IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v14y2023i1d10.1038_s41467-023-43428-3.html
   My bibliography  Save this article

Occlusive membranes for guided regeneration of inflamed tissue defects

Author

Listed:
  • Woojin Choi

    (Yonsei University)

  • Utkarsh Mangal

    (Yonsei University College of Dentistry)

  • Jin-Young Park

    (Yonsei University College of Dentistry)

  • Ji-Yeong Kim

    (Yonsei University College of Dentistry)

  • Taesuk Jun

    (Yonsei University)

  • Ju Won Jung

    (Seoul National University)

  • Moonhyun Choi

    (Yonsei University)

  • Sungwon Jung

    (Yonsei University)

  • Milae Lee

    (Yonsei University)

  • Ji-Yeong Na

    (Yonsei University College of Dentistry)

  • Du Yeol Ryu

    (Yonsei University)

  • Jin Man Kim

    (Seoul National University)

  • Jae-Sung Kwon

    (Yonsei University College of Dentistry)

  • Won-Gun Koh

    (Yonsei University)

  • Sangmin Lee

    (Heukserok-ro, Dongjak-gu)

  • Patrick T. J. Hwang

    (Rowan University)

  • Kee-Joon Lee

    (Yonsei University College of Dentistry)

  • Ui-Won Jung

    (Yonsei University College of Dentistry)

  • Jae-Kook Cha

    (Yonsei University College of Dentistry)

  • Sung-Hwan Choi

    (Yonsei University College of Dentistry)

  • Jinkee Hong

    (Yonsei University)

Abstract

Guided bone regeneration aided by the application of occlusive membranes is a promising therapy for diverse inflammatory periodontal diseases. Symbiosis, homeostasis between the host microbiome and cells, occurs in the oral environment under normal, but not pathologic, conditions. Here, we develop a symbiotically integrating occlusive membrane by mimicking the tooth enamel growth or multiple nucleation biomineralization processes. We perform human saliva and in vivo canine experiments to confirm that the symbiotically integrating occlusive membrane induces a symbiotic healing environment. Moreover, we show that the membrane exhibits tractability and enzymatic stability, maintaining the healing space during the entire guided bone regeneration therapy period. We apply the symbiotically integrating occlusive membrane to treat inflammatory-challenged cases in vivo, namely, the open and closed healing of canine premolars with severe periodontitis. We find that the membrane promotes symbiosis, prevents negative inflammatory responses, and improves cellular integration. Finally, we show that guided bone regeneration therapy with the symbiotically integrating occlusive membrane achieves fast healing of gingival soft tissue and alveolar bone.

Suggested Citation

  • Woojin Choi & Utkarsh Mangal & Jin-Young Park & Ji-Yeong Kim & Taesuk Jun & Ju Won Jung & Moonhyun Choi & Sungwon Jung & Milae Lee & Ji-Yeong Na & Du Yeol Ryu & Jin Man Kim & Jae-Sung Kwon & Won-Gun K, 2023. "Occlusive membranes for guided regeneration of inflamed tissue defects," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
  • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-43428-3
    DOI: 10.1038/s41467-023-43428-3
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-023-43428-3
    File Function: Abstract
    Download Restriction: no

