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Bioinspired light-driven chloride pump with helical porphyrin channels

Author

Listed:
  • Chao Li

    (Beihang University
    Chinese Academy of Sciences)

  • Yi Zhai

    (Beihang University)

  • Heming Jiang

    (Shenzhen Bay Laboratory)

  • Siqi Li

    (Beihang University)

  • Pengxiang Liu

    (Beihang University)

  • Longcheng Gao

    (Beihang University)

  • Lei Jiang

    (Beihang University
    Chinese Academy of Sciences)

Abstract

Halorhodopsin, a light-driven chloride pump, utilizes photonic energy to drive chloride ions across biological membranes, regulating the ion balance and conveying biological information. In the light-driven chloride pump process, the chloride-binding chromophore (protonated Schiff base) is crucial, able to form the active center by absorbing light and triggering the transport cycle. Inspired by halorhodopsin, we demonstrate an artificial light-driven chloride pump using a helical porphyrin channel array with excellent photoactivity and specific chloride selectivity. The helical porphyrin channels are formed by a porphyrin-core star block copolymer, and the defects along the channels can be effectively repaired by doping a small number of porphyrins. The well-repaired porphyrin channel exhibits the light-driven Cl− migration against a 3-fold concentration gradient, showing the ion pumping behavior. The bio-inspired artificial light-driven chloride pump provides a prospect for designing bioinspired responsive ion channel systems and high-performance optogenetics.

Suggested Citation

  • Chao Li & Yi Zhai & Heming Jiang & Siqi Li & Pengxiang Liu & Longcheng Gao & Lei Jiang, 2024. "Bioinspired light-driven chloride pump with helical porphyrin channels," Nature Communications, Nature, vol. 15(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-45117-1
    DOI: 10.1038/s41467-024-45117-1
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