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LncRNA MIR200CHG inhibits EMT in gastric cancer by stabilizing miR-200c from target-directed miRNA degradation

Author

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  • Yixiao Zhu

    (Sun Yat-sen University Cancer Center
    The Chinese University of Hong Kong
    Central South University)

  • Chengmei Huang

    (Sun Yat-sen University Cancer Center)

  • Chao Zhang

    (Sun Yat-sen University Cancer Center)

  • Yi Zhou

    (Sun Yat-sen University Cancer Center)

  • Enen Zhao

    (Sun Yat-sen University Cancer Center)

  • Yaxin Zhang

    (Sun Yat-sen University Cancer Center)

  • Xingyan Pan

    (Sun Yat-sen University Cancer Center)

  • Huilin Huang

    (Sun Yat-sen University Cancer Center)

  • Wenting Liao

    (Sun Yat-sen University Cancer Center)

  • Xin Wang

    (The Chinese University of Hong Kong
    The Chinese University of Hong Kong
    The Chinese University of Hong Kong, Shenzhen)

Abstract

Gastric cancer (GC) is a heterogeneous disease, threatening millions of lives worldwide, yet the functional roles of long non-coding RNAs (lncRNAs) in different GC subtypes remain poorly characterized. Microsatellite stable (MSS)/epithelial-mesenchymal transition (EMT) GC is the most aggressive subtype associated with a poor prognosis. Here, we apply integrated network analysis to uncover lncRNA heterogeneity between GC subtypes, and identify MIR200CHG as a master regulator mediating EMT specifically in MSS/EMT GC. The expression of MIR200CHG is silenced in MSS/EMT GC by promoter hypermethylation, associated with poor prognosis. MIR200CHG reverses the mesenchymal identity of GC cells in vitro and inhibits metastasis in vivo. Mechanistically, MIR200CHG not only facilitates the biogenesis of its intronic miRNAs miR-200c and miR-141, but also protects miR-200c from target-directed miRNA degradation (TDMD) through direct binding to miR-200c. Our studies reveal a landscape of a subtype-specific lncRNA regulatory network, providing clinically relevant biological insights towards MSS/EMT GC.

Suggested Citation

  • Yixiao Zhu & Chengmei Huang & Chao Zhang & Yi Zhou & Enen Zhao & Yaxin Zhang & Xingyan Pan & Huilin Huang & Wenting Liao & Xin Wang, 2023. "LncRNA MIR200CHG inhibits EMT in gastric cancer by stabilizing miR-200c from target-directed miRNA degradation," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-43974-w
    DOI: 10.1038/s41467-023-43974-w
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