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Polyphenol-mediated redox-active hydrogel with H2S gaseous-bioelectric coupling for periodontal bone healing in diabetes

Author

Listed:
  • Xinyi Fang

    (Sichuan University
    Sichuan University
    Southwest Jiaotong University
    Zhejiang University School of Medicine)

  • Jun Wang

    (Sichuan University)

  • Chengxinyue Ye

    (Sichuan University)

  • Jiu Lin

    (Sichuan University
    Zhejiang University School of Medicine)

  • Jinhui Ran

    (Southwest Jiaotong University)

  • Zhanrong Jia

    (Southwest Jiaotong University
    The Tenth Affiliated Hospital of Southern Medical University)

  • Jinglei Gong

    (Sichuan University)

  • Yiming Zhang

    (Southwest Jiaotong University)

  • Jie Xiang

    (Sichuan University)

  • Xiong Lu

    (Southwest Jiaotong University)

  • Chaoming Xie

    (Southwest Jiaotong University)

  • Jin Liu

    (Sichuan University)

Abstract

Excessive oxidative response, unbalanced immunomodulation, and impaired mesenchymal stem cell function in periodontitis in diabetes makes it a great challenge to achieve integrated periodontal tissue regeneration. Here, a polyphenol-mediated redox-active algin/gelatin hydrogel encapsulating a conductive poly(3,4-ethylenedioxythiopene)-assembled polydopamine-mediated silk microfiber network and a hydrogen sulfide sustained-release system utilizing bovine serum albumin nanoparticles is developed. This hydrogel is found to reverse the hyperglycemic inflammatory microenvironment and enhance functional tissue regeneration in diabetic periodontitis. Polydopamine confers the hydrogel with anti-oxidative and anti-inflammatory activity. The slow, sustained release of hydrogen sulfide from the bovine serum albumin nanoparticles recruits mesenchymal stem cells and promotes subsequent angiogenesis and osteogenesis. Moreover, poly(3,4-ethylenedioxythiopene)-assembled polydopamine-mediated silk microfiber confers the hydrogel with good conductivity, which enables it to transmit endogenous bioelectricity, promote cell arrangement, and increase the inflow of calcium ion. In addition, the synergistic effects of hydrogen sulfide gaseous-bioelectric coupling promotes bone formation by amplifying autophagy in periodontal ligament stem cells and modulating macrophage polarization via lipid metabolism regulation. This study provides innovative insights into the synergistic effects of conductivity, reactive oxygen species scavenging, and hydrogen sulfide on the periodontium in a hyperglycemic inflammatory microenvironment, offering a strategy for the design of gaseous-bioelectric biomaterials to promote functional tissue regeneration in immune-related diseases.

Suggested Citation

  • Xinyi Fang & Jun Wang & Chengxinyue Ye & Jiu Lin & Jinhui Ran & Zhanrong Jia & Jinglei Gong & Yiming Zhang & Jie Xiang & Xiong Lu & Chaoming Xie & Jin Liu, 2024. "Polyphenol-mediated redox-active hydrogel with H2S gaseous-bioelectric coupling for periodontal bone healing in diabetes," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-53290-6
    DOI: 10.1038/s41467-024-53290-6
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    References listed on IDEAS

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    1. Woojin Choi & Utkarsh Mangal & Jin-Young Park & Ji-Yeong Kim & Taesuk Jun & Ju Won Jung & Moonhyun Choi & Sungwon Jung & Milae Lee & Ji-Yeong Na & Du Yeol Ryu & Jin Man Kim & Jae-Sung Kwon & Won-Gun K, 2023. "Occlusive membranes for guided regeneration of inflamed tissue defects," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
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