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Long non-coding antisense RNA controls Uchl1 translation through an embedded SINEB2 repeat

Author

Listed:
  • Claudia Carrieri

    (Area of Neuroscience, International School for Advanced Studies (SISSA), via Bonomea 265, 34136 Trieste, Italy)

  • Laura Cimatti

    (Area of Neuroscience, International School for Advanced Studies (SISSA), via Bonomea 265, 34136 Trieste, Italy)

  • Marta Biagioli

    (Area of Neuroscience, International School for Advanced Studies (SISSA), via Bonomea 265, 34136 Trieste, Italy
    The Giovanni Armenise-Harvard Foundation Laboratory, via Bonomea 265, 34136 Trieste, Italy)

  • Anne Beugnet

    (Laboratory of Molecular Histology and Cell Growth, DIBIT, San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milan, Italy)

  • Silvia Zucchelli

    (Area of Neuroscience, International School for Advanced Studies (SISSA), via Bonomea 265, 34136 Trieste, Italy
    The Giovanni Armenise-Harvard Foundation Laboratory, via Bonomea 265, 34136 Trieste, Italy)

  • Stefania Fedele

    (Area of Neuroscience, International School for Advanced Studies (SISSA), via Bonomea 265, 34136 Trieste, Italy)

  • Elisa Pesce

    (Laboratory of Molecular Histology and Cell Growth, DIBIT, San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milan, Italy)

  • Isidre Ferrer

    (Institute of Neuropathology, IDIBELL-University Hospital of Bellvitge, Carrer Feixa Llarga sn, 08907 Hospitalet de Llobregat)

  • Licio Collavin

    (Laboratorio Nazionale Consorzio Interuniversitario Biotecnologie (LNCIB), Area Science Park, Padriciano 99, 34149 Trieste, Italy
    University of Trieste, via Giorgeri 1, 34129 Trieste, Italy)

  • Claudio Santoro

    (University of Eastern Piedmont, Viale Solaroli 17, 28100 Novara, Italy)

  • Alistair R. R. Forrest

    (Omics Science Center, RIKEN Yokohama Institute, 1-7-22 Suehiro-chô, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan)

  • Piero Carninci

    (Omics Science Center, RIKEN Yokohama Institute, 1-7-22 Suehiro-chô, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan)

  • Stefano Biffo

    (Laboratory of Molecular Histology and Cell Growth, DIBIT, San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milan, Italy
    University of Eastern Piedmont, Viale T. Michel 11, 15121 Alessandria, Italy)

  • Elia Stupka

    (Center for Translational Genomics and Bioinformatics, San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milan, Italy)

  • Stefano Gustincich

    (Area of Neuroscience, International School for Advanced Studies (SISSA), via Bonomea 265, 34136 Trieste, Italy
    The Giovanni Armenise-Harvard Foundation Laboratory, via Bonomea 265, 34136 Trieste, Italy)

Abstract

Antisense Uchl1, a long non-coding RNA that is an antisense transcript for the Uchl1 gene, upregulates UCHL1 protein levels through the combined action of an overlapping sequence at its 5′ end and an embedded SINEB2 element.

Suggested Citation

  • Claudia Carrieri & Laura Cimatti & Marta Biagioli & Anne Beugnet & Silvia Zucchelli & Stefania Fedele & Elisa Pesce & Isidre Ferrer & Licio Collavin & Claudio Santoro & Alistair R. R. Forrest & Piero , 2012. "Long non-coding antisense RNA controls Uchl1 translation through an embedded SINEB2 repeat," Nature, Nature, vol. 491(7424), pages 454-457, November.
    • Handle: RePEc:nat:nature:v:491:y:2012:i:7424:d:10.1038_nature11508
    DOI: 10.1038/nature11508
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    Citations

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    Cited by:

    1. Harshita Sharma & Matthew N. Z. Valentine & Naoko Toki & Hiromi Nishiyori Sueki & Stefano Gustincich & Hazuki Takahashi & Piero Carninci, 2024. "Decryption of sequence, structure, and functional features of SINE repeat elements in SINEUP non-coding RNA-mediated post-transcriptional gene regulation," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    2. Yixiao Zhu & Chengmei Huang & Chao Zhang & Yi Zhou & Enen Zhao & Yaxin Zhang & Xingyan Pan & Huilin Huang & Wenting Liao & Xin Wang, 2023. "LncRNA MIR200CHG inhibits EMT in gastric cancer by stabilizing miR-200c from target-directed miRNA degradation," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
    3. Isabel Espadas & Jenna L. Wingfield & Yoshihisa Nakahata & Kaushik Chanda & Eddie Grinman & Ilika Ghosh & Karl E. Bauer & Bindu Raveendra & Michael A. Kiebler & Ryohei Yasuda & Vidhya Rangaraju & Sath, 2024. "Synaptically-targeted long non-coding RNA SLAMR promotes structural plasticity by increasing translation and CaMKII activity," Nature Communications, Nature, vol. 15(1), pages 1-24, December.

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