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Ultra-high-throughput mapping of the chemical space of asymmetric catalysis enables accelerated reaction discovery

Author

Listed:
  • Wenjing Nie

    (Wuhan University)

  • Qiongqiong Wan

    (Wuhan University)

  • Jian Sun

    (Wuhan University)

  • Moran Chen

    (Wuhan University)

  • Ming Gao

    (Wuhan University)

  • Suming Chen

    (Wuhan University)

Abstract

The discovery of highly enantioselective catalysts and elucidating their generality face great challenges due to the complex multidimensional chemical space of asymmetric catalysis and inefficient screening methods. Here, we develop a general strategy for ultra-high-throughput mapping of the chemical space of asymmetric catalysis by escaping the time-consuming chiral chromatography separation. The ultrafast ( ~ 1000 reactions/day) and accurate (median error

Suggested Citation

  • Wenjing Nie & Qiongqiong Wan & Jian Sun & Moran Chen & Ming Gao & Suming Chen, 2023. "Ultra-high-throughput mapping of the chemical space of asymmetric catalysis enables accelerated reaction discovery," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-42446-5
    DOI: 10.1038/s41467-023-42446-5
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    References listed on IDEAS

    as
    1. Corin C. Wagen & Spencer E. McMinn & Eugene E. Kwan & Eric N. Jacobsen, 2022. "Screening for generality in asymmetric catalysis," Nature, Nature, vol. 610(7933), pages 680-686, October.
    2. Jolene P. Reid & Matthew S. Sigman, 2019. "Holistic prediction of enantioselectivity in asymmetric catalysis," Nature, Nature, vol. 571(7765), pages 343-348, July.
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