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Multiple processes of vocal sensory-motor interaction in primate auditory cortex

Author

Listed:
  • Joji Tsunada

    (University of Pennsylvania Perelman School of Medicine
    Chinese Institute for Brain Research)

  • Xiaoqin Wang

    (Johns Hopkins University School of Medicine)

  • Steven J. Eliades

    (University of Pennsylvania Perelman School of Medicine
    Duke University School of Medicine)

Abstract

Sensory-motor interactions in the auditory system play an important role in vocal self-monitoring and control. These result from top-down corollary discharges, relaying predictions about vocal timing and acoustics. Recent evidence suggests such signals may be two distinct processes, one suppressing neural activity during vocalization and another enhancing sensitivity to sensory feedback, rather than a single mechanism. Single-neuron recordings have been unable to disambiguate due to overlap of motor signals with sensory inputs. Here, we sought to disentangle these processes in marmoset auditory cortex during production of multi-phrased ‘twitter’ vocalizations. Temporal responses revealed two timescales of vocal suppression: temporally-precise phasic suppression during phrases and sustained tonic suppression. Both components were present within individual neurons, however, phasic suppression presented broadly regardless of frequency tuning (gating), while tonic was selective for vocal frequencies and feedback (prediction). This suggests that auditory cortex is modulated by concurrent corollary discharges during vocalization, with different computational mechanisms.

Suggested Citation

  • Joji Tsunada & Xiaoqin Wang & Steven J. Eliades, 2024. "Multiple processes of vocal sensory-motor interaction in primate auditory cortex," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
  • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-47510-2
    DOI: 10.1038/s41467-024-47510-2
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    References listed on IDEAS

    as
    1. Steven J. Eliades & Xiaoqin Wang, 2008. "Neural substrates of vocalization feedback monitoring in primate auditory cortex," Nature, Nature, vol. 453(7198), pages 1102-1106, June.
    2. David M. Schneider & Janani Sundararajan & Richard Mooney, 2018. "A cortical filter that learns to suppress the acoustic consequences of movement," Nature, Nature, vol. 561(7723), pages 391-395, September.
    3. Steffen R. Hage & Andreas Nieder, 2013. "Single neurons in monkey prefrontal cortex encode volitional initiation of vocalizations," Nature Communications, Nature, vol. 4(1), pages 1-11, December.
    4. Steven J. Eliades & Joji Tsunada, 2018. "Auditory cortical activity drives feedback-dependent vocal control in marmosets," Nature Communications, Nature, vol. 9(1), pages 1-13, December.
    5. James F. A. Poulet & Berthold Hedwig, 2002. "A corollary discharge maintains auditory sensitivity during sound production," Nature, Nature, vol. 418(6900), pages 872-876, August.
    Full references (including those not matched with items on IDEAS)

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