Signature-driven repurposing of Midostaurin for combination with MEK1/2 and KRASG12C inhibitors in lung cancer
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DOI: 10.1038/s41467-023-41828-z
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- Ping Gao & Irina Tchernyshyov & Tsung-Cheng Chang & Yun-Sil Lee & Kayoko Kita & Takafumi Ochi & Karen I. Zeller & Angelo M. De Marzo & Jennifer E. Van Eyk & Joshua T. Mendell & Chi V. Dang, 2009. "c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism," Nature, Nature, vol. 458(7239), pages 762-765, April.
- Jordi Bertran-Alamillo & Valérie Cattan & Marie Schoumacher & Jordi Codony-Servat & Ana Giménez-Capitán & Frédérique Cantero & Mike Burbridge & Sonia Rodríguez & Cristina Teixidó & Ruth Roman & Josep , 2019. "AURKB as a target in non-small cell lung cancer with acquired resistance to anti-EGFR therapy," Nature Communications, Nature, vol. 10(1), pages 1-14, December.
- Yulei Zhao & Yonina R. Murciano-Goroff & Jenny Y. Xue & Agnes Ang & Jessica Lucas & Trang T. Mai & Arnaud F. Cruz Paula & Anne Y. Saiki & Deanna Mohn & Pragathi Achanta & Ann E. Sisk & Kanika S. Arora, 2021. "Diverse alterations associated with resistance to KRAS(G12C) inhibition," Nature, Nature, vol. 599(7886), pages 679-683, November.
- Smyth Gordon K, 2004. "Linear Models and Empirical Bayes Methods for Assessing Differential Expression in Microarray Experiments," Statistical Applications in Genetics and Molecular Biology, De Gruyter, vol. 3(1), pages 1-28, February.
- Jude Canon & Karen Rex & Anne Y. Saiki & Christopher Mohr & Keegan Cooke & Dhanashri Bagal & Kevin Gaida & Tyler Holt & Charles G. Knutson & Neelima Koppada & Brian A. Lanman & Jonathan Werner & Aaron, 2019. "The clinical KRAS(G12C) inhibitor AMG 510 drives anti-tumour immunity," Nature, Nature, vol. 575(7781), pages 217-223, November.
- Neil Vasan & José Baselga & David M. Hyman, 2019. "A view on drug resistance in cancer," Nature, Nature, vol. 575(7782), pages 299-309, November.
- Li Ding & Gad Getz & David A. Wheeler & Elaine R. Mardis & Michael D. McLellan & Kristian Cibulskis & Carrie Sougnez & Heidi Greulich & Donna M. Muzny & Margaret B. Morgan & Lucinda Fulton & Robert S., 2008. "Somatic mutations affect key pathways in lung adenocarcinoma," Nature, Nature, vol. 455(7216), pages 1069-1075, October.
- Xiangjun Kong & Thomas Kuilman & Aida Shahrabi & Julia Boshuizen & Kristel Kemper & Ji-Ying Song & Hans W. M. Niessen & Elisa A. Rozeman & Marnix H. Geukes Foppen & Christian U. Blank & Daniel S. Peep, 2017. "Cancer drug addiction is relayed by an ERK2-dependent phenotype switch," Nature, Nature, vol. 550(7675), pages 270-274, October.
- Yingyao Zhou & Bin Zhou & Lars Pache & Max Chang & Alireza Hadj Khodabakhshi & Olga Tanaseichuk & Christopher Benner & Sumit K. Chanda, 2019. "Metascape provides a biologist-oriented resource for the analysis of systems-level datasets," Nature Communications, Nature, vol. 10(1), pages 1-10, December.
- Curtis R. Chong & David J. Sullivan, 2007. "New uses for old drugs," Nature, Nature, vol. 448(7154), pages 645-646, August.
- Adrian Vallejo & Naiara Perurena & Elisabet Guruceaga & Pawel K. Mazur & Susana Martinez-Canarias & Carolina Zandueta & Karmele Valencia & Andrea Arricibita & Dana Gwinn & Leanne C. Sayles & Chen-Hua , 2017. "An integrative approach unveils FOSL1 as an oncogene vulnerability in KRAS-driven lung and pancreatic cancer," Nature Communications, Nature, vol. 8(1), pages 1-14, April.
- Eusebio Manchado & Susann Weissmueller & John P. Morris & Chi-Chao Chen & Ramona Wullenkord & Amaia Lujambio & Elisa de Stanchina & John T. Poirier & Justin F. Gainor & Ryan B. Corcoran & Jeffrey A. E, 2016. "A combinatorial strategy for treating KRAS-mutant lung cancer," Nature, Nature, vol. 534(7609), pages 647-651, June.
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