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Structural and functional features of central nervous system lymphatic vessels

Author

Listed:
  • Antoine Louveau

    (Center for Brain Immunology and Glia, School of Medicine, University of Virginia
    School of Medicine, University of Virginia)

  • Igor Smirnov

    (Center for Brain Immunology and Glia, School of Medicine, University of Virginia
    School of Medicine, University of Virginia)

  • Timothy J. Keyes

    (Center for Brain Immunology and Glia, School of Medicine, University of Virginia
    School of Medicine, University of Virginia)

  • Jacob D. Eccles

    (Medical Scientist Training Program, School of Medicine, University of Virginia
    Beirne B. Carter Center for Immunology Research, School of Medicine, University of Virginia
    School of Medicine, University of Virginia)

  • Sherin J. Rouhani

    (Medical Scientist Training Program, School of Medicine, University of Virginia
    Beirne B. Carter Center for Immunology Research, School of Medicine, University of Virginia
    Immunology, and Cancer Biology, School of Medicine, University of Virginia)

  • J. David Peske

    (Medical Scientist Training Program, School of Medicine, University of Virginia
    Beirne B. Carter Center for Immunology Research, School of Medicine, University of Virginia
    Immunology, and Cancer Biology, School of Medicine, University of Virginia)

  • Noel C. Derecki

    (Center for Brain Immunology and Glia, School of Medicine, University of Virginia
    School of Medicine, University of Virginia)

  • David Castle

    (School of Medicine, University of Virginia)

  • James W. Mandell

    (School of Medicine, University of Virginia)

  • Kevin S. Lee

    (Center for Brain Immunology and Glia, School of Medicine, University of Virginia
    School of Medicine, University of Virginia
    School of Medicine, University of Virginia)

  • Tajie H. Harris

    (Center for Brain Immunology and Glia, School of Medicine, University of Virginia
    School of Medicine, University of Virginia)

  • Jonathan Kipnis

    (Center for Brain Immunology and Glia, School of Medicine, University of Virginia
    School of Medicine, University of Virginia
    Medical Scientist Training Program, School of Medicine, University of Virginia)

Abstract

The central nervous system undergoes constant immune surveillance, but the route that immune cells take to exit the brain has been unclear as it had been thought to lack a classical lymphatic drainage system; here functional lymphatic vessels able to carry both fluid and immune cells from the cerebrospinal fluid are shown to be located in the brain meninges.

Suggested Citation

  • Antoine Louveau & Igor Smirnov & Timothy J. Keyes & Jacob D. Eccles & Sherin J. Rouhani & J. David Peske & Noel C. Derecki & David Castle & James W. Mandell & Kevin S. Lee & Tajie H. Harris & Jonathan, 2015. "Structural and functional features of central nervous system lymphatic vessels," Nature, Nature, vol. 523(7560), pages 337-341, July.
    • Handle: RePEc:nat:nature:v:523:y:2015:i:7560:d:10.1038_nature14432
    DOI: 10.1038/nature14432
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    Cited by:

