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The long and winding road of reprogramming-induced rejuvenation

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  • Ali Doğa Yücel

    (Koc University
    Harvard Medical School)

  • Vadim N. Gladyshev

    (Harvard Medical School)

Abstract

Organismal aging is inherently connected to the aging of its constituent cells and systems. Reducing the biological age of the organism may be assisted by reducing the age of its cells - an approach exemplified by partial cell reprogramming through the expression of Yamanaka factors or exposure to chemical cocktails. It is crucial to protect cell type identity during partial reprogramming, as cells need to retain or rapidly regain their functions following the treatment. Another critical issue is the ability to quantify biological age as reprogrammed older cells acquire younger states. We discuss recent advances in reprogramming-induced rejuvenation and offer a critical review of this procedure and its relationship to the fundamental nature of aging. We further comparatively analyze partial reprogramming, full reprogramming and transdifferentiation approaches, assess safety concerns and emphasize the importance of distinguishing rejuvenation from dedifferentiation. Finally, we highlight translational opportunities that the reprogramming-induced rejuvenation approach offers.

Suggested Citation

  • Ali Doğa Yücel & Vadim N. Gladyshev, 2024. "The long and winding road of reprogramming-induced rejuvenation," Nature Communications, Nature, vol. 15(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-46020-5
    DOI: 10.1038/s41467-024-46020-5
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    1. Chao Wang & Ruben Rabadan Ros & Paloma Martinez-Redondo & Zaijun Ma & Lei Shi & Yuan Xue & Isabel Guillen-Guillen & Ling Huang & Tomoaki Hishida & Hsin-Kai Liao & Estrella Nuñez Delicado & Concepcion , 2021. "In vivo partial reprogramming of myofibers promotes muscle regeneration by remodeling the stem cell niche," Nature Communications, Nature, vol. 12(1), pages 1-15, December.
    2. María Abad & Lluc Mosteiro & Cristina Pantoja & Marta Cañamero & Teresa Rayon & Inmaculada Ors & Osvaldo Graña & Diego Megías & Orlando Domínguez & Dolores Martínez & Miguel Manzanares & Sagrario Orte, 2013. "Reprogramming in vivo produces teratomas and iPS cells with totipotency features," Nature, Nature, vol. 502(7471), pages 340-345, October.
    3. Jingyang Guan & Guan Wang & Jinlin Wang & Zhengyuan Zhang & Yao Fu & Lin Cheng & Gaofan Meng & Yulin Lyu & Jialiang Zhu & Yanqin Li & Yanglu Wang & Shijia Liuyang & Bei Liu & Zirun Yang & Huanjing He , 2022. "Chemical reprogramming of human somatic cells to pluripotent stem cells," Nature, Nature, vol. 605(7909), pages 325-331, May.
    4. Stuart D. Tyner & Sundaresan Venkatachalam & Jene Choi & Stephen Jones & Nader Ghebranious & Herbert Igelmann & Xiongbin Lu & Gabrielle Soron & Benjamin Cooper & Cory Brayton & Sang Hee Park & Timothy, 2002. "p53 mutant mice that display early ageing-associated phenotypes," Nature, Nature, vol. 415(6867), pages 45-53, January.
    5. Yuancheng Lu & Benedikt Brommer & Xiao Tian & Anitha Krishnan & Margarita Meer & Chen Wang & Daniel L. Vera & Qiurui Zeng & Doudou Yu & Michael S. Bonkowski & Jae-Hyun Yang & Songlin Zhou & Emma M. Ho, 2020. "Reprogramming to recover youthful epigenetic information and restore vision," Nature, Nature, vol. 588(7836), pages 124-129, December.
    6. Hyenjong Hong & Kazutoshi Takahashi & Tomoko Ichisaka & Takashi Aoi & Osami Kanagawa & Masato Nakagawa & Keisuke Okita & Shinya Yamanaka, 2009. "Suppression of induced pluripotent stem cell generation by the p53–p21 pathway," Nature, Nature, vol. 460(7259), pages 1132-1135, August.
    7. Chao Sheng & Johannes Jungverdorben & Hendrik Wiethoff & Qiong Lin & Lea J. Flitsch & Daniela Eckert & Matthias Hebisch & Julia Fischer & Jaideep Kesavan & Beatrice Weykopf & Linda Schneider & Dominik, 2018. "A stably self-renewing adult blood-derived induced neural stem cell exhibiting patternability and epigenetic rejuvenation," Nature Communications, Nature, vol. 9(1), pages 1-15, December.
    8. Tapash Jay Sarkar & Marco Quarta & Shravani Mukherjee & Alex Colville & Patrick Paine & Linda Doan & Christopher M. Tran & Constance R. Chu & Steve Horvath & Lei S. Qi & Nidhi Bhutani & Thomas A. Rand, 2020. "Transient non-integrative expression of nuclear reprogramming factors promotes multifaceted amelioration of aging in human cells," Nature Communications, Nature, vol. 11(1), pages 1-12, December.
    9. Tamer T. Onder & Nergis Kara & Anne Cherry & Amit U. Sinha & Nan Zhu & Kathrin M. Bernt & Patrick Cahan & B. Ogan Mancarci & Juli Unternaehrer & Piyush B. Gupta & Eric S. Lander & Scott A. Armstrong &, 2012. "Chromatin-modifying enzymes as modulators of reprogramming," Nature, Nature, vol. 483(7391), pages 598-602, March.
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