IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v14y2023i1d10.1038_s41467-023-37685-5.html
   My bibliography  Save this article

Plasma neurodegeneration biomarker concentrations associate with glymphatic and meningeal lymphatic measures in neurological disorders

Author

Listed:
  • Per Kristian Eide

    (Oslo University Hospital-Rikshospitalet
    University of Oslo)

  • Aslan Lashkarivand

    (Oslo University Hospital-Rikshospitalet
    University of Oslo)

  • Are Pripp

    (Oslo University Hospital
    Oslo Metropolitan University)

  • Lars Magnus Valnes

    (Oslo University Hospital-Rikshospitalet)

  • Markus Herberg Hovd

    (University of Oslo)

  • Geir Ringstad

    (Oslo University Hospital—Rikshospitalet
    Sorlandet Hospital)

  • Kaj Blennow

    (the Sahlgrenska Academy at the University of Gothenburg
    Sahlgrenska University Hospital)

  • Henrik Zetterberg

    (the Sahlgrenska Academy at the University of Gothenburg
    Sahlgrenska University Hospital
    UCL Institute of Neurology
    UK Dementia Research Institute at UCL)

Abstract

Clearance of neurotoxic brain proteins via cerebrospinal fluid (CSF) to blood has recently emerged to be crucial, and plasma biomarkers of neurodegeneration were newly introduced to predict neurological disease. This study examines in 106 individuals with neurological disorders associations between plasma biomarkers [40 and 42 amino acid-long amyloid-β (Aβ40 and Aβ42), total-tau, glial fibrillary acidic protein (GFAP), and neurofilament light (NfL)] and magnetic resonance imaging measures of CSF-mediated clearance from brain via extra-vascular pathways (proxy of glymphatic function) and CSF-to-blood clearance variables from pharmacokinetic modeling (proxy of meningeal lymphatic egress). We also examine how biomarkers vary during daytime and associate with subjective sleep quality. Plasma concentrations of neurodegeneration markers associate with indices of glymphatic and meningeal lymphatic functions in individual- and disease-specific manners, vary during daytime, but are unaffected by sleep quality. The results suggest that plasma concentrations of neurodegeneration biomarkers associate with measures of glymphatic and meningeal lymphatic function.

