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Photostimulation of brain lymphatics in male newborn and adult rodents for therapy of intraventricular hemorrhage

Author

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  • Dongyu Li

    (Huazhong University of Science and Technology
    Huazhong University of Science and Technology)

  • Shaojun Liu

    (Huazhong University of Science and Technology)

  • Tingting Yu

    (Huazhong University of Science and Technology)

  • Zhang Liu

    (Huazhong University of Science and Technology)

  • Silin Sun

    (Huazhong University of Science and Technology)

  • Denis Bragin

    (Lovelace Biomedical Research Institute
    Department of Neurology University of New Mexico School of Medicine)

  • Alexander Shirokov

    (Russian Academy of Sciences
    Saratov State University)

  • Nikita Navolokin

    (Saratov State University
    Saratov State Medical University)

  • Olga Bragina

    (Lovelace Biomedical Research Institute)

  • Zhengwu Hu

    (Huazhong University of Science and Technology
    Huazhong University of Science and Technology)

  • Jürgen Kurths

    (Saratov State University
    Physics Department, Humboldt University
    Potsdam Institute for Climate Impact Research, Telegrafenberg A31
    Sechenov First Moscow State Medical University)

  • Ivan Fedosov

    (Saratov State University)

  • Inna Blokhina

    (Saratov State University)

  • Alexander Dubrovski

    (Saratov State University)

  • Alexander Khorovodov

    (Saratov State University)

  • Andrey Terskov

    (Saratov State University)

  • Maria Tzoy

    (Saratov State University)

  • Oxana Semyachkina-Glushkovskaya

    (Saratov State University
    Physics Department, Humboldt University)

  • Dan Zhu

    (Huazhong University of Science and Technology)

Abstract

Intraventricular hemorrhage is one of the most fatal forms of brain injury that is a common complication of premature infants. However, the therapy of this type of hemorrhage is limited, and new strategies are needed to reduce hematoma expansion. Here we show that the meningeal lymphatics is a pathway to remove red blood cells from the brain’s ventricular system of male human, adult and newborn rodents and is a target for non-invasive transcranial near infrared photobiomodulation. Our results uncover the clinical significance of phototherapy of intraventricular hemorrhage in 4-day old male rat pups that have the brain similar to a preterm human brain. The course of phototherapy in newborn rats provides fast recovery after intraventricular hemorrhage due to photo-improvements of lymphatic drainage and clearing functions. These findings shed light on the mechanisms of phototherapy of intraventricular hemorrhage that can be a clinically relevant technology for treatment of neonatal intracerebral bleedings.

Suggested Citation

  • Dongyu Li & Shaojun Liu & Tingting Yu & Zhang Liu & Silin Sun & Denis Bragin & Alexander Shirokov & Nikita Navolokin & Olga Bragina & Zhengwu Hu & Jürgen Kurths & Ivan Fedosov & Inna Blokhina & Alexan, 2023. "Photostimulation of brain lymphatics in male newborn and adult rodents for therapy of intraventricular hemorrhage," Nature Communications, Nature, vol. 14(1), pages 1-20, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-41710-y
    DOI: 10.1038/s41467-023-41710-y
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    References listed on IDEAS

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    1. Jinman Chen & Linmei Wang & Hao Xu & Lianping Xing & Zixin Zhuang & Yangkang Zheng & Xuefei Li & Chinyun Wang & Shaohua Chen & Zibin Guo & Qianqian Liang & Yongjun Wang, 2020. "Meningeal lymphatics clear erythrocytes that arise from subarachnoid hemorrhage," Nature Communications, Nature, vol. 11(1), pages 1-15, December.
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    1. Miao Wang & Congcong Yan & Xi Li & Tianhao Yang & Shengnan Wu & Qian Liu & Qingming Luo & Feifan Zhou, 2024. "Non-invasive modulation of meningeal lymphatics ameliorates ageing and Alzheimer’s disease-associated pathology and cognition in mice," Nature Communications, Nature, vol. 15(1), pages 1-14, December.

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