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Impaired hippocampal–prefrontal synchrony in a genetic mouse model of schizophrenia

Author

Listed:
  • Torfi Sigurdsson

    (Department of Psychiatry,)

  • Kimberly L. Stark

    (Department of Psychiatry,
    Department of Physiology and Cellular Biophysics,)

  • Maria Karayiorgou

    (Department of Psychiatry,
    New York State Psychiatric Institute, New York, New York 10032, USA)

  • Joseph A. Gogos

    (Department of Physiology and Cellular Biophysics,
    College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA)

  • Joshua A. Gordon

    (Department of Psychiatry,
    New York State Psychiatric Institute, New York, New York 10032, USA)

Abstract

Schizophrenia connections The 22q11.2 microdeletion is one of the most reliable known genetic risk factors for schizophrenia. Mice with a disruption in the equivalent chromosomal region have problems with working memory, one feature of schizophrenia. Sigurdsson et al. show that these mice also have disruptions in synchronous firing between prefrontal cortex and hippocampal neurons, a phenomenon that has been linked to learning and memory, and which is also disrupted in schizophrenia patients. These findings suggest that disruption of communication between these brain regions may underlie schizophrenia, and efforts to ameliorate this disruption may lead to novel treatments.

Suggested Citation

  • Torfi Sigurdsson & Kimberly L. Stark & Maria Karayiorgou & Joseph A. Gogos & Joshua A. Gordon, 2010. "Impaired hippocampal–prefrontal synchrony in a genetic mouse model of schizophrenia," Nature, Nature, vol. 464(7289), pages 763-767, April.
    • Handle: RePEc:nat:nature:v:464:y:2010:i:7289:d:10.1038_nature08855
    DOI: 10.1038/nature08855
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    Citations

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    Cited by:

    1. M. Angeles Rabadan & Estanislao Daniel De La Cruz & Sneha B. Rao & Yannan Chen & Cheng Gong & Gregg Crabtree & Bin Xu & Sander Markx & Joseph A. Gogos & Rafael Yuste & Raju Tomer, 2022. "An in vitro model of neuronal ensembles," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    2. Takahiro Shimizu & Stuart G. Nayar & Matthew Swire & Yi Jiang & Matthew Grist & Malte Kaller & Cassandra Sampaio Baptista & David M. Bannerman & Heidi Johansen-Berg & Katsutoshi Ogasawara & Koujiro To, 2023. "Oligodendrocyte dynamics dictate cognitive performance outcomes of working memory training in mice," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
    3. Irina Pochinok & Tristan M. Stöber & Jochen Triesch & Mattia Chini & Ileana L. Hanganu-Opatz, 2024. "A developmental increase of inhibition promotes the emergence of hippocampal ripples," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    4. Brian P. Rummell & Solmaz Bikas & Susanne S. Babl & Joseph A. Gogos & Torfi Sigurdsson, 2023. "Altered corollary discharge signaling in the auditory cortex of a mouse model of schizophrenia predisposition," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    5. Maria Wilhelm & Yaroslav Sych & Aleksejs Fomins & José Luis Alatorre Warren & Christopher Lewis & Laia Serratosa Capdevila & Roman Boehringer & Elizabeth A. Amadei & Benjamin Grewe & Eoin C. O’Connor , 2023. "Striatum-projecting prefrontal cortex neurons support working memory maintenance," Nature Communications, Nature, vol. 14(1), pages 1-16, December.

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