IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v572y2019i7767d10.1038_s41586-019-1419-5.html
   My bibliography  Save this article

Meningeal lymphatic vessels at the skull base drain cerebrospinal fluid

Author

Listed:
  • Ji Hoon Ahn

    (Korea Advanced Institute of Science and Technology (KAIST))

  • Hyunsoo Cho

    (Institute for Basic Science)

  • Jun-Hee Kim

    (KAIST)

  • Shin Heun Kim

    (KAIST)

  • Je-Seok Ham

    (KAIST)

  • Intae Park

    (Institute for Basic Science)

  • Sang Heon Suh

    (Korea Advanced Institute of Science and Technology (KAIST))

  • Seon Pyo Hong

    (Institute for Basic Science)

  • Joo-Hye Song

    (Institute for Basic Science)

  • Young-Kwon Hong

    (University of Southern California)

  • Yong Jeong

    (Korea Advanced Institute of Science and Technology (KAIST)
    KAIST
    KAIST)

  • Sung-Hong Park

    (KAIST
    KAIST)

  • Gou Young Koh

    (Korea Advanced Institute of Science and Technology (KAIST)
    Institute for Basic Science)

Abstract

Recent work has shown that meningeal lymphatic vessels (mLVs), mainly in the dorsal part of the skull, are involved in the clearance of cerebrospinal fluid (CSF), but the precise route of CSF drainage is still unknown. Here we reveal the importance of mLVs in the basal part of the skull for this process by visualizing their distinct anatomical location and characterizing their specialized morphological features, which facilitate the uptake and drainage of CSF. Unlike dorsal mLVs, basal mLVs have lymphatic valves and capillaries located adjacent to the subarachnoid space in mice. We also show that basal mLVs are hotspots for the clearance of CSF macromolecules and that both mLV integrity and CSF drainage are impaired with ageing. Our findings should increase the understanding of how mLVs contribute to the neuropathophysiological processes that are associated with ageing.

Suggested Citation

  • Ji Hoon Ahn & Hyunsoo Cho & Jun-Hee Kim & Shin Heun Kim & Je-Seok Ham & Intae Park & Sang Heon Suh & Seon Pyo Hong & Joo-Hye Song & Young-Kwon Hong & Yong Jeong & Sung-Hong Park & Gou Young Koh, 2019. "Meningeal lymphatic vessels at the skull base drain cerebrospinal fluid," Nature, Nature, vol. 572(7767), pages 62-66, August.
    • Handle: RePEc:nat:nature:v:572:y:2019:i:7767:d:10.1038_s41586-019-1419-5
    DOI: 10.1038/s41586-019-1419-5
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41586-019-1419-5
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/s41586-019-1419-5?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Dongyu Li & Shaojun Liu & Tingting Yu & Zhang Liu & Silin Sun & Denis Bragin & Alexander Shirokov & Nikita Navolokin & Olga Bragina & Zhengwu Hu & Jürgen Kurths & Ivan Fedosov & Inna Blokhina & Alexan, 2023. "Photostimulation of brain lymphatics in male newborn and adult rodents for therapy of intraventricular hemorrhage," Nature Communications, Nature, vol. 14(1), pages 1-20, December.
    2. Weiping Dai & Mengqian Yang & Pei Xia & Chuan Xiao & Shuying Huang & Zhan Zhang & Xin Cheng & Wenchang Li & Jian Jin & Jingyun Zhang & Binghuo Wu & Yingying Zhang & Pei-hui Wu & Yangyang Lin & Wen Wu , 2022. "A functional role of meningeal lymphatics in sex difference of stress susceptibility in mice," Nature Communications, Nature, vol. 13(1), pages 1-21, December.
    3. C. Siret & M. Lessen & J. Bavais & H. W. Jeong & S. K. Reddy Samawar & K. Kapupara & S. Wang & M. Simic & L. Fabritus & A. Tchoghandjian & M. Fallet & H. Huang & S. Sarrazin & M. H. Sieweke & R. Stumm, 2022. "Deciphering the heterogeneity of the Lyve1+ perivascular macrophages in the mouse brain," Nature Communications, Nature, vol. 13(1), pages 1-14, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:572:y:2019:i:7767:d:10.1038_s41586-019-1419-5. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.