IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v415y2002i6867d10.1038_415045a.html
   My bibliography  Save this article

p53 mutant mice that display early ageing-associated phenotypes

Author

Listed:
  • Stuart D. Tyner

    (Cell and Molecular Biology Program)

  • Sundaresan Venkatachalam

    (Department of Molecular Virology and Microbiology)

  • Jene Choi

    (Department of Molecular Virology and Microbiology)

  • Stephen Jones

    (University of Massachusetts Medical Center)

  • Nader Ghebranious

    (Marshfield Medical Research Foundation)

  • Herbert Igelmann

    (Heinrich-Pette-Institut für Experimentelle Virologie und Immunologie an der Universitat Hamburg)

  • Xiongbin Lu

    (Department of Molecular Virology and Microbiology)

  • Gabrielle Soron

    (Department of Molecular Virology and Microbiology)

  • Benjamin Cooper

    (Department of Molecular Virology and Microbiology)

  • Cory Brayton

    (Center for Comparative Medicine)

  • Sang Hee Park

    (Scott Department of Urology)

  • Timothy Thompson

    (Scott Department of Urology)

  • Gerard Karsenty

    (Department of Human and Molecular Genetics
    The Sanger Centre, Wellcome Trust Genome Campus)

  • Allan Bradley

    (Department of Human and Molecular Genetics
    The Sanger Centre, Wellcome Trust Genome Campus)

  • Lawrence A. Donehower

    (Department of Molecular Virology and Microbiology
    Baylor College of Medicine)

Abstract

The p53 tumour suppressor is activated by numerous stressors to induce apoptosis, cell cycle arrest, or senescence. To study the biological effects of altered p53 function, we generated mice with a deletion mutation in the first six exons of the p53 gene that express a truncated RNA capable of encoding a carboxy-terminal p53 fragment. This mutation confers phenotypes consistent with activated p53 rather than inactivated p53. Mutant (p53+/m) mice exhibit enhanced resistance to spontaneous tumours compared with wild-type (p53+/+) littermates. As p53+/m mice age, they display an early onset of phenotypes associated with ageing. These include reduced longevity, osteoporosis, generalized organ atrophy and a diminished stress tolerance. A second line of transgenic mice containing a temperature-sensitive mutant allele of p53 also exhibits early ageing phenotypes. These data suggest that p53 has a role in regulating organismal ageing.

Suggested Citation

  • Stuart D. Tyner & Sundaresan Venkatachalam & Jene Choi & Stephen Jones & Nader Ghebranious & Herbert Igelmann & Xiongbin Lu & Gabrielle Soron & Benjamin Cooper & Cory Brayton & Sang Hee Park & Timothy, 2002. "p53 mutant mice that display early ageing-associated phenotypes," Nature, Nature, vol. 415(6867), pages 45-53, January.
    • Handle: RePEc:nat:nature:v:415:y:2002:i:6867:d:10.1038_415045a
    DOI: 10.1038/415045a
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/415045a
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/415045a?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Huiru Bai & Xiaoqin Liu & Meizhen Lin & Yuan Meng & Ruolan Tang & Yajing Guo & Nan Li & Michael F. Clarke & Shang Cai, 2024. "Progressive senescence programs induce intrinsic vulnerability to aging-related female breast cancer," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    2. Ali Doğa Yücel & Vadim N. Gladyshev, 2024. "The long and winding road of reprogramming-induced rejuvenation," Nature Communications, Nature, vol. 15(1), pages 1-9, December.
    3. Jean-Philippe Coppé & Christopher K Patil & Francis Rodier & Yu Sun & Denise P Muñoz & Joshua Goldstein & Peter S Nelson & Pierre-Yves Desprez & Judith Campisi, 2008. "Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor," PLOS Biology, Public Library of Science, vol. 6(12), pages 1-1, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:415:y:2002:i:6867:d:10.1038_415045a. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.