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Control of locomotor speed, arousal, and hippocampal theta rhythms by the nucleus incertus

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  • Lihui Lu

    (Tsinghua University
    Tsinghua University
    National Institute of Biological Sciences (NIBS))

  • Yuqi Ren

    (Peking University
    Peking University-Tsinghua University-NIBS Joint Graduate Program)

  • Tao Yu

    (Tsinghua University
    National Institute of Biological Sciences (NIBS)
    Peking University-Tsinghua University-NIBS Joint Graduate Program)

  • Zhixiang Liu

    (National Institute of Biological Sciences (NIBS))

  • Sice Wang

    (National Institute of Biological Sciences (NIBS)
    Peking University
    Peking University-Tsinghua University-NIBS Joint Graduate Program)

  • Lubin Tan

    (National Institute of Biological Sciences (NIBS))

  • Jiawei Zeng

    (National Institute of Biological Sciences (NIBS))

  • Qiru Feng

    (Tsinghua University
    National Institute of Biological Sciences (NIBS)
    Peking University-Tsinghua University-NIBS Joint Graduate Program)

  • Rui Lin

    (National Institute of Biological Sciences (NIBS))

  • Yang Liu

    (Tsinghua University
    Tsinghua University
    National Institute of Biological Sciences (NIBS))

  • Qingchun Guo

    (Chinese Institute for Brain Research)

  • Minmin Luo

    (Tsinghua University
    Tsinghua University
    National Institute of Biological Sciences (NIBS)
    Peking University-Tsinghua University-NIBS Joint Graduate Program)

Abstract

Navigation requires not only the execution of locomotor programs but also high arousal and real-time retrieval of spatial memory that is often associated with hippocampal theta oscillations. However, the neural circuits for coordinately controlling these important processes remain to be fully dissected. Here we show that the activity of the neuromedin B (NMB) neurons in the nucleus incertus (NI) is tightly correlated with mouse locomotor speed, arousal level, and hippocampal theta power. These processes are reversibly suppressed by optogenetic inhibition and rapidly promoted by optogenetic stimulation of NI NMB neurons. These neurons form reciprocal connections with several subcortical areas associated with arousal, theta oscillation, and premotor processing. Their projections to multiple downstream stations regulate locomotion and hippocampal theta, with the projection to the medial septum being particularly important for promoting arousal. Therefore, NI NMB neurons functionally impact the neural circuit for navigation control according to particular brains states.

Suggested Citation

  • Lihui Lu & Yuqi Ren & Tao Yu & Zhixiang Liu & Sice Wang & Lubin Tan & Jiawei Zeng & Qiru Feng & Rui Lin & Yang Liu & Qingchun Guo & Minmin Luo, 2020. "Control of locomotor speed, arousal, and hippocampal theta rhythms by the nucleus incertus," Nature Communications, Nature, vol. 11(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-019-14116-y
    DOI: 10.1038/s41467-019-14116-y
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    Cited by:

    1. Bálint Király & Andor Domonkos & Márta Jelitai & Vítor Lopes-dos-Santos & Sergio Martínez-Bellver & Barnabás Kocsis & Dániel Schlingloff & Abhilasha Joshi & Minas Salib & Richárd Fiáth & Péter Barthó , 2023. "The medial septum controls hippocampal supra-theta oscillations," Nature Communications, Nature, vol. 14(1), pages 1-25, December.
    2. Amanda L. Schott & Justin Baik & Shinjae Chung & Franz Weber, 2023. "A medullary hub for controlling REM sleep and pontine waves," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    3. Lizhu Li & Lihui Lu & Yuqi Ren & Guo Tang & Yu Zhao & Xue Cai & Zhao Shi & He Ding & Changbo Liu & Dali Cheng & Yang Xie & Huachun Wang & Xin Fu & Lan Yin & Minmin Luo & Xing Sheng, 2022. "Colocalized, bidirectional optogenetic modulations in freely behaving mice with a wireless dual-color optoelectronic probe," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    4. Stefano Nardone & Roberto Luca & Antonino Zito & Nataliya Klymko & Dimitris Nicoloutsopoulos & Oren Amsalem & Cory Brannigan & Jon M. Resch & Christopher L. Jacobs & Deepti Pant & Molly Veregge & Hari, 2024. "A spatially-resolved transcriptional atlas of the murine dorsal pons at single-cell resolution," Nature Communications, Nature, vol. 15(1), pages 1-21, December.

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