IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v15y2024i1d10.1038_s41467-024-45117-1.html
   My bibliography  Save this article

Bioinspired light-driven chloride pump with helical porphyrin channels

Author

Listed:
  • Chao Li

    (Beihang University
    Chinese Academy of Sciences)

  • Yi Zhai

    (Beihang University)

  • Heming Jiang

    (Shenzhen Bay Laboratory)

  • Siqi Li

    (Beihang University)

  • Pengxiang Liu

    (Beihang University)

  • Longcheng Gao

    (Beihang University)

  • Lei Jiang

    (Beihang University
    Chinese Academy of Sciences)

Abstract

Halorhodopsin, a light-driven chloride pump, utilizes photonic energy to drive chloride ions across biological membranes, regulating the ion balance and conveying biological information. In the light-driven chloride pump process, the chloride-binding chromophore (protonated Schiff base) is crucial, able to form the active center by absorbing light and triggering the transport cycle. Inspired by halorhodopsin, we demonstrate an artificial light-driven chloride pump using a helical porphyrin channel array with excellent photoactivity and specific chloride selectivity. The helical porphyrin channels are formed by a porphyrin-core star block copolymer, and the defects along the channels can be effectively repaired by doping a small number of porphyrins. The well-repaired porphyrin channel exhibits the light-driven Cl− migration against a 3-fold concentration gradient, showing the ion pumping behavior. The bio-inspired artificial light-driven chloride pump provides a prospect for designing bioinspired responsive ion channel systems and high-performance optogenetics.

Suggested Citation

  • Chao Li & Yi Zhai & Heming Jiang & Siqi Li & Pengxiang Liu & Longcheng Gao & Lei Jiang, 2024. "Bioinspired light-driven chloride pump with helical porphyrin channels," Nature Communications, Nature, vol. 15(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-45117-1
    DOI: 10.1038/s41467-024-45117-1
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-024-45117-1
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-024-45117-1?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Ranwen Ou & Huacheng Zhang & Vinh X. Truong & Lian Zhang & Hanaa M. Hegab & Li Han & Jue Hou & Xiwang Zhang & Ana Deletic & Lei Jiang & George P. Simon & Huanting Wang, 2020. "A sunlight-responsive metal–organic framework system for sustainable water desalination," Nature Sustainability, Nature, vol. 3(12), pages 1052-1058, December.
    2. Shihao Su & Yifan Zhang & Shengyuan Peng & Linxin Guo & Yong Liu & Engang Fu & Huijun Yao & Jinlong Du & Guanghua Du & Jianming Xue, 2022. "Multifunctional graphene heterogeneous nanochannel with voltage-tunable ion selectivity," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
    3. Ryan C. Rollings & Aaron T. Kuan & Jene A. Golovchenko, 2016. "Ion selectivity of graphene nanopores," Nature Communications, Nature, vol. 7(1), pages 1-7, September.
    4. Keiichi Inoue & Hikaru Ono & Rei Abe-Yoshizumi & Susumu Yoshizawa & Hiroyasu Ito & Kazuhiro Kogure & Hideki Kandori, 2013. "A light-driven sodium ion pump in marine bacteria," Nature Communications, Nature, vol. 4(1), pages 1-10, June.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Mai, Van-Phung & Yang, Ruey-Jen, 2020. "Boosting power generation from salinity gradient on high-density nanoporous membrane using thermal effect," Applied Energy, Elsevier, vol. 274(C).
    2. Lijuan Feng & Yihui Yuan & Bingjie Yan & Tiantian Feng & Yaping Jian & Jiacheng Zhang & Wenyan Sun & Ke Lin & Guangsheng Luo & Ning Wang, 2022. "Halogen hydrogen-bonded organic framework (XHOF) constructed by singlet open-shell diradical for efficient photoreduction of U(VI)," Nature Communications, Nature, vol. 13(1), pages 1-9, December.
    3. Rezakazemi, Mashallah & Arabi Shamsabadi, Ahmad & Lin, Haiqing & Luis, Patricia & Ramakrishna, Seeram & Aminabhavi, Tejraj M., 2021. "Sustainable MXenes-based membranes for highly energy-efficient separations," Renewable and Sustainable Energy Reviews, Elsevier, vol. 143(C).
    4. Di Wei & Feiyao Yang & Zhuoheng Jiang & Zhonglin Wang, 2022. "Flexible iontronics based on 2D nanofluidic material," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    5. Lei Zhang & Run-Han Li & Xiao-Xin Li & Shengyao Wang & Jiang Liu & Xiao-Xuan Hong & Long-Zhang Dong & Shun-Li Li & Ya-Qian Lan, 2024. "Photocatalytic aerobic oxidation of C(sp3)-H bonds," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    6. Jiao, Yanmei & Yang, Chun & Zhang, Wenyao & Wang, Qiuwang & Zhao, Cunlu, 2024. "A review on direct osmotic power generation: Mechanism and membranes," Renewable and Sustainable Energy Reviews, Elsevier, vol. 191(C).
    7. Weiwen Xin & Jingru Fu & Yongchao Qian & Lin Fu & Xiang-Yu Kong & Teng Ben & Lei Jiang & Liping Wen, 2022. "Biomimetic KcsA channels with ultra-selective K+ transport for monovalent ion sieving," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    8. Shihao Su & Yifan Zhang & Shengyuan Peng & Linxin Guo & Yong Liu & Engang Fu & Huijun Yao & Jinlong Du & Guanghua Du & Jianming Xue, 2022. "Multifunctional graphene heterogeneous nanochannel with voltage-tunable ion selectivity," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
    9. Shuqi Xu & Alice J. Hutchinson & Mahdiar Taheri & Ben Corry & Juan F. Torres, 2024. "Thermodiffusive desalination," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    10. Qing Guo & Zhuozhi Lai & Xiuhui Zuo & Weipeng Xian & Shaochun Wu & Liping Zheng & Zhifeng Dai & Sai Wang & Qi Sun, 2023. "Photoelectric responsive ionic channel for sustainable energy harvesting," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
    11. Xingya Li & Gengping Jiang & Meipeng Jian & Chen Zhao & Jue Hou & Aaron W. Thornton & Xinyi Zhang & Jefferson Zhe Liu & Benny D. Freeman & Huanting Wang & Lei Jiang & Huacheng Zhang, 2023. "Construction of angstrom-scale ion channels with versatile pore configurations and sizes by metal-organic frameworks," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    12. E. Podoliak & G. H. U. Lamm & E. Marin & A. V. Schellbach & D. A. Fedotov & A. Stetsenko & M. Asido & N. Maliar & G. Bourenkov & T. Balandin & C. Baeken & R. Astashkin & T. R. Schneider & A. Bateman &, 2024. "A subgroup of light-driven sodium pumps with an additional Schiff base counterion," Nature Communications, Nature, vol. 15(1), pages 1-16, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-45117-1. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.