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Chromatin-modifying enzymes as modulators of reprogramming

Author

Listed:
  • Tamer T. Onder

    (Stem Cell Transplantation Program, Manton Center for Orphan Disease Research, Children’s Hospital Boston and Dana Farber Cancer Institute
    Harvard Medical School
    Harvard Stem Cell Institute, Cambridge
    Stem Cell Program, Children’s Hospital Boston)

  • Nergis Kara

    (German Cancer Research Center, Heidelberg, 69120, Germany)

  • Anne Cherry

    (Stem Cell Transplantation Program, Manton Center for Orphan Disease Research, Children’s Hospital Boston and Dana Farber Cancer Institute
    Harvard Medical School
    Harvard Stem Cell Institute, Cambridge
    Stem Cell Program, Children’s Hospital Boston)

  • Amit U. Sinha

    (Children’s Hospital, Harvard Medical School
    Harvard Medical School)

  • Nan Zhu

    (Harvard Stem Cell Institute, Cambridge
    Children’s Hospital, Harvard Medical School
    Harvard Medical School)

  • Kathrin M. Bernt

    (Harvard Stem Cell Institute, Cambridge
    Children’s Hospital, Harvard Medical School
    Harvard Medical School)

  • Patrick Cahan

    (Stem Cell Transplantation Program, Manton Center for Orphan Disease Research, Children’s Hospital Boston and Dana Farber Cancer Institute
    Harvard Medical School
    Harvard Stem Cell Institute, Cambridge
    Stem Cell Program, Children’s Hospital Boston)

  • B. Ogan Mancarci

    (Bilkent University)

  • Juli Unternaehrer

    (Stem Cell Transplantation Program, Manton Center for Orphan Disease Research, Children’s Hospital Boston and Dana Farber Cancer Institute
    Harvard Medical School
    Harvard Stem Cell Institute, Cambridge
    Stem Cell Program, Children’s Hospital Boston)

  • Piyush B. Gupta

    (Massachusetts Institute of Technology
    Whitehead Institute for Biomedical Research, Cambridge)

  • Eric S. Lander

    (Massachusetts Institute of Technology
    The Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge
    Harvard Medical School)

  • Scott A. Armstrong

    (Harvard Stem Cell Institute, Cambridge
    Children’s Hospital, Harvard Medical School
    Harvard Medical School)

  • George Q. Daley

    (Stem Cell Transplantation Program, Manton Center for Orphan Disease Research, Children’s Hospital Boston and Dana Farber Cancer Institute
    Harvard Medical School
    Harvard Stem Cell Institute, Cambridge
    Stem Cell Program, Children’s Hospital Boston)

Abstract

Inhibition of DOT1L, the H3K79 histone methyltransferase, increases cell reprogramming and substituted for KLF4 and c-Myc, showing that chromatin-modifying enzymes act not only as facilitators but also as barriers to reprogramming.

Suggested Citation

  • Tamer T. Onder & Nergis Kara & Anne Cherry & Amit U. Sinha & Nan Zhu & Kathrin M. Bernt & Patrick Cahan & B. Ogan Mancarci & Juli Unternaehrer & Piyush B. Gupta & Eric S. Lander & Scott A. Armstrong &, 2012. "Chromatin-modifying enzymes as modulators of reprogramming," Nature, Nature, vol. 483(7391), pages 598-602, March.
    • Handle: RePEc:nat:nature:v:483:y:2012:i:7391:d:10.1038_nature10953
    DOI: 10.1038/nature10953
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    Citations

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    Cited by:

    1. Daniel F. Kaemena & Masahito Yoshihara & Meryam Beniazza & James Ashmore & Suling Zhao & Mårten Bertenstam & Victor Olariu & Shintaro Katayama & Keisuke Okita & Simon R. Tomlinson & Kosuke Yusa & Keis, 2023. "B1 SINE-binding ZFP266 impedes mouse iPSC generation through suppression of chromatin opening mediated by reprogramming factors," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    2. Allison P. Siegenfeld & Shelby A. Roseman & Heejin Roh & Nicholas Z. Lue & Corin C. Wagen & Eric Zhou & Sarah E. Johnstone & Martin J. Aryee & Brian B. Liau, 2022. "Polycomb-lamina antagonism partitions heterochromatin at the nuclear periphery," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    3. Bo Wang & Chen Li & Jin Ming & Linlin Wu & Shicai Fang & Yi Huang & Lihui Lin & He Liu & Junqi Kuang & Chengchen Zhao & Xingnan Huang & Huijian Feng & Jing Guo & Xuejie Yang & Liman Guo & Xiaofei Zhan, 2023. "The NuRD complex cooperates with SALL4 to orchestrate reprogramming," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    4. Ali Doğa Yücel & Vadim N. Gladyshev, 2024. "The long and winding road of reprogramming-induced rejuvenation," Nature Communications, Nature, vol. 15(1), pages 1-9, December.

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