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Determinants of epidemic size and the impacts of lulls in seasonal influenza virus circulation

Author

Listed:
  • Simon P. J. Jong

    (University of Amsterdam)

  • Zandra C. Felix Garza

    (University of Amsterdam)

  • Joseph C. Gibson

    (University of Amsterdam)

  • Sarah Leeuwen

    (University of Amsterdam)

  • Robert P. Vries

    (Utrecht University)

  • Geert-Jan Boons

    (Utrecht University
    University of Georgia
    Utrecht University
    University of Georgia)

  • Marliek Hoesel

    (University of Amsterdam)

  • Karen Haan

    (University of Amsterdam)

  • Laura E. Groeningen

    (University of Amsterdam)

  • Katina D. Hulme

    (University of Amsterdam)

  • Hugo D. G. Willigen

    (University of Amsterdam)

  • Elke Wynberg

    (University of Amsterdam
    Public Health Service of Amsterdam)

  • Godelieve J. Bree

    (University of Amsterdam)

  • Amy Matser

    (Public Health Service of Amsterdam)

  • Margreet Bakker

    (University of Amsterdam)

  • Lia Hoek

    (University of Amsterdam)

  • Maria Prins

    (Public Health Service of Amsterdam
    University of Amsterdam)

  • Neeltje A. Kootstra

    (University of Amsterdam)

  • Dirk Eggink

    (University of Amsterdam
    National Institute for Public Health and the Environment)

  • Brooke E. Nichols

    (University of Amsterdam
    Boston University)

  • Alvin X. Han

    (University of Amsterdam)

  • Menno D. Jong

    (University of Amsterdam)

  • Colin A. Russell

    (University of Amsterdam
    Boston University)

Abstract

During the COVID-19 pandemic, levels of seasonal influenza virus circulation were unprecedentedly low, leading to concerns that a lack of exposure to influenza viruses, combined with waning antibody titres, could result in larger and/or more severe post-pandemic seasonal influenza epidemics. However, in most countries the first post-pandemic influenza season was not unusually large and/or severe. Here, based on an analysis of historical influenza virus epidemic patterns from 2002 to 2019, we show that historic lulls in influenza virus circulation had relatively minor impacts on subsequent epidemic size and that epidemic size was more substantially impacted by season-specific effects unrelated to the magnitude of circulation in prior seasons. From measurements of antibody levels from serum samples collected each year from 2017 to 2021, we show that the rate of waning of antibody titres against influenza virus during the pandemic was smaller than assumed in predictive models. Taken together, these results partially explain why the re-emergence of seasonal influenza virus epidemics was less dramatic than anticipated and suggest that influenza virus epidemic dynamics are not currently amenable to multi-season prediction.

Suggested Citation

  • Simon P. J. Jong & Zandra C. Felix Garza & Joseph C. Gibson & Sarah Leeuwen & Robert P. Vries & Geert-Jan Boons & Marliek Hoesel & Karen Haan & Laura E. Groeningen & Katina D. Hulme & Hugo D. G. Willi, 2024. "Determinants of epidemic size and the impacts of lulls in seasonal influenza virus circulation," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
  • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-023-44668-z
    DOI: 10.1038/s41467-023-44668-z
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    References listed on IDEAS

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    1. Frederik Broszeit & Rosanne J. Beek & Luca Unione & Theo M. Bestebroer & Digantkumar Chapla & Jeong-Yeh Yang & Kelley W. Moremen & Sander Herfst & Ron A. M. Fouchier & Robert P. Vries & Geert-Jan Boon, 2021. "Glycan remodeled erythrocytes facilitate antigenic characterization of recent A/H3N2 influenza viruses," Nature Communications, Nature, vol. 12(1), pages 1-12, December.
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