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c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism

Author

Listed:
  • Ping Gao

    (Division of Hematology, Department of Medicine,)

  • Irina Tchernyshyov

    (Division of Cardiology, Department of Medicine,)

  • Tsung-Cheng Chang

    (McKusick-Nathans Institute of Genetic Medicine,)

  • Yun-Sil Lee

    (McKusick-Nathans Institute of Genetic Medicine,)

  • Kayoko Kita

    (Laboratory of Toxicology, Faculty of Pharmaceutical Sciences, Teikyo University, Sagamiko, Kanagawa 229-0195, Japan)

  • Takafumi Ochi

    (Laboratory of Toxicology, Faculty of Pharmaceutical Sciences, Teikyo University, Sagamiko, Kanagawa 229-0195, Japan)

  • Karen I. Zeller

    (Division of Hematology, Department of Medicine,)

  • Angelo M. De Marzo

    (Departments of Pathology,
    Oncology,
    Urology,)

  • Jennifer E. Van Eyk

    (Division of Cardiology, Department of Medicine,
    Biological Chemistry and,)

  • Joshua T. Mendell

    (McKusick-Nathans Institute of Genetic Medicine,
    Departments of Pediatrics and,
    Molecular Biology and Genetics,)

  • Chi V. Dang

    (Division of Hematology, Department of Medicine,
    McKusick-Nathans Institute of Genetic Medicine,
    Molecular Biology and Genetics,
    Departments of Pathology,)

Abstract

c-Myc links cancer to metabolism c-Myc is an oncogene involved in many forms of cancer. Proteomic analysis of human P-493 B lymphoma cells and PC3 prostate cancer cells shows that c-Myc regulates the microRNAs miR-23a and miR-23b to increase the expression of the mitochondrial enzyme glutaminase. This leads to enhanced glutamine metabolism and contributes to the metabolic changes in Myc-driven cancers.

Suggested Citation

  • Ping Gao & Irina Tchernyshyov & Tsung-Cheng Chang & Yun-Sil Lee & Kayoko Kita & Takafumi Ochi & Karen I. Zeller & Angelo M. De Marzo & Jennifer E. Van Eyk & Joshua T. Mendell & Chi V. Dang, 2009. "c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism," Nature, Nature, vol. 458(7239), pages 762-765, April.
    • Handle: RePEc:nat:nature:v:458:y:2009:i:7239:d:10.1038_nature07823
    DOI: 10.1038/nature07823
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    Cited by:

    1. Irati Macaya & Marta Roman & Connor Welch & Rodrigo Entrialgo-Cadierno & Marina Salmon & Alba Santos & Iker Feliu & Joanna Kovalski & Ines Lopez & Maria Rodriguez-Remirez & Sara Palomino-Echeverria & , 2023. "Signature-driven repurposing of Midostaurin for combination with MEK1/2 and KRASG12C inhibitors in lung cancer," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
    2. Douglas Adamoski & Larissa M. dos Reis & Ana Carolina Paschoalini Mafra & Felipe Corrêa-da-Silva & Pedro Manoel Mendes de Moraes-Vieira & Ioana Berindan-Neagoe & George A. Calin & Sandra Martha Gomes , 2024. "HuR controls glutaminase RNA metabolism," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
    3. Shi Feng & Cody Aplin & Thuy-Tien T. Nguyen & Shawn K. Milano & Richard A. Cerione, 2024. "Filament formation drives catalysis by glutaminase enzymes important in cancer progression," Nature Communications, Nature, vol. 15(1), pages 1-14, December.

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