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Continuous cholinergic-dopaminergic updating in the nucleus accumbens underlies approaches to reward-predicting cues

Author

Listed:
  • Miguel Skirzewski

    (Western University)

  • Oren Princz-Lebel

    (Western University
    Western University)

  • Liliana German-Castelan

    (Western University
    Western University)

  • Alycia M. Crooks

    (Western University
    Western University)

  • Gerard Kyungwook Kim

    (Western University
    University of Toronto)

  • Sophie Henke Tarnow

    (Western University
    Western University)

  • Amy Reichelt

    (Western University
    University of Adelaide)

  • Sara Memar

    (Western University)

  • Daniel Palmer

    (Western University
    Western University)

  • Yulong Li

    (Peking University School of Life Sciences)

  • R. Jane Rylett

    (Western University
    Western University)

  • Lisa M. Saksida

    (Western University
    Western University)

  • Vania F. Prado

    (Western University
    Western University
    Western University)

  • Marco A. M. Prado

    (Western University
    Western University
    Western University)

  • Timothy J. Bussey

    (Western University
    Western University)

Abstract

The ability to learn Pavlovian associations from environmental cues predicting positive outcomes is critical for survival, motivating adaptive behaviours. This cued-motivated behaviour depends on the nucleus accumbens (NAc). NAc output activity mediated by spiny projecting neurons (SPNs) is regulated by dopamine, but also by cholinergic interneurons (CINs), which can release acetylcholine and glutamate via the activity of the vesicular acetylcholine transporter (VAChT) or the vesicular glutamate transporter (VGLUT3), respectively. Here we investigated behavioural and neurochemical changes in mice performing a touchscreen Pavlovian approach task by recording dopamine, acetylcholine, and calcium dynamics from D1- and D2-SPNs using fibre photometry in control, VAChT or VGLUT3 mutant mice to understand how these signals cooperate in the service of approach behaviours toward reward-predicting cues. We reveal that NAc acetylcholine-dopaminergic signalling is continuously updated to regulate striatal output underlying the acquisition of Pavlovian approach learning toward reward-predicting cues.

Suggested Citation

  • Miguel Skirzewski & Oren Princz-Lebel & Liliana German-Castelan & Alycia M. Crooks & Gerard Kyungwook Kim & Sophie Henke Tarnow & Amy Reichelt & Sara Memar & Daniel Palmer & Yulong Li & R. Jane Rylett, 2022. "Continuous cholinergic-dopaminergic updating in the nucleus accumbens underlies approaches to reward-predicting cues," Nature Communications, Nature, vol. 13(1), pages 1-21, December.
  • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-35601-x
    DOI: 10.1038/s41467-022-35601-x
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    References listed on IDEAS

    as
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