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Wireless, battery-free, multifunctional integrated bioelectronics for respiratory pathogens monitoring and severity evaluation

Author

Listed:
  • Hu Li

    (City University of Hong Kong
    Beihang University)

  • Huarui Gong

    (Chinese Academy of Sciences
    University of Hong Kong)

  • Tsz Hung Wong

    (City University of Hong Kong)

  • Jingkun Zhou

    (City University of Hong Kong
    Hong Kong Centre for Cerebro-Cardiovascular Health Engineering)

  • Yuqiong Wang

    (Beihang University)

  • Long Lin

    (Peking University)

  • Ying Dou

    (University of Hong Kong)

  • Huiling Jia

    (City University of Hong Kong
    Hong Kong Centre for Cerebro-Cardiovascular Health Engineering)

  • Xingcan Huang

    (City University of Hong Kong)

  • Zhan Gao

    (City University of Hong Kong)

  • Rui Shi

    (City University of Hong Kong)

  • Ya Huang

    (City University of Hong Kong
    Hong Kong Centre for Cerebro-Cardiovascular Health Engineering)

  • Zhenlin Chen

    (City University of Hong Kong)

  • Wooyoung PARK

    (City University of Hong Kong)

  • Ji Yu Li

    (City University of Hong Kong
    Hong Kong Centre for Cerebro-Cardiovascular Health Engineering)

  • Hongwei Chu

    (City University of Hong Kong)

  • Shengxin Jia

    (City University of Hong Kong)

  • Han Wu

    (Beihang University)

  • Mengge Wu

    (City University of Hong Kong)

  • Yiming Liu

    (City University of Hong Kong)

  • Dengfeng Li

    (City University of Hong Kong)

  • Jian Li

    (City University of Hong Kong)

  • Guoqiang Xu

    (City University of Hong Kong)

  • Tianrui Chang

    (Beihang University)

  • Binbin Zhang

    (City University of Hong Kong
    Hong Kong Centre for Cerebro-Cardiovascular Health Engineering)

  • Yuyu Gao

    (City University of Hong Kong)

  • Jingyou Su

    (City University of Hong Kong)

  • Hao Bai

    (Sichuan University)

  • Jie Hu

    (Sichuan University)

  • Chun Ki Yiu

    (City University of Hong Kong
    Hong Kong Centre for Cerebro-Cardiovascular Health Engineering)

  • Chenjie Xu

    (City University of Hong Kong)

  • Wenchuang Hu

    (Sichuan University)

  • Jiandong Huang

    (Chinese Academy of Sciences
    University of Hong Kong
    The University of Hong Kong-Shenzhen Hospital
    Sun Yat-Sen University)

  • Lingqian Chang

    (Beihang University
    Anhui Medical University)

  • Xinge Yu

    (City University of Hong Kong
    Hong Kong Centre for Cerebro-Cardiovascular Health Engineering)

Abstract

The rapid diagnosis of respiratory virus infection through breath and blow remains challenging. Here we develop a wireless, battery-free, multifunctional pathogenic infection diagnosis system (PIDS) for diagnosing SARS-CoV-2 infection and symptom severity by blow and breath within 110 s and 350 s, respectively. The accuracies reach to 100% and 92% for evaluating the infection and symptom severity of 42 participants, respectively. PIDS realizes simultaneous gaseous sample collection, biomarker identification, abnormal physical signs recording and machine learning analysis. We transform PIDS into other miniaturized wearable or portable electronic platforms that may widen the diagnostic modes at home, outdoors and public places. Collectively, we demonstrate a general-purpose technology for rapidly diagnosing respiratory pathogenic infection by breath and blow, alleviating the technical bottleneck of saliva and nasopharyngeal secretions. PIDS may serve as a complementary diagnostic tool for other point-of-care techniques and guide the symptomatic treatment of viral infections.

Suggested Citation

  • Hu Li & Huarui Gong & Tsz Hung Wong & Jingkun Zhou & Yuqiong Wang & Long Lin & Ying Dou & Huiling Jia & Xingcan Huang & Zhan Gao & Rui Shi & Ya Huang & Zhenlin Chen & Wooyoung PARK & Ji Yu Li & Hongwe, 2023. "Wireless, battery-free, multifunctional integrated bioelectronics for respiratory pathogens monitoring and severity evaluation," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
  • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-43189-z
    DOI: 10.1038/s41467-023-43189-z
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    References listed on IDEAS

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