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Middle-aged individuals may be in a perpetual state of H3N2 influenza virus susceptibility

Author

Listed:
  • Sigrid Gouma

    (University of Pennsylvania)

  • Kangchon Kim

    (University of Chicago)

  • Madison E. Weirick

    (University of Pennsylvania)

  • Megan E. Gumina

    (University of Pennsylvania)

  • Angela Branche

    (University of Rochester Medical Center)

  • David J. Topham

    (University of Rochester Medical Center)

  • Emily T. Martin

    (University of Michigan School of Public Health)

  • Arnold S. Monto

    (University of Michigan School of Public Health)

  • Sarah Cobey

    (University of Chicago)

  • Scott E. Hensley

    (University of Pennsylvania)

Abstract

Influenza virus exposures in childhood can establish long-lived memory B cell responses that can be recalled later in life. Here, we complete a large serological survey to elucidate the specificity of antibodies against contemporary H3N2 viruses in differently aged individuals who were likely primed with different H3N2 strains in childhood. We find that most humans who were first infected in childhood with H3N2 viral strains from the 1960s and 1970s possess non-neutralizing antibodies against contemporary 3c2.A H3N2 viruses. We find that 3c2.A H3N2 virus infections boost non-neutralizing H3N2 antibodies in middle-aged individuals, potentially leaving many of them in a perpetual state of 3c2.A H3N2 viral susceptibility.

Suggested Citation

  • Sigrid Gouma & Kangchon Kim & Madison E. Weirick & Megan E. Gumina & Angela Branche & David J. Topham & Emily T. Martin & Arnold S. Monto & Sarah Cobey & Scott E. Hensley, 2020. "Middle-aged individuals may be in a perpetual state of H3N2 influenza virus susceptibility," Nature Communications, Nature, vol. 11(1), pages 1-8, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-18465-x
    DOI: 10.1038/s41467-020-18465-x
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    Cited by:

    1. Tim K. Tsang & Ranawaka A. P. M. Perera & Vicky J. Fang & Jessica Y. Wong & Eunice Y. Shiu & Hau Chi So & Dennis K. M. Ip & J. S. Malik Peiris & Gabriel M. Leung & Benjamin J. Cowling & Simon Caucheme, 2022. "Reconstructing antibody dynamics to estimate the risk of influenza virus infection," Nature Communications, Nature, vol. 13(1), pages 1-8, December.
    2. Vijaykrishna Dhanasekaran & Sheena Sullivan & Kimberly M. Edwards & Ruopeng Xie & Arseniy Khvorov & Sophie A. Valkenburg & Benjamin J. Cowling & Ian G. Barr, 2022. "Human seasonal influenza under COVID-19 and the potential consequences of influenza lineage elimination," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    3. Simon P. J. Jong & Zandra C. Felix Garza & Joseph C. Gibson & Sarah Leeuwen & Robert P. Vries & Geert-Jan Boons & Marliek Hoesel & Karen Haan & Laura E. Groeningen & Katina D. Hulme & Hugo D. G. Willi, 2024. "Determinants of epidemic size and the impacts of lulls in seasonal influenza virus circulation," Nature Communications, Nature, vol. 15(1), pages 1-11, December.

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