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Effective weight control via an implanted self-powered vagus nerve stimulation device

Author

Listed:
  • Guang Yao

    (University of Wisconsin-Madison
    University of Electronic Science and Technology of China)

  • Lei Kang

    (University of Wisconsin-Madison
    Peking University First Hospital)

  • Jun Li

    (University of Wisconsin-Madison)

  • Yin Long

    (University of Wisconsin-Madison
    University of Electronic Science and Technology of China)

  • Hao Wei

    (University of Wisconsin-Madison)

  • Carolina A. Ferreira

    (University of Wisconsin-Madison)

  • Justin J. Jeffery

    (University of Wisconsin Carbone Cancer Center)

  • Yuan Lin

    (University of Electronic Science and Technology of China)

  • Weibo Cai

    (University of Wisconsin-Madison)

  • Xudong Wang

    (University of Wisconsin-Madison)

Abstract

In vivo vagus nerve stimulation holds great promise in regulating food intake for obesity treatment. Here we present an implanted vagus nerve stimulation system that is battery-free and spontaneously responsive to stomach movement. The vagus nerve stimulation system comprises a flexible and biocompatible nanogenerator that is attached on the surface of stomach. It generates biphasic electric pulses in responsive to the peristalsis of stomach. The electric signals generated by this device can stimulate the vagal afferent fibers to reduce food intake and achieve weight control. This strategy is successfully demonstrated on rat models. Within 100 days, the average body weight is controlled at 350 g, 38% less than the control groups. This work correlates nerve stimulation with targeted organ functionality through a smart, self-responsive system, and demonstrated highly effective weight control. This work also provides a concept in therapeutic technology using artificial nerve signal generated from coordinated body activities.

Suggested Citation

  • Guang Yao & Lei Kang & Jun Li & Yin Long & Hao Wei & Carolina A. Ferreira & Justin J. Jeffery & Yuan Lin & Weibo Cai & Xudong Wang, 2018. "Effective weight control via an implanted self-powered vagus nerve stimulation device," Nature Communications, Nature, vol. 9(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-07764-z
    DOI: 10.1038/s41467-018-07764-z
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    Cited by:

    1. Zhuo Liu & Yiran Hu & Xuecheng Qu & Ying Liu & Sijing Cheng & Zhengmin Zhang & Yizhu Shan & Ruizeng Luo & Sixian Weng & Hui Li & Hongxia Niu & Min Gu & Yan Yao & Bojing Shi & Ningning Wang & Wei Hua &, 2024. "A self-powered intracardiac pacemaker in swine model," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    2. Zhouquan Sun & Yuefan Jin & Jiabei Luo & Linpeng Li & Yue Ding & Yu Luo & Yan Qi & Yaogang Li & Qinghong Zhang & Kerui Li & Haibo Shi & Shankai Yin & Hongzhi Wang & Hui Wang & Chengyi Hou, 2024. "A bioabsorbable mechanoelectric fiber as electrical stimulation suture," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    3. Fei Jin & Tong Li & Zhidong Wei & Ruiying Xiong & Lili Qian & Juan Ma & Tao Yuan & Qi Wu & Chengteng Lai & Xiying Ma & Fuyi Wang & Ying Zhao & Fengyu Sun & Ting Wang & Zhang-Qi Feng, 2022. "Biofeedback electrostimulation for bionic and long-lasting neural modulation," Nature Communications, Nature, vol. 13(1), pages 1-12, December.

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