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A genome-wide association study yields five novel thyroid cancer risk loci

Author

Listed:
  • Julius Gudmundsson

    (deCODE genetics/AMGEN)

  • Gudmar Thorleifsson

    (deCODE genetics/AMGEN)

  • Jon K. Sigurdsson

    (deCODE genetics/AMGEN)

  • Lilja Stefansdottir

    (deCODE genetics/AMGEN)

  • Jon G. Jonasson

    (Landspitali-University Hospital
    Faculty of Medicine, University of Iceland
    The Icelandic Cancer Registry)

  • Sigurjon A. Gudjonsson

    (deCODE genetics/AMGEN)

  • Daniel F. Gudbjartsson

    (deCODE genetics/AMGEN)

  • Gisli Masson

    (deCODE genetics/AMGEN)

  • Hrefna Johannsdottir

    (deCODE genetics/AMGEN)

  • Gisli H. Halldorsson

    (deCODE genetics/AMGEN)

  • Simon N. Stacey

    (deCODE genetics/AMGEN)

  • Hannes Helgason

    (deCODE genetics/AMGEN
    School of Engineering and Natural Sciences, University of Iceland)

  • Patrick Sulem

    (deCODE genetics/AMGEN)

  • Leigha Senter

    (Ohio State University Comprehensive Cancer Center)

  • Huiling He

    (Ohio State University Comprehensive Cancer Center)

  • Sandya Liyanarachchi

    (Ohio State University Comprehensive Cancer Center)

  • Matthew D. Ringel

    (Diabetes, and Metabolism, The Ohio State University)

  • Esperanza Aguillo

    (University Hospital)

  • Angeles Panadero

    (Ciudad de Coria Hospital)

  • Enrique Prats

    (University Hospital)

  • Almudena Garcia-Castaño

    (Marques de Valdecilla University Hospital)

  • Ana De Juan

    (Marques de Valdecilla University Hospital)

  • Fernando Rivera

    (Marques de Valdecilla University Hospital)

  • Li Xu

    (The University of Texas MD Anderson Cancer Center)

  • Lambertus A. Kiemeney

    (Radboud University Medical Centre, Radboud Institute for Health Sciences)

  • Gudmundur I. Eyjolfsson

    (The Laboratory in Mjodd)

  • Olof Sigurdardottir

    (Akureyri Hospital)

  • Isleifur Olafsson

    (Landspitali-University Hospital)

  • Hoskuldur Kristvinsson

    (Landspitali-University Hospital)

  • Romana T. Netea-Maier

    (Radboud University Medical Centre, Radboud Institute for Health Sciences)

  • Thorvaldur Jonsson

    (Landspitali-University Hospital
    Faculty of Medicine, University of Iceland)

  • Jose I. Mayordomo

    (University of Colorado Hospital)

  • Theo S. Plantinga

    (Radboud University Medical Center, Radboud Institute for Molecular Life Sciences)

  • Hannes Hjartarson

    (Landspitali-University Hospital)

  • Jon Hrafnkelsson

    (Landspitali-University Hospital)

  • Erich M. Sturgis

    (The University of Texas MD Anderson Cancer Center)

  • Unnur Thorsteinsdottir

    (deCODE genetics/AMGEN
    Faculty of Medicine, University of Iceland)

  • Thorunn Rafnar

    (deCODE genetics/AMGEN)

  • Albert de la Chapelle

    (Ohio State University Comprehensive Cancer Center)

  • Kari Stefansson

    (deCODE genetics/AMGEN
    Faculty of Medicine, University of Iceland)

Abstract

The great majority of thyroid cancers are of the non-medullary type. Here we report findings from a genome-wide association study of non-medullary thyroid cancer, including in total 3,001 patients and 287,550 controls from five study groups of European descent. Our results yield five novel loci (all with Pcombined

Suggested Citation

  • Julius Gudmundsson & Gudmar Thorleifsson & Jon K. Sigurdsson & Lilja Stefansdottir & Jon G. Jonasson & Sigurjon A. Gudjonsson & Daniel F. Gudbjartsson & Gisli Masson & Hrefna Johannsdottir & Gisli H. , 2017. "A genome-wide association study yields five novel thyroid cancer risk loci," Nature Communications, Nature, vol. 8(1), pages 1-8, April.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms14517
    DOI: 10.1038/ncomms14517
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    Cited by:

    1. Rosalie B. T. M. Sterenborg & Inga Steinbrenner & Yong Li & Melissa N. Bujnis & Tatsuhiko Naito & Eirini Marouli & Tessel E. Galesloot & Oladapo Babajide & Laura Andreasen & Arne Astrup & Bjørn Olav Å, 2024. "Multi-trait analysis characterizes the genetics of thyroid function and identifies causal associations with clinical implications," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    2. Rishi Kumar Jaiswal & Kai-Hang Lei & Megan Chastain & Yuan Wang & Olga Shiva & Shan Li & Zhongsheng You & Peter Chi & Weihang Chai, 2023. "CaMKK2 and CHK1 phosphorylate human STN1 in response to replication stress to protect stalled forks from aberrant resection," Nature Communications, Nature, vol. 14(1), pages 1-18, December.

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