Suggested Citation

  • Per Kristian Eide & Aslan Lashkarivand & Are Pripp & Lars Magnus Valnes & Markus Herberg Hovd & Geir Ringstad & Kaj Blennow & Henrik Zetterberg, 2023. "Plasma neurodegeneration biomarker concentrations associate with glymphatic and meningeal lymphatic measures in neurological disorders," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-37685-5
    DOI: 10.1038/s41467-023-37685-5
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-023-37685-5
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-023-37685-5?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Lauren M. Hablitz & Virginia Plá & Michael Giannetto & Hanna S. Vinitsky & Frederik Filip Stæger & Tanner Metcalfe & Rebecca Nguyen & Abdellatif Benrais & Maiken Nedergaard, 2020. "Circadian control of brain glymphatic and lymphatic fluid flow," Nature Communications, Nature, vol. 11(1), pages 1-11, December.
    2. Antoine Louveau & Igor Smirnov & Timothy J. Keyes & Jacob D. Eccles & Sherin J. Rouhani & J. David Peske & Noel C. Derecki & David Castle & James W. Mandell & Kevin S. Lee & Tajie H. Harris & Jonathan, 2015. "Structural and functional features of central nervous system lymphatic vessels," Nature, Nature, vol. 523(7560), pages 337-341, July.
    3. Sandro Mesquita & Antoine Louveau & Andrea Vaccari & Igor Smirnov & R. Chase Cornelison & Kathryn M. Kingsmore & Christian Contarino & Suna Onengut-Gumuscu & Emily Farber & Daniel Raper & Kenneth E. V, 2018. "Functional aspects of meningeal lymphatics in ageing and Alzheimer’s disease," Nature, Nature, vol. 560(7717), pages 185-191, August.
    4. Eric Song & Tianyang Mao & Huiping Dong & Ligia Simoes Braga Boisserand & Salli Antila & Marcus Bosenberg & Kari Alitalo & Jean-Leon Thomas & Akiko Iwasaki, 2020. "VEGF-C-driven lymphatic drainage enables immunosurveillance of brain tumours," Nature, Nature, vol. 577(7792), pages 689-694, January.
    5. Sandro Da Mesquita & Antoine Louveau & Andrea Vaccari & Igor Smirnov & R. Chase Cornelison & Kathryn M. Kingsmore & Christian Contarino & Suna Onengut-Gumuscu & Emily Farber & Daniel Raper & Kenneth E, 2018. "Publisher Correction: Functional aspects of meningeal lymphatics in ageing and Alzheimer’s disease," Nature, Nature, vol. 564(7734), pages 7-7, December.
    6. Sandro Mesquita & Zachary Papadopoulos & Taitea Dykstra & Logan Brase & Fabiana Geraldo Farias & Morgan Wall & Hong Jiang & Chinnappa Dilip Kodira & Kalil Alves Lima & Jasmin Herz & Antoine Louveau & , 2021. "Meningeal lymphatics affect microglia responses and anti-Aβ immunotherapy," Nature, Nature, vol. 593(7858), pages 255-260, May.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Weiping Dai & Mengqian Yang & Pei Xia & Chuan Xiao & Shuying Huang & Zhan Zhang & Xin Cheng & Wenchang Li & Jian Jin & Jingyun Zhang & Binghuo Wu & Yingying Zhang & Pei-hui Wu & Yangyang Lin & Wen Wu , 2022. "A functional role of meningeal lymphatics in sex difference of stress susceptibility in mice," Nature Communications, Nature, vol. 13(1), pages 1-21, December.
    2. Nicola A. Kearns & Artemis Iatrou & Daniel J. Flood & Sashini Tissera & Zachary M. Mullaney & Jishu Xu & Chris Gaiteri & David A. Bennett & Yanling Wang, 2023. "Dissecting the human leptomeninges at single-cell resolution," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    3. Miao Wang & Congcong Yan & Xi Li & Tianhao Yang & Shengnan Wu & Qian Liu & Qingming Luo & Feifan Zhou, 2024. "Non-invasive modulation of meningeal lymphatics ameliorates ageing and Alzheimer’s disease-associated pathology and cognition in mice," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    4. Carolin Beuker & David Schafflick & Jan-Kolja Strecker & Michael Heming & Xiaolin Li & Jolien Wolbert & Antje Schmidt-Pogoda & Christian Thomas & Tanja Kuhlmann & Irene Aranda-Pardos & Noelia A-Gonzal, 2022. "Stroke induces disease-specific myeloid cells in the brain parenchyma and pia," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    5. Nieves Montenegro-Navarro & Claudia García-Báez & Melissa García-Caballero, 2023. "Molecular and metabolic orchestration of the lymphatic vasculature in physiology and pathology," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    6. Chou, Dean & Chen, Po-Yen, 2024. "A machine learning method to explore the glymphatic system via poroelastodynamics," Chaos, Solitons & Fractals, Elsevier, vol. 178(C).
