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Prolonged dopamine signalling in striatum signals proximity and value of distant rewards

Author

Listed:
  • Mark W. Howe

    (Massachusetts Institute of Technology)

  • Patrick L. Tierney

    (Massachusetts Institute of Technology)

  • Stefan G. Sandberg

    (University of Washington)

  • Paul E. M. Phillips

    (University of Washington)

  • Ann M. Graybiel

    (Massachusetts Institute of Technology)

Abstract

Cyclic voltammetry reveals an extended mode of reward-predictive dopamine signalling in the striatum as rats navigate; signals increase as the rats approach distant rewards, instead of showing phasic or steady tonic activity, and the increases scale flexibly with the distance and size of the rewards.

Suggested Citation

  • Mark W. Howe & Patrick L. Tierney & Stefan G. Sandberg & Paul E. M. Phillips & Ann M. Graybiel, 2013. "Prolonged dopamine signalling in striatum signals proximity and value of distant rewards," Nature, Nature, vol. 500(7464), pages 575-579, August.
    • Handle: RePEc:nat:nature:v:500:y:2013:i:7464:d:10.1038_nature12475
    DOI: 10.1038/nature12475
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    Citations

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    Cited by:

    1. Ayaka Kato & Kenji Morita, 2016. "Forgetting in Reinforcement Learning Links Sustained Dopamine Signals to Motivation," PLOS Computational Biology, Public Library of Science, vol. 12(10), pages 1-41, October.
    2. Seetha Krishnan & Chad Heer & Chery Cherian & Mark E. J. Sheffield, 2022. "Reward expectation extinction restructures and degrades CA1 spatial maps through loss of a dopaminergic reward proximity signal," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
    3. Eleanor Holton & Jan Grohn & Harry Ward & Sanjay G. Manohar & Jill X. O’Reilly & Nils Kolling, 2024. "Goal commitment is supported by vmPFC through selective attention," Nature Human Behaviour, Nature, vol. 8(7), pages 1351-1365, July.
    4. Miguel Á. Luján & Dan P. Covey & Reana Young-Morrison & LanYuan Zhang & Andrew Kim & Fiorella Morgado & Sachin Patel & Caroline E. Bass & Carlos Paladini & Joseph F. Cheer, 2023. "Mobilization of endocannabinoids by midbrain dopamine neurons is required for the encoding of reward prediction," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    5. Sravani Kondapavulur & Stefan M. Lemke & David Darevsky & Ling Guo & Preeya Khanna & Karunesh Ganguly, 2022. "Transition from predictable to variable motor cortex and striatal ensemble patterning during behavioral exploration," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    6. Allen P. F. Chen & Jeffrey M. Malgady & Lu Chen & Kaiyo W. Shi & Eileen Cheng & Joshua L. Plotkin & Shaoyu Ge & Qiaojie Xiong, 2022. "Nigrostriatal dopamine pathway regulates auditory discrimination behavior," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    7. Min Jung Kim & Daniel J. Gibson & Dan Hu & Tomoko Yoshida & Emily Hueske & Ayano Matsushima & Ara Mahar & Cynthia J. Schofield & Patlapa Sompolpong & Kathy T. Tran & Lin Tian & Ann M. Graybiel, 2024. "Dopamine release plateau and outcome signals in dorsal striatum contrast with classic reinforcement learning formulations," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
    8. Armando G. Salinas & Jeong Oen Lee & Shana M. Augustin & