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Trojan Horse nanotheranostics with dual transformability and multifunctionality for highly effective cancer treatment

Author

Listed:
  • Xiangdong Xue

    (University of California Davis)

  • Yee Huang

    (University of California Davis
    Institute of Animal Husbandry and Veterinary Science, Zhejiang Academy of Agricultural Sciences)

  • Ruonan Bo

    (University of California Davis)

  • Bei Jia

    (University of California Davis)

  • Hao Wu

    (University of California Davis)

  • Ye Yuan

    (University of California Davis)

  • Zhongling Wang

    (University of California Davis
    Shanghai Jiao Tong University School of Medicine)

  • Zhao Ma

    (University of California Davis)

  • Di Jing

    (University of California Davis
    Central South University)

  • Xiaobao Xu

    (University of California Davis)

  • Weimin Yu

    (University of California Davis
    Renmin Hospital of Wuhan University)

  • Tzu-yin Lin

    (University of California Davis)

  • Yuanpei Li

    (University of California Davis)

Abstract

Nanotheranostics with integrated diagnostic and therapeutic functions show exciting potentials towards precision nanomedicine. However, targeted delivery of nanotheranostics is hindered by several biological barriers. Here, we report the development of a dual size/charge- transformable, Trojan-Horse nanoparticle (pPhD NP) for delivery of ultra-small, full active pharmaceutical ingredients (API) nanotheranostics with integrated dual-modal imaging and trimodal therapeutic functions. pPhD NPs exhibit ideal size and charge for drug transportation. In tumour microenvironment, pPhD NPs responsively transform to full API nanotheranostics with ultra-small size and higher surface charge, which dramatically facilitate the tumour penetration and cell internalisation. pPhD NPs enable visualisation of biodistribution by near-infrared fluorescence imaging, tumour accumulation and therapeutic effect by magnetic resonance imaging. Moreover, the synergistic photothermal-, photodynamic- and chemo-therapies achieve a 100% complete cure rate on both subcutaneous and orthotopic oral cancer models. This nanoplatform with powerful delivery efficiency and versatile theranostic functions shows enormous potentials to improve cancer treatment.

Suggested Citation

  • Xiangdong Xue & Yee Huang & Ruonan Bo & Bei Jia & Hao Wu & Ye Yuan & Zhongling Wang & Zhao Ma & Di Jing & Xiaobao Xu & Weimin Yu & Tzu-yin Lin & Yuanpei Li, 2018. "Trojan Horse nanotheranostics with dual transformability and multifunctionality for highly effective cancer treatment," Nature Communications, Nature, vol. 9(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-06093-5
    DOI: 10.1038/s41467-018-06093-5
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    Cited by:

    1. Lei Ge & Yikai Tang & Chongzhi Wang & Jian Chen & Hui Mao & Xiqun Jiang, 2024. "A light-activatable theranostic combination for ratiometric hypoxia imaging and oxygen-deprived drug activity enhancement," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    2. Xiaoqian Ma & Nuo Lin & Qing Yang & Peifei Liu & Haizhen Ding & Mengjiao Xu & Fangfang Ren & Zhiyang Shen & Ke Hu & Shanshan Meng & Hongmin Chen, 2024. "Biodegradable copper-iodide clusters modulate mitochondrial function and suppress tumor growth under ultralow-dose X-ray irradiation," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    3. Xin Li & Yong Hu & Xingcai Zhang & Xiangyang Shi & Wolfgang J. Parak & Andrij Pich, 2024. "Transvascular transport of nanocarriers for tumor delivery," Nature Communications, Nature, vol. 15(1), pages 1-12, December.

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