    7. Stefano Suzzi & Tommaso Croese & Adi Ravid & Or Gold & Abbe R. Clark & Sedi Medina & Daniel Kitsberg & Miriam Adam & Katherine A. Vernon & Eva Kohnert & Inbar Shapira & Sergey Malitsky & Maxim Itkin &, 2023. "N-acetylneuraminic acid links immune exhaustion and accelerated memory deficit in diet-induced obese Alzheimer’s disease mouse model," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
    8. Per Kristian Eide & Geir Ringstad, 2024. "Functional analysis of the human perivascular subarachnoid space," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    9. Xiang He & Daiqin Xiong & Lei Zhao & Jialong Fu & Lingfei Luo, 2024. "Meningeal lymphatic supporting cells govern the formation and maintenance of zebrafish mural lymphatic endothelial cells," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    10. Hadi Abou-El-Hassan & Rafael M. Rezende & Saef Izzy & Galina Gabriely & Taha Yahya & Bruna K. Tatematsu & Karl J. Habashy & Juliana R. Lopes & Gislane L. V. Oliveira & Amir-Hadi Maghzi & Zhuoran Yin &, 2023. "Vγ1 and Vγ4 gamma-delta T cells play opposing roles in the immunopathology of traumatic brain injury in males," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
    11. Logan Brase & Shih-Feng You & Ricardo D’Oliveira Albanus & Jorge L. Del-Aguila & Yaoyi Dai & Brenna C. Novotny & Carolina Soriano-Tarraga & Taitea Dykstra & Maria Victoria Fernandez & John P. Budde & , 2023. "Single-nucleus RNA-sequencing of autosomal dominant Alzheimer disease and risk variant carriers," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
    12. Susana Lozano-Tovar & Yaneth Rodríguez-Agudelo & David José Dávila-Ortiz de Montellano & Blanca Estela Pérez-Aldana & Alberto Ortega-Vázquez & Nancy Monroy-Jaramillo, 2023. "Relationship between APOE , PER2 , PER3 and OX2R Genetic Variants and Neuropsychiatric Symptoms in Patients with Alzheimer’s Disease," IJERPH, MDPI, vol. 20(5), pages 1-14, March.
    13. Ryann M. Fame & Peter N. Kalugin & Boryana Petrova & Huixin Xu & Paul A. Soden & Frederick B. Shipley & Neil Dani & Bradford Grant & Aja Pragana & Joshua P. Head & Suhasini Gupta & Morgan L. Shannon &, 2023. "Defining diurnal fluctuations in mouse choroid plexus and CSF at high molecular, spatial, and temporal resolution," Nature Communications, Nature, vol. 14(1), pages 1-20, December.
    14. Josephine A. Mapunda & Javier Pareja & Mykhailo Vladymyrov & Elisa Bouillet & Pauline Hélie & Petr Pleskač & Sara Barcos & Johanna Andrae & Dietmar Vestweber & Donald M. McDonald & Christer Betsholtz , 2023. "VE-cadherin in arachnoid and pia mater cells serves as a suitable landmark for in vivo imaging of CNS immune surveillance and inflammation," Nature Communications, Nature, vol. 14(1), pages 1-23, December.
    15. Geir Ringstad & Per Kristian Eide, 2023. "The pitfalls of interpreting hyperintense FLAIR signal as lymph outside the human brain," Nature Communications, Nature, vol. 14(1), pages 1-3, December.
    16. Qian Sun & Sisi Peng & Qiwu Xu & Pia Weikop & Rashad Hussain & Wei Song & Maiken Nedergaard & Fengfei Ding, 2024. "Enhancing glymphatic fluid transport by pan-adrenergic inhibition suppresses epileptogenesis in male mice," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    17. Anastasia Mozokhina & Rostislav Savinkov, 2020. "Mathematical Modelling of the Structure and Function of the Lymphatic System," Mathematics, MDPI, vol. 8(9), pages 1-18, September.
    18. Shinji Naganawa & Yutaka Kato & Tadao Yoshida & Michihiko Sone, 2023. "Fluid signal suppression characteristics of 3D-FLAIR with a T2 selective inversion pulse in the skull base," Nature Communications, Nature, vol. 14(1), pages 1-3, December.
    19. Dongyu Li & Shaojun Liu & Tingting Yu & Zhang Liu & Silin Sun & Denis Bragin & Alexander Shirokov & Nikita Navolokin & Olga Bragina & Zhengwu Hu & Jürgen Kurths & Ivan Fedosov & Inna Blokhina & Alexan, 2023. "Photostimulation of brain lymphatics in male newborn and adult rodents for therapy of intraventricular hemorrhage," Nature Communications, Nature, vol. 14(1), pages 1-20, December.
    20. Shelei Pan & Peter H. Yang & Dakota DeFreitas & Sruthi Ramagiri & Peter O. Bayguinov & Carl D. Hacker & Abraham Z. Snyder & Jackson Wilborn & Hengbo Huang & Gretchen M. Koller & Dhvanii K. Raval & Gra, 2023. "Gold nanoparticle-enhanced X-ray microtomography of the rodent reveals region-specific cerebrospinal fluid circulation in the brain," Nature Communications, Nature, vol. 14(1), pages 1-16, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-37685-5. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.