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Redox signaling-driven modulation of microbial biosynthesis and biocatalysis

Author

Listed:
  • Na Chen

    (Wuhan University)

  • Na Du

    (Wuhan University)

  • Ruichen Shen

    (Hunan University)

  • Tianpei He

    (Wuhan University)

  • Jing Xi

    (Wuhan University)

  • Jie Tan

    (Hunan University)

  • Guangkai Bian

    (Chinese Academy of Sciences)

  • Yanbing Yang

    (Wuhan University)

  • Tiangang Liu

    (Wuhan University)

  • Weihong Tan

    (Hunan University)

  • Lilei Yu

    (Wuhan University)

  • Quan Yuan

    (Wuhan University
    Hunan University)

Abstract

Microbial communication can drive coordinated functions through sensing, analyzing and processing signal information, playing critical roles in biomanufacturing and life evolution. However, it is still a great challenge to develop effective methods to construct a microbial communication system with coordinated behaviors. Here, we report an electron transfer triggered redox communication network consisting of three building blocks including signal router, optical verifier and bio-actuator for microbial metabolism regulation and coordination. In the redox communication network, the Fe3+/Fe2+ redox signal can be dynamically and reversibly transduced, channeling electrons directly and specifically into bio-actuator cells through iron oxidation pathway. The redox communication network drives gene expression of electron transfer proteins and simultaneously facilitates the critical reducing power regeneration in the bio-actuator, thus enabling regulation of microbial metabolism. In this way, the redox communication system efficiently promotes the biomanufacturing yield and CO2 fixation rate of bio-actuator. Furthermore, the results demonstrate that this redox communication strategy is applicable both in co-culture and microbial consortia. The proposed electron transfer triggered redox communication strategy in this work could provide an approach for reducing power regeneration and metabolic optimization and could offer insights into improving biomanufacturing efficiency.

Suggested Citation

  • Na Chen & Na Du & Ruichen Shen & Tianpei He & Jing Xi & Jie Tan & Guangkai Bian & Yanbing Yang & Tiangang Liu & Weihong Tan & Lilei Yu & Quan Yuan, 2023. "Redox signaling-driven modulation of microbial biosynthesis and biocatalysis," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
  • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-42561-3
    DOI: 10.1038/s41467-023-42561-3
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