life cycle, and relates to the general observation that, for many organisms, changes in fecundity and lifespan are inversely correlated.

Suggested Citation

  • Jagan Srinivasan & Fatma Kaplan & Ramadan Ajredini & Cherian Zachariah & Hans T. Alborn & Peter E. A. Teal & Rabia U. Malik & Arthur S. Edison & Paul W. Sternberg & Frank C. Schroeder, 2008. "A blend of small molecules regulates both mating and development in Caenorhabditis elegans," Nature, Nature, vol. 454(7208), pages 1115-1118, August.
    • Handle: RePEc:nat:nature:v:454:y:2008:i:7208:d:10.1038_nature07168
    DOI: 10.1038/nature07168
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    Cited by:

    1. Agata Szczepańska & Katarzyna Olek & Klaudia Kołodziejska & Jingfang Yu & Abdulrahman Tudu Ibrahim & Laura Adamkiewicz & Frank C. Schroeder & Wojciech Pokrzywa & Michał Turek, 2024. "Pheromone-based communication influences the production of somatic extracellular vesicles in C. elegans," Nature Communications, Nature, vol. 15(1), pages 1-19, December.

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