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C. elegans neurons jettison protein aggregates and mitochondria under neurotoxic stress

Author

Listed:
  • Ilija Melentijevic

    (Nelson Biological Laboratories, Rutgers, The State University of New Jersey)

  • Marton L. Toth

    (Nelson Biological Laboratories, Rutgers, The State University of New Jersey)

  • Meghan L. Arnold

    (Nelson Biological Laboratories, Rutgers, The State University of New Jersey)

  • Ryan J. Guasp

    (Nelson Biological Laboratories, Rutgers, The State University of New Jersey)

  • Girish Harinath

    (Nelson Biological Laboratories, Rutgers, The State University of New Jersey)

  • Ken C. Nguyen

    (Albert Einstein College of Medicine)

  • Daniel Taub

    (Boston University School of Medicine
    Boston University Photonics Center)

  • J. Alex Parker

    (Université de Montréal CRCHUM)

  • Christian Neri

    (CNRS, UMR 8256, Brain-C team, Paris, France, and Sorbonnes Universités, University Pierre and Marie Curie (UPMC) Univ Paris 06)

  • Christopher V. Gabel

    (Boston University School of Medicine
    Boston University Photonics Center)

  • David H. Hall

    (Albert Einstein College of Medicine)

  • Monica Driscoll

    (Nelson Biological Laboratories, Rutgers, The State University of New Jersey)

Abstract

Adult neurons from Caenorhabditis elegans can extrude large membrane-surrounded vesicles, known as exophers, containing protein aggregates and dysfunctional organelles that threaten neuronal homeostasis.

Suggested Citation

  • Ilija Melentijevic & Marton L. Toth & Meghan L. Arnold & Ryan J. Guasp & Girish Harinath & Ken C. Nguyen & Daniel Taub & J. Alex Parker & Christian Neri & Christopher V. Gabel & David H. Hall & Monica, 2017. "C. elegans neurons jettison protein aggregates and mitochondria under neurotoxic stress," Nature, Nature, vol. 542(7641), pages 367-371, February.
    • Handle: RePEc:nat:nature:v:542:y:2017:i:7641:d:10.1038_nature21362
    DOI: 10.1038/nature21362
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    Citations

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    Cited by:

    1. Georgia K. Atkin-Smith & Jascinta P. Santavanond & Amanda Light & Joel S. Rimes & Andre L. Samson & Jeremy Er & Joy Liu & Darryl N. Johnson & Mélanie Le Page & Pradeep Rajasekhar & Raymond K. H. Yip &, 2024. "In situ visualization of endothelial cell-derived extracellular vesicle formation in steady state and malignant conditions," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    2. Arthur Fischbach & Angela Johns & Kara L. Schneider & Xinxin Hao & Peter Tessarz & Thomas Nyström, 2023. "Artificial Hsp104-mediated systems for re-localizing protein aggregates," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    3. Meghan Lee Arnold & Jason Cooper & Rebecca Androwski & Sohil Ardeshna & Ilija Melentijevic & Joelle Smart & Ryan J. Guasp & Ken C. Q. Nguyen & Ge Bai & David H. Hall & Barth D. Grant & Monica Driscoll, 2023. "Intermediate filaments associate with aggresome-like structures in proteostressed C. elegans neurons and influence large vesicle extrusions as exophers," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    4. Wang Yuan & Yi M. Weaver & Svetlana Earnest & Clinton A. Taylor & Melanie H. Cobb & Benjamin P. Weaver, 2023. "Modulating p38 MAPK signaling by proteostasis mechanisms supports tissue integrity during growth and aging," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    5. Lasse Dissing-Olesen & Alec J. Walker & Qian Feng & Helena J. Barr & Alicia C. Walker & Lili Xie & Daniel K. Wilton & Indrani Das & Larry I. Benowitz & Beth Stevens, 2023. "FEAST: A flow cytometry-based toolkit for interrogating microglial engulfment of synaptic and myelin proteins," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    6. Hayden Weng Siong Tan & Guang Lu & Han Dong & Yik-Lam Cho & Auginia Natalia & Liming Wang & Charlene Chan & Dennis Kappei & Reshma Taneja & Shuo-Chien Ling & Huilin Shao & Shih-Yin Tsai & Wen-Xing Din, 2022. "A degradative to secretory autophagy switch mediates mitochondria clearance in the absence of the mATG8-conjugation machinery," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    7. Qiang Zhu & Matthew E. Combs & Juan Liu & Xue Bai & Wenbo B. Wang & Laura E. Herring & Jiandong Liu & Jason W. Locasale & Dawn E. Bowles & Ryan T. Gross & Michelle Mendiola Pla & Christopher P. Mack &, 2023. "GRAF1 integrates PINK1-Parkin signaling and actin dynamics to mediate cardiac mitochondrial homeostasis," Nature Communications, Nature, vol. 14(1), pages 1-21, December.
    8. Agata Szczepańska & Katarzyna Olek & Klaudia Kołodziejska & Jingfang Yu & Abdulrahman Tudu Ibrahim & Laura Adamkiewicz & Frank C. Schroeder & Wojciech Pokrzywa & Michał Turek, 2024. "Pheromone-based communication influences the production of somatic extracellular vesicles in C. elegans," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    9. Wenjing Liang & Shakti Sagar & Rishith Ravindran & Rita H. Najor & Justin M. Quiles & Liguo Chi & Rachel Y. Diao & Benjamin P. Woodall & Leonardo J. Leon & Erika Zumaya & Jason Duran & David M. Cauvi , 2023. "Mitochondria are secreted in extracellular vesicles when lysosomal function is impaired," Nature Communications, Nature, vol. 14(1), pages 1-18, December.

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