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Hypoxia-specific ultrasensitive detection of tumours and cancer cells in vivo

Author

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  • Xianchuang Zheng

    (Key Laboratory of High Performance Polymer Materials and Technology (Nanjing University), Ministry of Education, College of Chemistry & Chemical Engineering, Nanjing University)

  • Xin Wang

    (Key Laboratory of High Performance Polymer Materials and Technology (Nanjing University), Ministry of Education, College of Chemistry & Chemical Engineering, Nanjing University)

  • Hui Mao

    (Emory University)

  • Wei Wu

    (Key Laboratory of High Performance Polymer Materials and Technology (Nanjing University), Ministry of Education, College of Chemistry & Chemical Engineering, Nanjing University)

  • Baorui Liu

    (Affiliated Drum Tower Hospital, Medical School of Nanjing University)

  • Xiqun Jiang

    (Key Laboratory of High Performance Polymer Materials and Technology (Nanjing University), Ministry of Education, College of Chemistry & Chemical Engineering, Nanjing University)

Abstract

Highly sensitive and specific non-invasive molecular imaging methods are particularly desirable for the early detection of cancers. Here we report a near-infrared optical imaging probe highly specific to the hypoxic tumour microenvironment to detect tumour and cancer cells with the sensitivity to a few thousands cancer cells. This oxygen-sensitive, near-infrared emitting and water-soluble phosphorescent macromolecular probe can not only report the hypoxic tumour environment of various cancer models, including metastatic tumours in vivo, but can also detect a small amount of cancer cells before the formation of the tumour based on the increased oxygen consumption during cancer cell proliferation. Thus, the reported hypoxia-sensitive probe may offer an imaging tool for characterizing the tumour microenvironment in vivo, detecting cancer cells at a very early stage of tumour development and lymph node metastasis.

Suggested Citation

  • Xianchuang Zheng & Xin Wang & Hui Mao & Wei Wu & Baorui Liu & Xiqun Jiang, 2015. "Hypoxia-specific ultrasensitive detection of tumours and cancer cells in vivo," Nature Communications, Nature, vol. 6(1), pages 1-12, May.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms6834
    DOI: 10.1038/ncomms6834
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    Cited by:

    1. Wensheng Xu & Bowei Wang & Shuai Liu & Wangwang Fang & Qinglong Jia & Jiayi Liu & Changchang Bo & Xilong Yan & Yang Li & Ligong Chen, 2024. "Urea-formaldehyde resin room temperature phosphorescent material with ultra-long afterglow and adjustable phosphorescence performance," Nature Communications, Nature, vol. 15(1), pages 1-10, December.
    2. Lei Ge & Yikai Tang & Chongzhi Wang & Jian Chen & Hui Mao & Xiqun Jiang, 2024. "A light-activatable theranostic combination for ratiometric hypoxia imaging and oxygen-deprived drug activity enhancement," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    3. Xing Wang Liu & Weijun Zhao & Yue Wu & Zhengong Meng & Zikai He & Xin Qi & Yiran Ren & Zhen-Qiang Yu & Ben Zhong Tang, 2022. "Photo-thermo-induced room-temperature phosphorescence through solid-state molecular motion," Nature Communications, Nature, vol. 13(1), pages 1-8, December.

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