IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v14y2023i1d10.1038_s41467-023-42964-2.html
   My bibliography  Save this article

Altered corollary discharge signaling in the auditory cortex of a mouse model of schizophrenia predisposition

Author

Listed:
  • Brian P. Rummell

    (Goethe University
    Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society)

  • Solmaz Bikas

    (Goethe University)

  • Susanne S. Babl

    (Goethe University)

  • Joseph A. Gogos

    (Columbia University
    Columbia University)

  • Torfi Sigurdsson

    (Goethe University)

Abstract

The ability to distinguish sensations that are self-generated from those caused by external events is disrupted in schizophrenia patients. However, the neural circuit abnormalities underlying this sensory impairment and its relationship to the risk factors for the disease is not well understood. To address this, we examined the processing of self-generated sounds in male Df(16)A+/− mice, which model one of the largest genetic risk factors for schizophrenia, the 22q11.2 microdeletion. We find that auditory cortical neurons in Df(16)A+/− mice fail to attenuate their responses to self-generated sounds, recapitulating deficits seen in schizophrenia patients. Notably, the auditory cortex of Df(16)A+/− mice displayed weaker motor-related signals and received fewer inputs from the motor cortex, suggesting an anatomical basis underlying the sensory deficit. These results provide insights into the mechanisms by which a major genetic risk factor for schizophrenia disrupts the top-down processing of sensory information.

Suggested Citation

  • Brian P. Rummell & Solmaz Bikas & Susanne S. Babl & Joseph A. Gogos & Torfi Sigurdsson, 2023. "Altered corollary discharge signaling in the auditory cortex of a mouse model of schizophrenia predisposition," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-42964-2
    DOI: 10.1038/s41467-023-42964-2
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-023-42964-2
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-023-42964-2?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Steven J. Eliades & Xiaoqin Wang, 2008. "Neural substrates of vocalization feedback monitoring in primate auditory cortex," Nature, Nature, vol. 453(7198), pages 1102-1106, June.
    2. Torfi Sigurdsson & Kimberly L. Stark & Maria Karayiorgou & Joseph A. Gogos & Joshua A. Gordon, 2010. "Impaired hippocampal–prefrontal synchrony in a genetic mouse model of schizophrenia," Nature, Nature, vol. 464(7289), pages 763-767, April.
    3. Koun Onodera & Hiroyuki K. Kato, 2022. "Translaminar recurrence from layer 5 suppresses superficial cortical layers," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    4. David M. Schneider & Anders Nelson & Richard Mooney, 2014. "A synaptic and circuit basis for corollary discharge in the auditory cortex," Nature, Nature, vol. 513(7517), pages 189-194, September.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Francisco García-Rosales & Luciana López-Jury & Eugenia González-Palomares & Johannes Wetekam & Yuranny Cabral-Calderín & Ava Kiai & Manfred Kössl & Julio C. Hechavarría, 2022. "Echolocation-related reversal of information flow in a cortical vocalization network," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    2. Evan S. Schaffer & Neeli Mishra & Matthew R. Whiteway & Wenze Li & Michelle B. Vancura & Jason Freedman & Kripa B. Patel & Venkatakaushik Voleti & Liam Paninski & Elizabeth M. C. Hillman & L. F. Abbot, 2023. "The spatial and temporal structure of neural activity across the fly brain," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    3. Irina Pochinok & Tristan M. Stöber & Jochen Triesch & Mattia Chini & Ileana L. Hanganu-Opatz, 2024. "A developmental increase of inhibition promotes the emergence of hippocampal ripples," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    4. Zhaoran Zhang & Edward Zagha, 2023. "Motor cortex gates distractor stimulus encoding in sensory cortex," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    5. Roberto de la Torre-Martinez & Maya Ketzef & Gilad Silberberg, 2023. "Ongoing movement controls sensory integration in the dorsolateral striatum," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    6. Jean-François Patri & Pascal Perrier & Jean-Luc Schwartz & Julien Diard, 2018. "What drives the perceptual change resulting from speech motor adaptation? Evaluation of hypotheses in a Bayesian modeling framework," PLOS Computational Biology, Public Library of Science, vol. 14(1), pages 1-38, January.
    7. Joji Tsunada & Xiaoqin Wang & Steven J. Eliades, 2024. "Multiple processes of vocal sensory-motor interaction in primate auditory cortex," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    8. Noel Federman & Sebastián A. Romano & Macarena Amigo-Duran & Lucca Salomon & Antonia Marin-Burgin, 2024. "Acquisition of non-olfactory encoding improves odour discrimination in olfactory cortex," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    9. Takahiro Shimizu & Stuart G. Nayar & Matthew Swire & Yi Jiang & Matthew Grist & Malte Kaller & Cassandra Sampaio Baptista & David M. Bannerman & Heidi Johansen-Berg & Katsutoshi Ogasawara & Koujiro To, 2023. "Oligodendrocyte dynamics dictate cognitive performance outcomes of working memory training in mice," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
    10. Christopher F. Angeloni & Wiktor Młynarski & Eugenio Piasini & Aaron M. Williams & Katherine C. Wood & Linda Garami & Ann M. Hermundstad & Maria N. Geffen, 2023. "Dynamics of cortical contrast adaptation predict perception of signals in noise," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
    11. Bartul Mimica & Tuçe Tombaz & Claudia Battistin & Jingyi Guo Fuglstad & Benjamin A. Dunn & Jonathan R. Whitlock, 2023. "Behavioral decomposition reveals rich encoding structure employed across neocortex in rats," Nature Communications, Nature, vol. 14(1), pages 1-20, December.
    12. M. Angeles Rabadan & Estanislao Daniel De La Cruz & Sneha B. Rao & Yannan Chen & Cheng Gong & Gregg Crabtree & Bin Xu & Sander Markx & Joseph A. Gogos & Rafael Yuste & Raju Tomer, 2022. "An in vitro model of neuronal ensembles," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    13. Maria Wilhelm & Yaroslav Sych & Aleksejs Fomins & José Luis Alatorre Warren & Christopher Lewis & Laia Serratosa Capdevila & Roman Boehringer & Elizabeth A. Amadei & Benjamin Grewe & Eoin C. O’Connor , 2023. "Striatum-projecting prefrontal cortex neurons support working memory maintenance," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    14. Michele N. Insanally & Badr F. Albanna & Jade Toth & Brian DePasquale & Saba Shokat Fadaei & Trisha Gupta & Olivia Lombardi & Kishore Kuchibhotla & Kanaka Rajan & Robert C. Froemke, 2024. "Contributions of cortical neuron firing patterns, synaptic connectivity, and plasticity to task performance," Nature Communications, Nature, vol. 15(1), pages 1-21, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-42964-2. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.