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Ventral hippocampal OLM cells control type 2 theta oscillations and response to predator odor

Author

Listed:
  • Sanja Mikulovic

    (Uppsala University)

  • Carlos Ernesto Restrepo

    (Uppsala University)

  • Samer Siwani

    (Uppsala University)

  • Pavol Bauer

    (Uppsala University)

  • Stefano Pupe

    (Uppsala University
    Federal University of Rio Grande do Norte)

  • Adriano B. L. Tort

    (Federal University of Rio Grande do Norte)

  • Klas Kullander

    (Uppsala University)

  • Richardson N. Leão

    (Uppsala University
    Federal University of Rio Grande do Norte)

Abstract

Dorsal and ventral hippocampus regions exert cognition and emotion-related functions, respectively. Since both regions display rhythmic activity, specific neural oscillatory pacemakers may underlie their functional dichotomy. Type 1 theta oscillations are independent of cholinergic transmission and are observed in the dorsal hippocampus during movement and exploration. In contrast, type 2 theta depends on acetylcholine and appears when animals are exposed to emotionally laden contexts such as a predator presence. Despite its involvement in emotions, type 2 theta has not been associated with the ventral hippocampus. Here, we show that optogenetic activation of oriens-lacunosum moleculare (OLM) interneurons in the ventral hippocampus drives type 2 theta. Moreover, we found that type 2 theta generation is associated with increased risk-taking behavior in response to predator odor. These results demonstrate that two theta oscillations subtypes originate in the two hippocampal regions that predominantly underlie either cognitive or emotion-related functions.

Suggested Citation

  • Sanja Mikulovic & Carlos Ernesto Restrepo & Samer Siwani & Pavol Bauer & Stefano Pupe & Adriano B. L. Tort & Klas Kullander & Richardson N. Leão, 2018. "Ventral hippocampal OLM cells control type 2 theta oscillations and response to predator odor," Nature Communications, Nature, vol. 9(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-05907-w
    DOI: 10.1038/s41467-018-05907-w
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    Cited by:

    1. Kaizhen Li & Konstantinos Koukoutselos & Masanori Sakaguchi & Stéphane Ciocchi, 2024. "Distinct ventral hippocampal inhibitory microcircuits regulating anxiety and fear behaviors," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    2. Bálint Király & Andor Domonkos & Márta Jelitai & Vítor Lopes-dos-Santos & Sergio Martínez-Bellver & Barnabás Kocsis & Dániel Schlingloff & Abhilasha Joshi & Minas Salib & Richárd Fiáth & Péter Barthó , 2023. "The medial septum controls hippocampal supra-theta oscillations," Nature Communications, Nature, vol. 14(1), pages 1-25, December.
    3. Michael S. Totty & Tuğçe Tuna & Karthik R. Ramanathan & Jingji Jin & Shaun E. Peters & Stephen Maren, 2023. "Thalamic nucleus reuniens coordinates prefrontal-hippocampal synchrony to suppress extinguished fear," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    4. Miroslav Stibůrek & Petra Ondráčková & Tereza Tučková & Sergey Turtaev & Martin Šiler & Tomáš Pikálek & Petr Jákl & André Gomes & Jana Krejčí & Petra Kolbábková & Hana Uhlířová & Tomáš Čižmár, 2023. "110 μm thin endo-microscope for deep-brain in vivo observations of neuronal connectivity, activity and blood flow dynamics," Nature Communications, Nature, vol. 14(1), pages 1-9, December.

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