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Neurosphere-derived multipotent precursors promote neuroprotection by an immunomodulatory mechanism

Author

Listed:
  • Stefano Pluchino

    (Neuroimmunology Unit–DIBIT and)

  • Lucia Zanotti

    (Neuroimmunology Unit–DIBIT and)

  • Barbara Rossi

    (University of Verona)

  • Elena Brambilla

    (Neuroimmunology Unit–DIBIT and)

  • Linda Ottoboni

    (University of Verona)

  • Giuliana Salani

    (Neuroimmunology Unit–DIBIT and)

  • Marianna Martinello

    (University of Verona)

  • Alessandro Cattalini

    (Neuroimmunology Unit–DIBIT and)

  • Alessandra Bergami

    (Neuroimmunology Unit–DIBIT and)

  • Roberto Furlan

    (Neuroimmunology Unit–DIBIT and
    Vita-Salute University, San Raffaele Hospital)

  • Giancarlo Comi

    (Vita-Salute University, San Raffaele Hospital)

  • Gabriela Constantin

    (University of Verona)

  • Gianvito Martino

    (Neuroimmunology Unit–DIBIT and
    Vita-Salute University, San Raffaele Hospital)

Abstract

Stem cells steady the nerves The potential for stem-cell therapy in neurological disorders characterized by chronic inflammation, for example multiple sclerosis, brain tumours and ischaemic stroke, seems limited. Recurring inflammation is likely to destroy both resident and transplanted cells. But in a mouse model of chronic central nervous system inflammation, neural multipotent (stem) precursor cells have been found to promote neuroprotection by maintaining undifferentiated features and exerting unexpected immune-like functions. The undifferentiated cells survive repeated episodes of inflammation, suggesting that they could after all have therapeutic potential in these disorders.

Suggested Citation

  • Stefano Pluchino & Lucia Zanotti & Barbara Rossi & Elena Brambilla & Linda Ottoboni & Giuliana Salani & Marianna Martinello & Alessandro Cattalini & Alessandra Bergami & Roberto Furlan & Giancarlo Com, 2005. "Neurosphere-derived multipotent precursors promote neuroprotection by an immunomodulatory mechanism," Nature, Nature, vol. 436(7048), pages 266-271, July.
    • Handle: RePEc:nat:nature:v:436:y:2005:i:7048:d:10.1038_nature03889
    DOI: 10.1038/nature03889
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    Cited by:

    1. Michael R. Williamson & Stephanie P. Le & Ronald L. Franzen & Nicole A. Donlan & Jill L. Rosow & Mathilda S. Nicot-Cartsonis & Alexis Cervantes & Benjamin Deneen & Andrew K. Dunn & Theresa A. Jones & , 2023. "Subventricular zone cytogenesis provides trophic support for neural repair in a mouse model of stroke," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    2. Marco Luciani & Chiara Garsia & Stefano Beretta & Ingrid Cifola & Clelia Peano & Ivan Merelli & Luca Petiti & Annarita Miccio & Vasco Meneghini & Angela Gritti, 2024. "Human iPSC-derived neural stem cells displaying radial glia signature exhibit long-term safety in mice," Nature Communications, Nature, vol. 15(1), pages 1-24, December.

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