IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v458y2009i7239d10.1038_nature07823.html
   My bibliography  Save this article

c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism

Author

Listed:
  • Ping Gao

    (Division of Hematology, Department of Medicine,)

  • Irina Tchernyshyov

    (Division of Cardiology, Department of Medicine,)

  • Tsung-Cheng Chang

    (McKusick-Nathans Institute of Genetic Medicine,)

  • Yun-Sil Lee

    (McKusick-Nathans Institute of Genetic Medicine,)

  • Kayoko Kita

    (Laboratory of Toxicology, Faculty of Pharmaceutical Sciences, Teikyo University, Sagamiko, Kanagawa 229-0195, Japan)

  • Takafumi Ochi

    (Laboratory of Toxicology, Faculty of Pharmaceutical Sciences, Teikyo University, Sagamiko, Kanagawa 229-0195, Japan)

  • Karen I. Zeller

    (Division of Hematology, Department of Medicine,)

  • Angelo M. De Marzo

    (Departments of Pathology,
    Oncology,
    Urology,)

  • Jennifer E. Van Eyk

    (Division of Cardiology, Department of Medicine,
    Biological Chemistry and,)

  • Joshua T. Mendell

    (McKusick-Nathans Institute of Genetic Medicine,
    Departments of Pediatrics and,
    Molecular Biology and Genetics,)

  • Chi V. Dang

    (Division of Hematology, Department of Medicine,
    McKusick-Nathans Institute of Genetic Medicine,
    Molecular Biology and Genetics,
    Departments of Pathology,)

Abstract

c-Myc links cancer to metabolism c-Myc is an oncogene involved in many forms of cancer. Proteomic analysis of human P-493 B lymphoma cells and PC3 prostate cancer cells shows that c-Myc regulates the microRNAs miR-23a and miR-23b to increase the expression of the mitochondrial enzyme glutaminase. This leads to enhanced glutamine metabolism and contributes to the metabolic changes in Myc-driven cancers.

Suggested Citation

  • Ping Gao & Irina Tchernyshyov & Tsung-Cheng Chang & Yun-Sil Lee & Kayoko Kita & Takafumi Ochi & Karen I. Zeller & Angelo M. De Marzo & Jennifer E. Van Eyk & Joshua T. Mendell & Chi V. Dang, 2009. "c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism," Nature, Nature, vol. 458(7239), pages 762-765, April.
    • Handle: RePEc:nat:nature:v:458:y:2009:i:7239:d:10.1038_nature07823
    DOI: 10.1038/nature07823
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature07823
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature07823?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Irati Macaya & Marta Roman & Connor Welch & Rodrigo Entrialgo-Cadierno & Marina Salmon & Alba Santos & Iker Feliu & Joanna Kovalski & Ines Lopez & Maria Rodriguez-Remirez & Sara Palomino-Echeverria & , 2023. "Signature-driven repurposing of Midostaurin for combination with MEK1/2 and KRASG12C inhibitors in lung cancer," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
    2. Shi Feng & Cody Aplin & Thuy-Tien T. Nguyen & Shawn K. Milano & Richard A. Cerione, 2024. "Filament formation drives catalysis by glutaminase enzymes important in cancer progression," Nature Communications, Nature, vol. 15(1), pages 1-14, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:458:y:2009:i:7239:d:10.1038_nature07823. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.