    File URL: https://libkey.io/10.1038/s41467-023-43428-3?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Marianne Liebi & Marios Georgiadis & Andreas Menzel & Philipp Schneider & Joachim Kohlbrecher & Oliver Bunk & Manuel Guizar-Sicairos, 2015. "Nanostructure surveys of macroscopic specimens by small-angle scattering tensor tomography," Nature, Nature, vol. 527(7578), pages 349-352, November.
    2. James T. Morton & Clarisse Marotz & Alex Washburne & Justin Silverman & Livia S. Zaramela & Anna Edlund & Karsten Zengler & Rob Knight, 2019. "Establishing microbial composition measurement standards with reference frames," Nature Communications, Nature, vol. 10(1), pages 1-11, December.
    3. Ovijit Chaudhuri & Justin Cooper-White & Paul A. Janmey & David J. Mooney & Vivek B. Shenoy, 2020. "Effects of extracellular matrix viscoelasticity on cellular behaviour," Nature, Nature, vol. 584(7822), pages 535-546, August.
    4. Bongjun Yeom & Trisha Sain & Naida Lacevic & Daria Bukharina & Sang-Ho Cha & Anthony M. Waas & Ellen M. Arruda & Nicholas A. Kotov, 2017. "Abiotic tooth enamel," Nature, Nature, vol. 543(7643), pages 95-98, March.
    5. Chih-Jung Chang & Chuan-Sheng Lin & Chia-Chen Lu & Jan Martel & Yun-Fei Ko & David M. Ojcius & Shun-Fu Tseng & Tsung-Ru Wu & Yi-Yuan Margaret Chen & John D. Young & Hsin-Chih Lai, 2015. "Ganoderma lucidum reduces obesity in mice by modulating the composition of the gut microbiota," Nature Communications, Nature, vol. 6(1), pages 1-19, November.
    6. Tao Wang & Jiaxiang Bai & Min Lu & Chenglong Huang & Dechun Geng & Gang Chen & Lei Wang & Jin Qi & Wenguo Cui & Lianfu Deng, 2022. "Engineering immunomodulatory and osteoinductive implant surfaces via mussel adhesion-mediated ion coordination and molecular clicking," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Xinyi Fang & Jun Wang & Chengxinyue Ye & Jiu Lin & Jinhui Ran & Zhanrong Jia & Jinglei Gong & Yiming Zhang & Jie Xiang & Xiong Lu & Chaoming Xie & Jin Liu, 2024. "Polyphenol-mediated redox-active hydrogel with H2S gaseous-bioelectric coupling for periodontal bone healing in diabetes," Nature Communications, Nature, vol. 15(1), pages 1-17, December.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Huimin He & Xi Wei & Bin Yang & Hongzhen Liu & Mingze Sun & Yanran Li & Aixin Yan & Chuyang Y. Tang & Yuan Lin & Lizhi Xu, 2022. "Ultrastrong and multifunctional aerogels with hyperconnective network of composite polymeric nanofibers," Nature Communications, Nature, vol. 13(1), pages 1-8, December.
    2. Feipeng Chen & Xiufeng Li & Yafeng Yu & Qingchuan Li & Haisong Lin & Lizhi Xu & Ho Cheung Shum, 2023. "Phase-separation facilitated one-step fabrication of multiscale heterogeneous two-aqueous-phase gel," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    3. Ching Jian & Panu Luukkonen & Hannele Yki-Järvinen & Anne Salonen & Katri Korpela, 2020. "Quantitative PCR provides a simple and accessible method for quantitative microbiota profiling," PLOS ONE, Public Library of Science, vol. 15(1), pages 1-10, January.
    4. Yangteng Ou & Shixiang Cao & Yang Zhang & Hongjia Zhu & Chengzhi Guo & Wei Yan & Fengxue Xin & Weiliang Dong & Yanli Zhang & Masashi Narita & Ziyi Yu & Tuomas P. J. Knowles, 2023. "Bioprinting microporous functional living materials from protein-based core-shell microgels," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    5. Farshad Farshidfar & Kahn Rhrissorrakrai & Chaya Levovitz & Cong Peng & James Knight & Antonella Bacchiocchi & Juan Su & Mingzhu Yin & Mario Sznol & Stephan Ariyan & James Clune & Kelly Olino & Laxmi , 2022. "Integrative molecular and clinical profiling of acral melanoma links focal amplification of 22q11.21 to metastasis," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    6. Wei Zhou & Wen-hui Wu & Zi-lin Si & Hui-ling Liu & Hanyu Wang & Hong Jiang & Ya-fang Liu & Raphael N. Alolga & Cheng Chen & Shi-jia Liu & Xue-yan Bian & Jin-jun Shan & Jing Li & Ning-hua Tan & Zhi-hao, 2022. "The gut microbe Bacteroides fragilis ameliorates renal fibrosis in mice," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
    7. Srinivasan, Arun & Xue, Lingzhou & Zhan, Xiang, 2023. "Identification of microbial features in multivariate regression under false discovery rate control," Computational Statistics & Data Analysis, Elsevier, vol. 181(C).
