IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v6y2015i1d10.1038_ncomms6834.html
   My bibliography  Save this article

Hypoxia-specific ultrasensitive detection of tumours and cancer cells in vivo

Author

Listed:
  • Xianchuang Zheng

    (Key Laboratory of High Performance Polymer Materials and Technology (Nanjing University), Ministry of Education, College of Chemistry & Chemical Engineering, Nanjing University)

  • Xin Wang

    (Key Laboratory of High Performance Polymer Materials and Technology (Nanjing University), Ministry of Education, College of Chemistry & Chemical Engineering, Nanjing University)

  • Hui Mao

    (Emory University)

  • Wei Wu

    (Key Laboratory of High Performance Polymer Materials and Technology (Nanjing University), Ministry of Education, College of Chemistry & Chemical Engineering, Nanjing University)

  • Baorui Liu

    (Affiliated Drum Tower Hospital, Medical School of Nanjing University)

  • Xiqun Jiang

    (Key Laboratory of High Performance Polymer Materials and Technology (Nanjing University), Ministry of Education, College of Chemistry & Chemical Engineering, Nanjing University)

Abstract

Highly sensitive and specific non-invasive molecular imaging methods are particularly desirable for the early detection of cancers. Here we report a near-infrared optical imaging probe highly specific to the hypoxic tumour microenvironment to detect tumour and cancer cells with the sensitivity to a few thousands cancer cells. This oxygen-sensitive, near-infrared emitting and water-soluble phosphorescent macromolecular probe can not only report the hypoxic tumour environment of various cancer models, including metastatic tumours in vivo, but can also detect a small amount of cancer cells before the formation of the tumour based on the increased oxygen consumption during cancer cell proliferation. Thus, the reported hypoxia-sensitive probe may offer an imaging tool for characterizing the tumour microenvironment in vivo, detecting cancer cells at a very early stage of tumour development and lymph node metastasis.

Suggested Citation

  • Xianchuang Zheng & Xin Wang & Hui Mao & Wei Wu & Baorui Liu & Xiqun Jiang, 2015. "Hypoxia-specific ultrasensitive detection of tumours and cancer cells in vivo," Nature Communications, Nature, vol. 6(1), pages 1-12, May.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms6834
    DOI: 10.1038/ncomms6834
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/ncomms6834
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/ncomms6834?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Lei Ge & Yikai Tang & Chongzhi Wang & Jian Chen & Hui Mao & Xiqun Jiang, 2024. "A light-activatable theranostic combination for ratiometric hypoxia imaging and oxygen-deprived drug activity enhancement," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    2. Xing Wang Liu & Weijun Zhao & Yue Wu & Zhengong Meng & Zikai He & Xin Qi & Yiran Ren & Zhen-Qiang Yu & Ben Zhong Tang, 2022. "Photo-thermo-induced room-temperature phosphorescence through solid-state molecular motion," Nature Communications, Nature, vol. 13(1), pages 1-8, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms6834. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.