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Unique astrocyte ribbon in adult human brain contains neural stem cells but lacks chain migration

Author

Listed:
  • Nader Sanai

    (Department of Neurological Surgery and Brain Tumor Research Center
    University of California San Francisco)

  • Anthony D. Tramontin

    (Department of Neurological Surgery and Brain Tumor Research Center
    University of California San Francisco)

  • Alfredo Quiñones-Hinojosa

    (Department of Neurological Surgery and Brain Tumor Research Center)

  • Nicholas M. Barbaro

    (Department of Neurological Surgery and Brain Tumor Research Center)

  • Nalin Gupta

    (Department of Neurological Surgery and Brain Tumor Research Center)

  • Sandeep Kunwar

    (Department of Neurological Surgery and Brain Tumor Research Center)

  • Michael T. Lawton

    (Department of Neurological Surgery and Brain Tumor Research Center)

  • Michael W. McDermott

    (Department of Neurological Surgery and Brain Tumor Research Center)

  • Andrew T. Parsa

    (Department of Neurological Surgery and Brain Tumor Research Center)

  • José Manuel-García Verdugo

    (University of Valencia)

  • Mitchel S. Berger

    (Department of Neurological Surgery and Brain Tumor Research Center)

  • Arturo Alvarez-Buylla

    (Department of Neurological Surgery and Brain Tumor Research Center
    University of California San Francisco)

Abstract

The subventricular zone (SVZ) is a principal source of adult neural stem cells in the rodent brain, generating thousands of olfactory bulb neurons every day1. If the adult human brain contains a comparable germinal region, this could have considerable implications for future neuroregenerative therapy. Stem cells have been isolated from the human brain2,3,4,5,6,7, but the identity, organization and function of adult neural stem cells in the human SVZ are unknown. Here we describe a ribbon of SVZ astrocytes lining the lateral ventricles of the adult human brain that proliferate in vivo and behave as multipotent progenitor cells in vitro. This astrocytic ribbon has not been observed in other vertebrates studied. Unexpectedly, we find no evidence of chains of migrating neuroblasts in the SVZ or in the pathway to the olfactory bulb. Our work identifies SVZ astrocytes as neural stem cells in a niche of unique organization in the adult human brain.

Suggested Citation

  • Nader Sanai & Anthony D. Tramontin & Alfredo Quiñones-Hinojosa & Nicholas M. Barbaro & Nalin Gupta & Sandeep Kunwar & Michael T. Lawton & Michael W. McDermott & Andrew T. Parsa & José Manuel-García Ve, 2004. "Unique astrocyte ribbon in adult human brain contains neural stem cells but lacks chain migration," Nature, Nature, vol. 427(6976), pages 740-744, February.
    • Handle: RePEc:nat:nature:v:427:y:2004:i:6976:d:10.1038_nature02301
    DOI: 10.1038/nature02301
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    Cited by:

    1. Michael R. Williamson & Stephanie P. Le & Ronald L. Franzen & Nicole A. Donlan & Jill L. Rosow & Mathilda S. Nicot-Cartsonis & Alexis Cervantes & Benjamin Deneen & Andrew K. Dunn & Theresa A. Jones & , 2023. "Subventricular zone cytogenesis provides trophic support for neural repair in a mouse model of stroke," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    2. Erica Butti & Stefano Cattaneo & Marco Bacigaluppi & Marco Cambiaghi & Giulia Maria Scotti & Elena Brambilla & Francesca Ruffini & Giacomo Sferruzza & Maddalena Ripamonti & Fabio Simeoni & Laura Cacci, 2022. "Neural precursor cells tune striatal connectivity through the release of IGFBPL1," Nature Communications, Nature, vol. 13(1), pages 1-23, December.

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