Structure-guided engineering enables E3 ligase-free and versatile protein ubiquitination via UBE2E1
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DOI: 10.1038/s41467-024-45635-y
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- Byung-Hoon Lee & Ying Lu & Miguel A. Prado & Yuan Shi & Geng Tian & Shuangwu Sun & Suzanne Elsasser & Steven P. Gygi & Randall W. King & Daniel Finley, 2016. "USP14 deubiquitinates proteasome-bound substrates that are ubiquitinated at multiple sites," Nature, Nature, vol. 532(7599), pages 398-401, April.
- Daniel Horn-Ghetko & David T. Krist & J. Rajan Prabu & Kheewoong Baek & Monique P. C. Mulder & Maren Klügel & Daniel C. Scott & Huib Ovaa & Gary Kleiger & Brenda A. Schulman, 2021. "Ubiquitin ligation to F-box protein targets by SCF–RBR E3–E3 super-assembly," Nature, Nature, vol. 590(7847), pages 671-676, February.
- Man Pan & Qingyun Zheng & Tian Wang & Lujun Liang & Junxiong Mao & Chong Zuo & Ruichao Ding & Huasong Ai & Yuan Xie & Dong Si & Yuanyuan Yu & Lei Liu & Minglei Zhao, 2021. "Structural insights into Ubr1-mediated N-degron polyubiquitination," Nature, Nature, vol. 600(7888), pages 334-338, December.
- Chao Liu & Weixiao Liu & Yihong Ye & Wei Li, 2017. "Ufd2p synthesizes branched ubiquitin chains to promote the degradation of substrates modified with atypical chains," Nature Communications, Nature, vol. 8(1), pages 1-15, April.
- Indrajit Sahu & Sachitanand M. Mali & Prasad Sulkshane & Cong Xu & Andrey Rozenberg & Roni Morag & Manisha Priyadarsini Sahoo & Sumeet K. Singh & Zhanyu Ding & Yifan Wang & Sharleen Day & Yao Cong & O, 2021. "The 20S as a stand-alone proteasome in cells can degrade the ubiquitin tag," Nature Communications, Nature, vol. 12(1), pages 1-21, December.
- Kheewoong Baek & David T. Krist & J. Rajan Prabu & Spencer Hill & Maren Klügel & Lisa-Marie Neumaier & Susanne Gronau & Gary Kleiger & Brenda A. Schulman, 2020. "NEDD8 nucleates a multivalent cullin–RING–UBE2D ubiquitin ligation assembly," Nature, Nature, vol. 578(7795), pages 461-466, February.
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