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Bioprinting Technology in Skin, Heart, Pancreas and Cartilage Tissues: Progress and Challenges in Clinical Practice

Author

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  • Eleonora Di Piazza

    (Multifactorial and Complex Disease Research Area, Preventive and Predictive Medicine Unit, Bambino Gesù Children’s Hospital, IRCCS, 00146 Rome, Italy)

  • Elisabetta Pandolfi

    (Multifactorial and Complex Disease Research Area, Preventive and Predictive Medicine Unit, Bambino Gesù Children’s Hospital, IRCCS, 00146 Rome, Italy)

  • Ilaria Cacciotti

    (Engineering Department, Niccolò Cusano University of Rome, INSTM RU, 00166 Rome, Italy)

  • Andrea Del Fattore

    (Genetics and Rare Diseases Research Area, Bone Physiopathology Research Unit, Bambino Gesù Children’s Hospital, IRCCS, 00146 Rome, Italy)

  • Alberto Eugenio Tozzi

    (Multifactorial and Complex Disease Research Area, Preventive and Predictive Medicine Unit, Bambino Gesù Children’s Hospital, IRCCS, 00146 Rome, Italy)

  • Aurelio Secinaro

    (Clinical Management and Technological Innovations Area, Department of Imaging, Bambino Gesù Children’s Hospital, IRCCS, 00146 Rome, Italy)

  • Luca Borro

    (Clinical Management and Technological Innovations Area, Department of Imaging, Bambino Gesù Children’s Hospital, IRCCS, 00146 Rome, Italy)

Abstract

Bioprinting is an emerging additive manufacturing technique which shows an outstanding potential for shaping customized functional substitutes for tissue engineering. Its introduction into the clinical space in order to replace injured organs could ideally overcome the limitations faced with allografts. Presently, even though there have been years of prolific research in the field, there is a wide gap to bridge in order to bring bioprinting from “bench to bedside”. This is due to the fact that bioprinted designs have not yet reached the complexity required for clinical use, nor have clear GMP (good manufacturing practices) rules or precise regulatory guidelines been established. This review provides an overview of some of the most recent and remarkable achievements for skin, heart, pancreas and cartilage bioprinting breakthroughs while highlighting the critical shortcomings for each tissue type which is keeping this technique from becoming widespread reality.

Suggested Citation

  • Eleonora Di Piazza & Elisabetta Pandolfi & Ilaria Cacciotti & Andrea Del Fattore & Alberto Eugenio Tozzi & Aurelio Secinaro & Luca Borro, 2021. "Bioprinting Technology in Skin, Heart, Pancreas and Cartilage Tissues: Progress and Challenges in Clinical Practice," IJERPH, MDPI, vol. 18(20), pages 1-29, October.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:20:p:10806-:d:656682
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    References listed on IDEAS

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    1. Lei Jiang & Alexander A. Shestov & Pamela Swain & Chendong Yang & Seth J. Parker & Qiong A. Wang & Lance S. Terada & Nicholas D. Adams & Michael T. McCabe & Beth Pietrak & Stan Schmidt & Christian M. , 2016. "Reductive carboxylation supports redox homeostasis during anchorage-independent growth," Nature, Nature, vol. 532(7598), pages 255-258, April.
    2. Soon-Jung Park & Ri Youn Kim & Bong-Woo Park & Sunghun Lee & Seong Woo Choi & Jae-Hyun Park & Jong Jin Choi & Seok-Won Kim & Jinah Jang & Dong-Woo Cho & Hyung-Min Chung & Sung-Hwan Moon & Kiwon Ban & , 2019. "Dual stem cell therapy synergistically improves cardiac function and vascular regeneration following myocardial infarction," Nature Communications, Nature, vol. 10(1), pages 1-12, December.
    3. Susan Caroline Peirce & Grace Carolan-Rees, 2019. "ReCell® Spray-On Skin System for Treating Skin Loss, Scarring and Depigmentation after Burn Injury: A NICE Medical Technology Guidance," Applied Health Economics and Health Policy, Springer, vol. 17(2), pages 131-141, April.
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