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Distinct sub-second dopamine signaling in dorsolateral striatum measured by a genetically-encoded fluorescent sensor

Author

Listed:
  • Armando G. Salinas

    (National Institutes of Health
    George Mason University
    Louisiana State University Health Sciences Center – Shreveport)

  • Jeong Oen Lee

    (National Institutes of Health)

  • Shana M. Augustin

    (National Institutes of Health
    Department of Pharmacology, Northwestern University Feinberg School of Medicine)

  • Shiliang Zhang

    (National Institute on Drug Abuse)

  • Tommaso Patriarchi

    (University of California at Davis
    University of Zurich)

  • Lin Tian

    (University of California at Davis)

  • Marisela Morales

    (National Institute on Drug Abuse)

  • Yolanda Mateo

    (National Institutes of Health)

  • David M. Lovinger

    (National Institutes of Health)

Abstract

The development of genetically encoded dopamine sensors such as dLight has provided a new approach to measuring slow and fast dopamine dynamics both in brain slices and in vivo, possibly enabling dopamine measurements in areas like the dorsolateral striatum (DLS) where previously such recordings with fast-scan cyclic voltammetry (FSCV) were difficult. To test this, we first evaluated dLight photometry in mouse brain slices with simultaneous FSCV and found that both techniques yielded comparable results, but notable differences in responses to dopamine transporter inhibitors, including cocaine. We then used in vivo fiber photometry with dLight in mice to examine responses to cocaine in DLS. We also compared dopamine responses during Pavlovian conditioning across the striatum. We show that dopamine increases were readily detectable in DLS and describe transient dopamine kinetics, as well as slowly developing signals during conditioning. Overall, our findings indicate that dLight photometry is well suited to measuring dopamine dynamics in DLS.

Suggested Citation

  • Armando G. Salinas & Jeong Oen Lee & Shana M. Augustin & Shiliang Zhang & Tommaso Patriarchi & Lin Tian & Marisela Morales & Yolanda Mateo & David M. Lovinger, 2023. "Distinct sub-second dopamine signaling in dorsolateral striatum measured by a genetically-encoded fluorescent sensor," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
  • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-41581-3
    DOI: 10.1038/s41467-023-41581-3
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    References listed on IDEAS

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    1. Guohong Cui & Sang Beom Jun & Xin Jin & Michael D. Pham & Steven S. Vogel & David M. Lovinger & Rui M. Costa, 2013. "Concurrent activation of striatal direct and indirect pathways during action initiation," Nature, Nature, vol. 494(7436), pages 238-242, February.
    2. Ali Mohebi & Jeffrey R. Pettibone & Arif A. Hamid & Jenny-Marie T. Wong & Leah T. Vinson & Tommaso Patriarchi & Lin Tian & Robert T. Kennedy & Joshua D. Berke, 2019. "Dissociable dopamine dynamics for learning and motivation," Nature, Nature, vol. 570(7759), pages 65-70, June.
    3. Jeffrey E. Markowitz & Winthrop F. Gillis & Maya Jay & Jeffrey Wood & Ryley W. Harris & Robert Cieszkowski & Rebecca Scott & David Brann & Dorothy Koveal & Tomasz Kula & Caleb Weinreb & Mohammed Abdal, 2023. "Spontaneous behaviour is structured by reinforcement without explicit reward," Nature, Nature, vol. 614(7946), pages 108-117, February.
    4. Ali Mohebi & Jeffrey R. Pettibone & Arif A. Hamid & Jenny-Marie T. Wong & Leah T. Vinson & Tommaso Patriarchi & Lin Tian & Robert T. Kennedy & Joshua D. Berke, 2019. "Publisher Correction: Dissociable dopamine dynamics for learning and motivation," Nature, Nature, vol. 571(7763), pages 3-3, July.
    5. Mark W. Howe & Patrick L. Tierney & Stefan G. Sandberg & Paul E. M. Phillips & Ann M. Graybiel, 2013. "Prolonged dopamine signalling in striatum signals proximity and value of distant rewards," Nature, Nature, vol. 500(7464), pages 575-579, August.
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    1. Marie A. Labouesse & Maria Wilhelm & Zacharoula Kagiampaki & Andrew G. Yee & Raphaelle Denis & Masaya Harada & Andrea Gresch & Alina-Măriuca Marinescu & Kanako Otomo & Sebastiano Curreli & Laia Serrat, 2024. "A chemogenetic approach for dopamine imaging with tunable sensitivity," Nature Communications, Nature, vol. 15(1), pages 1-22, December.

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