    8. Zhao Wang & Jan Lauko & Amanda W. Kijas & Elliot P. Gilbert & Petri Turunen & Ramanathan Yegappan & Dongxiu Zou & Jitendra Mata & Alan E. Rowan, 2023. "Snake venom-defined fibrin architecture dictates fibroblast survival and differentiation," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    9. Woojin Choi & Utkarsh Mangal & Jae-Hun Yu & Jeong-Hyun Ryu & Ji‑Yeong Kim & Taesuk Jun & Yoojin Lee & Heesu Cho & Moonhyun Choi & Milae Lee & Du Yeol Ryu & Sang-Young Lee & Se Yong Jung & Jae-Kook Cha, 2024. "Viscoelastic and antimicrobial dental care bioplastic with recyclable life cycle," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    10. Julien Tap & Franck Lejzerowicz & Aurélie Cotillard & Matthieu Pichaud & Daniel McDonald & Se Jin Song & Rob Knight & Patrick Veiga & Muriel Derrien, 2023. "Global branches and local states of the human gut microbiome define associations with environmental and intrinsic factors," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
    11. Zhinan Mao & Xuewei Bi & Chunhao Yu & Lei Chen & Jie Shen & Yongcan Huang & Zihong Wu & Hui Qi & Juan Guan & Xiong Shu & Binsheng Yu & Yufeng Zheng, 2024. "Mechanically robust and personalized silk fibroin-magnesium composite scaffolds with water-responsive shape-memory for irregular bone regeneration," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    12. Huang Lin & Merete Eggesbø & Shyamal Das Peddada, 2022. "Linear and nonlinear correlation estimators unveil undescribed taxa interactions in microbiome data," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    13. Jeremiah J. Minich & Andreas Härer & Joseph Vechinski & Benjamin W. Frable & Zachary R. Skelton & Emily Kunselman & Michael A. Shane & Daniela S. Perry & Antonio Gonzalez & Daniel McDonald & Rob Knigh, 2022. "Host biology, ecology and the environment influence microbial biomass and diversity in 101 marine fish species," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
    14. Shuang Li & Hongtao Yang & Xinhua Qu & Yu Qin & Aobo Liu & Guo Bao & He Huang & Chaoyang Sun & Jiabao Dai & Junlong Tan & Jiahui Shi & Yan Guan & Wei Pan & Xuenan Gu & Bo Jia & Peng Wen & Xiaogang Wan, 2024. "Multiscale architecture design of 3D printed biodegradable Zn-based porous scaffolds for immunomodulatory osteogenesis," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    15. Karen L. Xu & Nikolas Caprio & Hooman Fallahi & Mohammad Dehghany & Matthew D. Davidson & Lorielle Laforest & Brian C. H. Cheung & Yuqi Zhang & Mingming Wu & Vivek Shenoy & Lin Han & Robert L. Mauck &, 2024. "Microinterfaces in biopolymer-based bicontinuous hydrogels guide rapid 3D cell migration," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    16. Tuo Deng & Dongxiu Gao & Xuemei Song & Zhipeng Zhou & Lixiao Zhou & Maixian Tao & Zexiu Jiang & Lian Yang & Lan Luo & Ankun Zhou & Lin Hu & Hongbo Qin & Mingyi Wu, 2023. "A natural biological adhesive from snail mucus for wound repair," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    17. Wen-Long Sun & Sha Hua & Xin-Yu Li & Liang Shen & Hao Wu & Hong-Fang Ji, 2023. "Microbially produced vitamin B12 contributes to the lipid-lowering effect of silymarin," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    18. Eva Barcelona-Estaje & Mariana A. G. Oliva & Finlay Cunniffe & Aleixandre Rodrigo-Navarro & Paul Genever & Matthew J. Dalby & Pere Roca-Cusachs & Marco Cantini & Manuel Salmeron-Sanchez, 2024. "N-cadherin crosstalk with integrin weakens the molecular clutch in response to surface viscosity," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    19. Xiaofang Jia & Jingwen Song & Wenyan Lv & Jonathan P. Hill & Jun Nakanishi & Katsuhiko Ariga, 2022. "Adaptive liquid interfaces induce neuronal differentiation of mesenchymal stem cells through lipid raft assembly," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
    20. Tatsuya Dokoshi & Yang Chen & Kellen J. Cavagnero & Gibraan Rahman & Daniel Hakim & Samantha Brinton & Hana Schwarz & Elizabeth A. Brown & Alan O’Neill & Yoshiyuki Nakamura & Fengwu Li & Nita H. Salzm, 2024. "Dermal injury drives a skin to gut axis that disrupts the intestinal microbiome and intestinal immune homeostasis in mice," Nature Communications, Nature, vol. 15(1), pages 1-12, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-43428-3. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.