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A light-activatable theranostic combination for ratiometric hypoxia imaging and oxygen-deprived drug activity enhancement

Author

Listed:
  • Lei Ge

    (Nanjing University)

  • Yikai Tang

    (Nanjing University)

  • Chongzhi Wang

    (Nanjing University)

  • Jian Chen

    (Nanjing University)

  • Hui Mao

    (Emory University)

  • Xiqun Jiang

    (Nanjing University)

Abstract

While performing oxygen-related tumour treatments such as chemotherapy and photodynamic therapy, real-time monitoring hypoxia of tumour is of great value and significance. Here, we design a theranostic combination for light-activated ratiometric hypoxia imaging, hypoxia modulating and prodrug activation. This combination consisted of an oxygen-sensitive near-infrared-emitting ratiometric phosphorescence probe and a hypoxia-activated prodrug-loaded covalent organic framework. In this combination, the probe plays two roles, including quantitative monitoring of oxygen concentration by ratiometric imaging and consuming the oxygen of tumour under light excitation by photodynamic therapy. Meanwhile, the enhanced hypoxia microenvironment of tumour can raise the cytotoxicity of prodrug loaded in covalent organic framework, resulting in boosting antitumour therapeutic effects in vivo. This theranostic combination can precisely provide therapeutic regime and screen hypoxia-activated prodrugs based on real-time tumour hypoxia level, offering a strategy to develop hypoxia mediated tumour theranostics with hypoxia targeted prodrugs.

Suggested Citation

  • Lei Ge & Yikai Tang & Chongzhi Wang & Jian Chen & Hui Mao & Xiqun Jiang, 2024. "A light-activatable theranostic combination for ratiometric hypoxia imaging and oxygen-deprived drug activity enhancement," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-023-44429-y
    DOI: 10.1038/s41467-023-44429-y
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    References listed on IDEAS

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    1. Xianchuang Zheng & Xin Wang & Hui Mao & Wei Wu & Baorui Liu & Xiqun Jiang, 2015. "Hypoxia-specific ultrasensitive detection of tumours and cancer cells in vivo," Nature Communications, Nature, vol. 6(1), pages 1-12, May.
    2. Xiangdong Xue & Yee Huang & Ruonan Bo & Bei Jia & Hao Wu & Ye Yuan & Zhongling Wang & Zhao Ma & Di Jing & Xiaobao Xu & Weimin Yu & Tzu-yin Lin & Yuanpei Li, 2018. "Trojan Horse nanotheranostics with dual transformability and multifunctionality for highly effective cancer treatment," Nature Communications, Nature, vol. 9(1), pages 1-15, December.
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