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lncRNAs transactivate STAU1-mediated mRNA decay by duplexing with 3′ UTRs via Alu elements

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  • Chenguang Gong

    (School of Medicine and Dentistry, University of Rochester
    Center for RNA Biology, University of Rochester)

  • Lynne E. Maquat

    (School of Medicine and Dentistry, University of Rochester
    Center for RNA Biology, University of Rochester)

Abstract

Role for long non-coding RNAs The RNA-binding protein Staufen1 (STAU1) promotes the degradation of double-stranded messenger RNA in the process known as Staufen-mediated decay (SMD). STAU1 binds to transcripts in the 3′ untranslated region (UTR), and although a specific stem-loop binding site had been defined for one SMD target, it was unclear how STAU1 was directed to other SMD targets that lack this structure. Chenguang Gong and Lynne Maquat report that pairing of Alu element sequences in long non-coding RNAs (lncRNAs) and in the 3′ UTR of the SMD target generates a double-stranded RNA structure that STAU1 recognizes. This result highlights a new function for lncRNAs.

Suggested Citation

  • Chenguang Gong & Lynne E. Maquat, 2011. "lncRNAs transactivate STAU1-mediated mRNA decay by duplexing with 3′ UTRs via Alu elements," Nature, Nature, vol. 470(7333), pages 284-288, February.
    • Handle: RePEc:nat:nature:v:470:y:2011:i:7333:d:10.1038_nature09701
    DOI: 10.1038/nature09701
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    Cited by:

    1. Yixiao Zhu & Chengmei Huang & Chao Zhang & Yi Zhou & Enen Zhao & Yaxin Zhang & Xingyan Pan & Huilin Huang & Wenting Liao & Xin Wang, 2023. "LncRNA MIR200CHG inhibits EMT in gastric cancer by stabilizing miR-200c from target-directed miRNA degradation," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
    2. Huaijun Wang & Tiantian Ye & Zilong Guo & Yilong Yao & Haifu Tu & Pengfei Wang & Yu Zhang & Yao Wang & Xiaokai Li & Bingchen Li & Haiyan Xiong & Xuelei Lai & Lizhong Xiong, 2024. "A double-stranded RNA binding protein enhances drought resistance via protein phase separation in rice," Nature Communications, Nature, vol. 15(1), pages 1-14, December.

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