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Epidemiology of Δ8THC-Related Carcinogenesis in USA: A Panel Regression and Causal Inferential Study

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  • Albert Stuart Reece

    (Division of Psychiatry, University of Western Australia, Crawley, WA 6009, Australia
    School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA 6027, Australia)

  • Gary Kenneth Hulse

    (Division of Psychiatry, University of Western Australia, Crawley, WA 6009, Australia
    School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA 6027, Australia)

Abstract

The use of Δ8THC is increasing at present across the USA in association with widespread cannabis legalization and the common notion that it is “legal weed”. As genotoxic actions have been described for many cannabinoids, we studied the cancer epidemiology of Δ8THC. Data on 34 cancer types was from the Centers for Disease Control Atlanta Georgia, substance abuse data from the Substance Abuse and Mental Health Services Administration, ethnicity and income data from the U.S. Census Bureau, and cannabinoid concentration data from the Drug Enforcement Agency, were combined and processed in R. Eight cancers (corpus uteri, liver, gastric cardia, breast and post-menopausal breast, anorectum, pancreas, and thyroid) were related to Δ8THC exposure on bivariate testing, and 18 (additionally, stomach, Hodgkins, and Non-Hodgkins lymphomas, ovary, cervix uteri, gall bladder, oropharynx, bladder, lung, esophagus, colorectal cancer, and all cancers (excluding non-melanoma skin cancer)) demonstrated positive average marginal effects on fully adjusted inverse probability weighted interactive panel regression. Many minimum E-Values (mEVs) were infinite. p -values rose from 8.04 × 10 −78 . Marginal effect calculations revealed that 18 Δ8THC-related cancers are predicted to lead to a further 8.58 cases/100,000 compared to 7.93 for alcoholism and −8.48 for tobacco. Results indicate that between 8 and 20/34 cancer types were associated with Δ8THC exposure, with very high effect sizes (mEVs) and marginal effects after adjustment exceeding tobacco and alcohol, fulfilling the epidemiological criteria of causality and suggesting a cannabinoid class effect. The inclusion of pediatric leukemias and testicular cancer herein demonstrates heritable malignant teratogenesis.

Suggested Citation

  • Albert Stuart Reece & Gary Kenneth Hulse, 2022. "Epidemiology of Δ8THC-Related Carcinogenesis in USA: A Panel Regression and Causal Inferential Study," IJERPH, MDPI, vol. 19(13), pages 1-27, June.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:13:p:7726-:d:846330
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    1. Xiaotu Ma & Yu Liu & Yanling Liu & Ludmil B. Alexandrov & Michael N. Edmonson & Charles Gawad & Xin Zhou & Yongjin Li & Michael C. Rusch & John Easton & Robert Huether & Veronica Gonzalez-Pena & Mark , 2018. "Pan-cancer genome and transcriptome analyses of 1,699 paediatric leukaemias and solid tumours," Nature, Nature, vol. 555(7696), pages 371-376, March.
    2. Etienne Hebert-Chatelain & Tifany Desprez & Román Serrat & Luigi Bellocchio & Edgar Soria-Gomez & Arnau Busquets-Garcia & Antonio Christian Pagano Zottola & Anna Delamarre & Astrid Cannich & Peggy Vin, 2016. "A cannabinoid link between mitochondria and memory," Nature, Nature, vol. 539(7630), pages 555-559, November.
    3. Susanne N. Gröbner & Barbara C. Worst & Joachim Weischenfeldt & Ivo Buchhalter & Kortine Kleinheinz & Vasilisa A. Rudneva & Pascal D. Johann & Gnana Prakash Balasubramanian & Maia Segura-Wang & Sebast, 2018. "The landscape of genomic alterations across childhood cancers," Nature, Nature, vol. 555(7696), pages 321-327, March.
    4. Julie George & Jing Shan Lim & Se Jin Jang & Yupeng Cun & Luka Ozretić & Gu Kong & Frauke Leenders & Xin Lu & Lynnette Fernández-Cuesta & Graziella Bosco & Christian Müller & Ilona Dahmen & Nadine S. , 2015. "Comprehensive genomic profiles of small cell lung cancer," Nature, Nature, vol. 524(7563), pages 47-53, August.
    5. Kseniia Cheloshkina & Maria Poptsova, 2021. "Comprehensive analysis of cancer breakpoints reveals signatures of genetic and epigenetic contribution to cancer genome rearrangements," PLOS Computational Biology, Public Library of Science, vol. 17(3), pages 1-23, March.
    6. Yuancheng Lu & Benedikt Brommer & Xiao Tian & Anitha Krishnan & Margarita Meer & Chen Wang & Daniel L. Vera & Qiurui Zeng & Doudou Yu & Michael S. Bonkowski & Jae-Hyun Yang & Songlin Zhou & Emma M. Ho, 2020. "Reprogramming to recover youthful epigenetic information and restore vision," Nature, Nature, vol. 588(7836), pages 124-129, December.
    7. van der Wal, Willem M. & Geskus, Ronald B., 2011. "ipw: An R Package for Inverse Probability Weighting," Journal of Statistical Software, Foundation for Open Access Statistics, vol. 43(i13).
    8. Susanne N. Gröbner & Barbara C. Worst & Joachim Weischenfeldt & Ivo Buchhalter & Kortine Kleinheinz & Vasilisa A. Rudneva & Pascal D. Johann & Gnana Prakash Balasubramanian & Maia Segura-Wang & Sebast, 2018. "Author Correction: The landscape of genomic alterations across childhood cancers," Nature, Nature, vol. 559(7714), pages 10-10, July.
    9. Cheng-Zhong Zhang & Alexander Spektor & Hauke Cornils & Joshua M. Francis & Emily K. Jackson & Shiwei Liu & Matthew Meyerson & David Pellman, 2015. "Chromothripsis from DNA damage in micronuclei," Nature, Nature, vol. 522(7555), pages 179-184, June.
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