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Quantifying how single dose Ad26.COV2.S vaccine efficacy depends on Spike sequence features

Author

Listed:
  • Craig A. Magaret

    (Fred Hutchinson Cancer Center)

  • Li Li

    (Fred Hutchinson Cancer Center)

  • Allan C. deCamp

    (Fred Hutchinson Cancer Center)

  • Morgane Rolland

    (Walter Reed Army Institute of Research
    Inc)

  • Michal Juraska

    (Fred Hutchinson Cancer Center)

  • Brian D. Williamson

    (Fred Hutchinson Cancer Center
    Kaiser Permanente Washington Health Research Institute)

  • James Ludwig

    (Fred Hutchinson Cancer Center)

  • Cindy Molitor

    (Fred Hutchinson Cancer Center)

  • David Benkeser

    (Emory University)

  • Alex Luedtke

    (University of Washington)

  • Brian Simpkins

    (Pitzer College)

  • Fei Heng

    (University of North Florida)

  • Yanqing Sun

    (University of North Carolina at Charlotte)

  • Lindsay N. Carpp

    (Fred Hutchinson Cancer Center)

  • Hongjun Bai

    (Walter Reed Army Institute of Research
    Inc)

  • Bethany L. Dearlove

    (Walter Reed Army Institute of Research
    Inc)

  • Elena E. Giorgi

    (Fred Hutchinson Cancer Center)

  • Mandy Jongeneelen

    (Janssen Vaccines & Prevention B.V)

  • Boerries Brandenburg

    (Janssen Vaccines & Prevention B.V)

  • Matthew McCallum

    (University of Washington)

  • John E. Bowen

    (University of Washington)

  • David Veesler

    (University of Washington
    University of Washington)

  • Jerald Sadoff

    (Janssen Vaccines & Prevention B.V)

  • Glenda E. Gray

    (University of the Witwatersrand
    South African Medical Research Council)

  • Sanne Roels

    (a division of Janssen Pharmaceutica NV)

  • An Vandebosch

    (a division of Janssen Pharmaceutica NV)

  • Daniel J. Stieh

    (Janssen Vaccines & Prevention B.V)

  • Mathieu Gars

    (Janssen Vaccines & Prevention B.V)

  • Johan Vingerhoets

    (a division of Janssen Pharmaceutica NV)

  • Beatriz Grinsztejn

    (Evandro Chagas National Institute of Infectious Diseases-Fundação Oswaldo Cruz)

  • Paul A. Goepfert

    (University of Alabama at Birmingham)

  • Leonardo Paiva Sousa

    (Evandro Chagas National Institute of Infectious Diseases-Fundação Oswaldo Cruz)

  • Mayara Secco Torres Silva

    (Evandro Chagas National Institute of Infectious Diseases-Fundação Oswaldo Cruz)

  • Martin Casapia

    (Universidad Nacional de la Amazonia Peru)

  • Marcelo H. Losso

    (Hospital General de Agudos José María Ramos Mejia)

  • Susan J. Little

    (University of California San Diego)

  • Aditya Gaur

    (St. Jude Children’s Research Hospital)

  • Linda-Gail Bekker

    (Observatory)

  • Nigel Garrett

    (University of KwaZulu-Natal
    University of KwaZulu-Natal)

  • Carla Truyers

    (a division of Janssen Pharmaceutica NV)

  • Ilse Dromme

    (a division of Janssen Pharmaceutica NV)

  • Edith Swann

    (National Institutes of Health)

  • Mary A. Marovich

    (National Institutes of Health)

  • Dean Follmann

    (National Institutes of Health)

  • Kathleen M. Neuzil

    (University of Maryland School of Medicine)

  • Lawrence Corey

    (Fred Hutchinson Cancer Center
    University of Washington)

  • Alexander L. Greninger

    (Fred Hutchinson Cancer Center
    University of Washington)

  • Pavitra Roychoudhury

    (Fred Hutchinson Cancer Center
    University of Washington)

  • Ollivier Hyrien

    (Fred Hutchinson Cancer Center)

  • Peter B. Gilbert

    (Fred Hutchinson Cancer Center
    Fred Hutchinson Cancer Center
    University of Washington School of Public Health)

Abstract

In the ENSEMBLE randomized, placebo-controlled phase 3 trial (NCT04505722), estimated single-dose Ad26.COV2.S vaccine efficacy (VE) was 56% against moderate to severe–critical COVID-19. SARS-CoV-2 Spike sequences were determined from 484 vaccine and 1,067 placebo recipients who acquired COVID-19. In this set of prespecified analyses, we show that in Latin America, VE was significantly lower against Lambda vs. Reference and against Lambda vs. non-Lambda [family-wise error rate (FWER) p

Suggested Citation

  • Craig A. Magaret & Li Li & Allan C. deCamp & Morgane Rolland & Michal Juraska & Brian D. Williamson & James Ludwig & Cindy Molitor & David Benkeser & Alex Luedtke & Brian Simpkins & Fei Heng & Yanqing, 2024. "Quantifying how single dose Ad26.COV2.S vaccine efficacy depends on Spike sequence features," Nature Communications, Nature, vol. 15(1), pages 1-22, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-46536-w
    DOI: 10.1038/s41467-024-46536-w
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    References listed on IDEAS

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