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Proteomic analysis reveals key differences between squamous cell carcinomas and adenocarcinomas across multiple tissues

Author

Listed:
  • Qi Song

    (Fudan University)

  • Ye Yang

    (Fudan University)

  • Dongxian Jiang

    (Fudan University)

  • Zhaoyu Qin

    (Fudan University)

  • Chen Xu

    (Fudan University)

  • Haixing Wang

    (Fudan University)

  • Jie Huang

    (Fudan University)

  • Lingli Chen

    (Fudan University)

  • Rongkui Luo

    (Fudan University)

  • Xiaolei Zhang

    (Fudan University)

  • Yufeng Huang

    (Fudan University)

  • Lei Xu

    (Fudan University)

  • Zixiang Yu

    (Fudan University)

  • Subei Tan

    (Fudan University)

  • Minying Deng

    (Fudan University)

  • Ruqun Xue

    (Fudan University)

  • Jingbo Qie

    (Fudan University)

  • Kai Li

    (Fudan University)

  • Yanan Yin

    (Fudan University)

  • Xuetong Yue

    (Fudan University)

  • Xiaogang Sun

    (Henan Normal University)

  • Jieakesu Su

    (Fudan University)

  • Fuchu He

    (Beijing Institute of Lifeomics)

  • Chen Ding

    (Fudan University
    Henan Normal University
    Zhengzhou University)

  • Yingyong Hou

    (Fudan University)

Abstract

Squamous cell carcinoma (SCC) and adenocarcinoma (AC) are two main histological subtypes of solid cancer; however, SCCs are derived from different organs with similar morphologies, and it is challenging to distinguish the origin of metastatic SCCs. Here we report a deep proteomic analysis of 333 SCCs of 17 organs and 69 ACs of 7 organs. Proteomic comparison between SCCs and ACs identifies distinguishable pivotal pathways and molecules in those pathways play consistent adverse or opposite prognostic roles in ACs and SCCs. A comparison between common and rare SCCs highlights lipid metabolism may reinforce the malignancy of rare SCCs. Proteomic clusters reveal anatomical features, and kinase-transcription factor networks indicate differential SCC characteristics, while immune subtyping reveals diverse tumor microenvironments across and within diagnoses and identified potential druggable targets. Furthermore, tumor-specific proteins provide candidates with differentially diagnostic values. This proteomics architecture represents a public resource for researchers seeking a better understanding of SCCs and ACs.

Suggested Citation

  • Qi Song & Ye Yang & Dongxian Jiang & Zhaoyu Qin & Chen Xu & Haixing Wang & Jie Huang & Lingli Chen & Rongkui Luo & Xiaolei Zhang & Yufeng Huang & Lei Xu & Zixiang Yu & Subei Tan & Minying Deng & Ruqun, 2022. "Proteomic analysis reveals key differences between squamous cell carcinomas and adenocarcinomas across multiple tissues," Nature Communications, Nature, vol. 13(1), pages 1-20, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-31719-0
    DOI: 10.1038/s41467-022-31719-0
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