    1. Miao Wang & Congcong Yan & Xi Li & Tianhao Yang & Shengnan Wu & Qian Liu & Qingming Luo & Feifan Zhou, 2024. "Non-invasive modulation of meningeal lymphatics ameliorates ageing and Alzheimer’s disease-associated pathology and cognition in mice," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    2. Yogi H. Hendlin, 2022. "Plant Philosophy and Interpretation: Making Sense of Contemporary Plant Intelligence Debates," Environmental Values, , vol. 31(3), pages 253-276, June.
    3. Shelei Pan & Peter H. Yang & Dakota DeFreitas & Sruthi Ramagiri & Peter O. Bayguinov & Carl D. Hacker & Abraham Z. Snyder & Jackson Wilborn & Hengbo Huang & Gretchen M. Koller & Dhvanii K. Raval & Gra, 2023. "Gold nanoparticle-enhanced X-ray microtomography of the rodent reveals region-specific cerebrospinal fluid circulation in the brain," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    4. Hadi Abou-El-Hassan & Rafael M. Rezende & Saef Izzy & Galina Gabriely & Taha Yahya & Bruna K. Tatematsu & Karl J. Habashy & Juliana R. Lopes & Gislane L. V. Oliveira & Amir-Hadi Maghzi & Zhuoran Yin &, 2023. "Vγ1 and Vγ4 gamma-delta T cells play opposing roles in the immunopathology of traumatic brain injury in males," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
    5. Xiang He & Daiqin Xiong & Lei Zhao & Jialong Fu & Lingfei Luo, 2024. "Meningeal lymphatic supporting cells govern the formation and maintenance of zebrafish mural lymphatic endothelial cells," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    6. Shinji Naganawa & Yutaka Kato & Tadao Yoshida & Michihiko Sone, 2023. "Fluid signal suppression characteristics of 3D-FLAIR with a T2 selective inversion pulse in the skull base," Nature Communications, Nature, vol. 14(1), pages 1-3, December.
    7. Nicola A. Kearns & Artemis Iatrou & Daniel J. Flood & Sashini Tissera & Zachary M. Mullaney & Jishu Xu & Chris Gaiteri & David A. Bennett & Yanling Wang, 2023. "Dissecting the human leptomeninges at single-cell resolution," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    8. Dongyu Li & Shaojun Liu & Tingting Yu & Zhang Liu & Silin Sun & Denis Bragin & Alexander Shirokov & Nikita Navolokin & Olga Bragina & Zhengwu Hu & Jürgen Kurths & Ivan Fedosov & Inna Blokhina & Alexan, 2023. "Photostimulation of brain lymphatics in male newborn and adult rodents for therapy of intraventricular hemorrhage," Nature Communications, Nature, vol. 14(1), pages 1-20, December.
    9. Josephine A. Mapunda & Javier Pareja & Mykhailo Vladymyrov & Elisa Bouillet & Pauline Hélie & Petr Pleskač & Sara Barcos & Johanna Andrae & Dietmar Vestweber & Donald M. McDonald & Christer Betsholtz , 2023. "VE-cadherin in arachnoid and pia mater cells serves as a suitable landmark for in vivo imaging of CNS immune surveillance and inflammation," Nature Communications, Nature, vol. 14(1), pages 1-23, December.
    10. Per Kristian Eide & Aslan Lashkarivand & Are Pripp & Lars Magnus Valnes & Markus Herberg Hovd & Geir Ringstad & Kaj Blennow & Henrik Zetterberg, 2023. "Plasma neurodegeneration biomarker concentrations associate with glymphatic and meningeal lymphatic measures in neurological disorders," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    11. Anastasia Mozokhina & Rostislav Savinkov, 2020. "Mathematical Modelling of the Structure and Function of the Lymphatic System," Mathematics, MDPI, vol. 8(9), pages 1-18, September.
    12. Laura Bojarskaite & Alexandra Vallet & Daniel M. Bjørnstad & Kristin M. Gullestad Binder & Céline Cunen & Kjell Heuser & Miroslav Kuchta & Kent-Andre Mardal & Rune Enger, 2023. "Sleep cycle-dependent vascular dynamics in male mice and the predicted effects on perivascular cerebrospinal fluid flow and solute transport," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    13. Geir Ringstad & Per Kristian Eide, 2023. "The pitfalls of interpreting hyperintense FLAIR signal as lymph outside the human brain," Nature Communications, Nature, vol. 14(1), pages 1-3, December.
    14. Weiping Dai & Mengqian Yang & Pei Xia & Chuan Xiao & Shuying Huang & Zhan Zhang & Xin Cheng & Wenchang Li & Jian Jin & Jingyun Zhang & Binghuo Wu & Yingying Zhang & Pei-hui Wu & Yangyang Lin & Wen Wu , 2022. "A functional role of meningeal lymphatics in sex difference of stress susceptibility in mice," Nature Communications, Nature, vol. 13(1), pages 1-21, December.
    15. Per Kristian Eide & Geir Ringstad, 2024. "Functional analysis of the human perivascular subarachnoid space," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    16. Chou, Dean & Chen, Po-Yen, 2024. "A machine learning method to explore the glymphatic system via poroelastodynamics," Chaos, Solitons & Fractals, Elsevier, vol. 178(C).
    17. Carolin Beuker & David Schafflick & Jan-Kolja Strecker & Michael Heming & Xiaolin Li & Jolien Wolbert & Antje Schmidt-Pogoda & Christian Thomas & Tanja Kuhlmann & Irene Aranda-Pardos & Noelia A-Gonzal, 2022. "Stroke induces disease-specific myeloid cells in the brain parenchyma and pia," Nature Communications, Nature, vol. 13(1), pages 1-14, December.

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