Substrate multiplexed protein engineering facilitates promiscuous biocatalytic synthesis
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DOI: 10.1038/s41467-022-32789-w
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- Emily E. Wrenbeck & Laura R. Azouz & Timothy A. Whitehead, 2017. "Single-mutation fitness landscapes for an enzyme on multiple substrates reveal specificity is globally encoded," Nature Communications, Nature, vol. 8(1), pages 1-10, August.
- Fuqiang Ma & Meng Ting Chung & Yuan Yao & Robert Nidetz & Lap Man Lee & Allen P. Liu & Yan Feng & Katsuo Kurabayashi & Guang-Yu Yang, 2018. "Efficient molecular evolution to generate enantioselective enzymes using a dual-channel microfluidic droplet screening platform," Nature Communications, Nature, vol. 9(1), pages 1-8, December.
- Corin C. Wagen & Spencer E. McMinn & Eugene E. Kwan & Eric N. Jacobsen, 2022. "Screening for generality in asymmetric catalysis," Nature, Nature, vol. 610(7933), pages 680-686, October.
- Linfeng Xu & Kai-Chun Chang & Emory M. Payne & Cyrus Modavi & Leqian Liu & Claire M. Palmer & Nannan Tao & Hal S. Alper & Robert T. Kennedy & Dale S. Cornett & Adam R. Abate, 2021. "Mapping enzyme catalysis with metabolic biosensing," Nature Communications, Nature, vol. 12(1), pages 1-7, December.
- Edward Kalkreuter & Kyle S. Bingham & Aaron M. Keeler & Andrew N. Lowell & Jennifer J. Schmidt & David H. Sherman & Gavin J. Williams, 2021. "Computationally-guided exchange of substrate selectivity motifs in a modular polyketide synthase acyltransferase," Nature Communications, Nature, vol. 12(1), pages 1-12, December.
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