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Concurrent activation of striatal direct and indirect pathways during action initiation

Author

Listed:
  • Guohong Cui

    (Section on In Vivo Neural Function, Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 5625 Fishers Lane, Bethesda, Maryland 20892-9412, USA)

  • Sang Beom Jun

    (Ewha Womans University, Seoul 120-750, Korea)

  • Xin Jin

    (Section on In Vivo Neural Function, Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 5625 Fishers Lane, Bethesda, Maryland 20892-9412, USA
    Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA)

  • Michael D. Pham

    (Section on In Vivo Neural Function, Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 5625 Fishers Lane, Bethesda, Maryland 20892-9412, USA)

  • Steven S. Vogel

    (Section on Cellular Biophotonics, Laboratory for Molecular Physiology, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 5625 Fishers Lane, Bethesda 20892-9412, Maryland, USA)

  • David M. Lovinger

    (Section on In Vivo Neural Function, Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 5625 Fishers Lane, Bethesda, Maryland 20892-9412, USA
    Section on Synaptic Pharmacology, Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 5625 Fishers Lane, Bethesda, Maryland 20892-9412, USA)

  • Rui M. Costa

    (Section on In Vivo Neural Function, Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 5625 Fishers Lane, Bethesda, Maryland 20892-9412, USA
    Champalimaud Neuroscience Programme at Instituto Gulbenkian de Ciência and Champalimaud Centre for the Unknown, Lisbon 1400-038, Portugal)

Abstract

In mice performing an operant task, increases in neural activity in direct- and indirect-pathway spiny projection neurons (SPNs) are associated with action initiation but not with inactivity, and concurrent activation of SPNs from both pathways in one hemisphere precedes the initiation of contraversive movements.

Suggested Citation

  • Guohong Cui & Sang Beom Jun & Xin Jin & Michael D. Pham & Steven S. Vogel & David M. Lovinger & Rui M. Costa, 2013. "Concurrent activation of striatal direct and indirect pathways during action initiation," Nature, Nature, vol. 494(7436), pages 238-242, February.
    • Handle: RePEc:nat:nature:v:494:y:2013:i:7436:d:10.1038_nature11846
    DOI: 10.1038/nature11846
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    Cited by:

    1. Himanshu Gangal & Xueyi Xie & Zhenbo Huang & Yifeng Cheng & Xuehua Wang & Jiayi Lu & Xiaowen Zhuang & Amanda Essoh & Yufei Huang & Ruifeng Chen & Laura N. Smith & Rachel J. Smith & Jun Wang, 2023. "Drug reinforcement impairs cognitive flexibility by inhibiting striatal cholinergic neurons," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    2. Miguel Skirzewski & Oren Princz-Lebel & Liliana German-Castelan & Alycia M. Crooks & Gerard Kyungwook Kim & Sophie Henke Tarnow & Amy Reichelt & Sara Memar & Daniel Palmer & Yulong Li & R. Jane Rylett, 2022. "Continuous cholinergic-dopaminergic updating in the nucleus accumbens underlies approaches to reward-predicting cues," Nature Communications, Nature, vol. 13(1), pages 1-21, December.
    3. Lizhu Li & Lihui Lu & Yuqi Ren & Guo Tang & Yu Zhao & Xue Cai & Zhao Shi & He Ding & Changbo Liu & Dali Cheng & Yang Xie & Huachun Wang & Xin Fu & Lan Yin & Minmin Luo & Xing Sheng, 2022. "Colocalized, bidirectional optogenetic modulations in freely behaving mice with a wireless dual-color optoelectronic probe," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    4. Armando G. Salinas & Jeong Oen Lee & Shana M. Augustin & Shiliang Zhang & Tommaso Patriarchi & Lin Tian & Marisela Morales & Yolanda Mateo & David M. Lovinger, 2023. "Distinct sub-second dopamine signaling in dorsolateral striatum measured by a genetically-encoded fluorescent sensor," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    5. Christophe Varin & Amandine Cornil & Delphine Houtteman & Patricia Bonnavion & Alban Kerchove d’Exaerde, 2023. "The respective activation and silencing of striatal direct and indirect pathway neurons support behavior encoding," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    6. Sean C. Piantadosi & Elizabeth E. Manning & Brittany L. Chamberlain & James Hyde & Zoe LaPalombara & Nicholas M. Bannon & Jamie L. Pierson & Vijay M. K Namboodiri & Susanne E. Ahmari, 2024. "Hyperactivity of indirect pathway-projecting spiny projection neurons promotes compulsive behavior," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    7. Maria Wilhelm & Yaroslav Sych & Aleksejs Fomins & José Luis Alatorre Warren & Christopher Lewis & Laia Serratosa Capdevila & Roman Boehringer & Elizabeth A. Amadei & Benjamin Grewe & Eoin C. O’Connor , 2023. "Striatum-projecting prefrontal cortex neurons support working memory maintenance," Nature Communications, Nature, vol. 14(1), pages 1-16, December.

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