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A cerebro-cerebellar network for learning visuomotor associations

Author

Listed:
  • Naveen Sendhilnathan

    (Columbia University
    Columbia University)

  • Andreea C. Bostan

    (University of Pittsburgh)

  • Peter L. Strick

    (University of Pittsburgh)

  • Michael E. Goldberg

    (Columbia University
    Columbia University
    Columbia University College of Physicians and Surgeons)

Abstract

Consensus is rapidly building to support a role for the cerebellum beyond motor function, but its contributions to non-motor learning remain poorly understood. Here, we provide behavioral, anatomical and computational evidence to demonstrate a causal role for the primate posterior lateral cerebellum in learning new visuomotor associations. Reversible inactivation of the posterior lateral cerebellum of male monkeys impeded the learning of new visuomotor associations, but had no effect on movement parameters, or on well-practiced performance of the same task. Using retrograde transneuronal transport of rabies virus, we identified a distinct cerebro-cerebellar network linking Purkinje cells in the posterior lateral cerebellum with a region of the prefrontal cortex that is critical in learning visuomotor associations. Together, these results demonstrate a causal role for the primate posterior lateral cerebellum in non-motor, reinforcement learning.

Suggested Citation

  • Naveen Sendhilnathan & Andreea C. Bostan & Peter L. Strick & Michael E. Goldberg, 2024. "A cerebro-cerebellar network for learning visuomotor associations," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-46281-0
    DOI: 10.1038/s41467-024-46281-0
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    References listed on IDEAS

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