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Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis

Author

Listed:
  • Rajnish A. Gupta

    (Howard Hughes Medical Institute and Program in Epithelial Biology,)

  • Nilay Shah

    (Sidney Kimmel Comprehensive Cancer Center,)

  • Kevin C. Wang

    (Howard Hughes Medical Institute and Program in Epithelial Biology,)

  • Jeewon Kim

    (Stanford Cancer Center and Transgenic Mouse Research Center,)

  • Hugo M. Horlings

    (Academic Medical Center, Meibergdreef 9, 1105AZ, Amsterdam, The Netherlands)

  • David J. Wong

    (Howard Hughes Medical Institute and Program in Epithelial Biology,)

  • Miao-Chih Tsai

    (Howard Hughes Medical Institute and Program in Epithelial Biology,)

  • Tiffany Hung

    (Howard Hughes Medical Institute and Program in Epithelial Biology,)

  • Pedram Argani

    (Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA)

  • John L. Rinn

    (The Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA)

  • Yulei Wang

    (Applied Biosystems, Foster City, California 94404, USA)

  • Pius Brzoska

    (Applied Biosystems, Foster City, California 94404, USA)

  • Benjamin Kong

    (Applied Biosystems, Foster City, California 94404, USA)

  • Rui Li

    (Stanford University School of Medicine, Stanford, California 94305, USA)

  • Robert B. West

    (Stanford University School of Medicine, Stanford, California 94305, USA)

  • Marc J. van de Vijver

    (Academic Medical Center, Meibergdreef 9, 1105AZ, Amsterdam, The Netherlands)

  • Saraswati Sukumar

    (Sidney Kimmel Comprehensive Cancer Center,)

  • Howard Y. Chang

    (Howard Hughes Medical Institute and Program in Epithelial Biology,)

Abstract

Chromatin in cancer metastasis Long non-coding RNAs (lincRNAs), a relatively recently recognized class of widely transcribed genes, are thought to affect chromatin state and epigenetic regulation, but their mechanisms of action and potential roles in human disease are poorly understood. This study shows that long non-coding RNAs in the human HOX loci are systematically dysregulated during breast cancer progression, and that expression levels of the lincRNA termed HOTAIR can predict cancer metastasis. Elevated levels of HOTAIR can lead to altered patterns of Polycomb binding to the genome. These findings indicate that lincRNAs have active roles in modulating the cancer epigenome and may be important targets for cancer diagnosis and therapy.

Suggested Citation

  • Rajnish A. Gupta & Nilay Shah & Kevin C. Wang & Jeewon Kim & Hugo M. Horlings & David J. Wong & Miao-Chih Tsai & Tiffany Hung & Pedram Argani & John L. Rinn & Yulei Wang & Pius Brzoska & Benjamin Kong, 2010. "Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis," Nature, Nature, vol. 464(7291), pages 1071-1076, April.
    • Handle: RePEc:nat:nature:v:464:y:2010:i:7291:d:10.1038_nature08975
    DOI: 10.1038/nature08975
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    Cited by:

    1. Lei Hu & Shu-Hui Chen & Qiao-Li Lv & Bao Sun & Qiang Qu & Chong-Zhen Qin & Lan Fan & Ying Guo & Lin Cheng & Hong-Hao Zhou, 2016. "Clinical Significance of Long Non-Coding RNA CASC8 rs10505477 Polymorphism in Lung Cancer Susceptibility, Platinum-Based Chemotherapy Response, and Toxicity," IJERPH, MDPI, vol. 13(6), pages 1-12, May.
    2. Ye-Lin Liang & Yuan Zhang & Xi-Rong Tan & Han Qiao & Song-Ran Liu & Ling-Long Tang & Yan-Ping Mao & Lei Chen & Wen-Fei Li & Guan-Qun Zhou & Yin Zhao & Jun-Yan Li & Qian Li & Sheng-Yan Huang & Sha Gong, 2022. "A lncRNA signature associated with tumor immune heterogeneity predicts distant metastasis in locoregionally advanced nasopharyngeal carcinoma," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    3. Feng Zhi & Qiang Wang & Lian Xue & Naiyuan Shao & Rong Wang & Danni Deng & Suinuan Wang & Xiwei Xia & Yilin Yang, 2015. "The Use of Three Long Non-Coding RNAs as Potential Prognostic Indicators of Astrocytoma," PLOS ONE, Public Library of Science, vol. 10(8), pages 1-14, August.
    4. Yixiao Zhu & Chengmei Huang & Chao Zhang & Yi Zhou & Enen Zhao & Yaxin Zhang & Xingyan Pan & Huilin Huang & Wenting Liao & Xin Wang, 2023. "LncRNA MIR200CHG inhibits EMT in gastric cancer by stabilizing miR-200c from target-directed miRNA degradation," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
    5. Gayani Batugedara & Xueqing M. Lu & Borislav Hristov & Steven Abel & Zeinab Chahine & Thomas Hollin & Desiree Williams & Tina Wang & Anthony Cort & Todd Lenz & Trevor A. Thompson & Jacques Prudhomme &, 2023. "Novel insights into the role of long non-coding RNA in the human malaria parasite, Plasmodium falciparum," Nature Communications, Nature, vol. 14(1), pages 1-19, December.

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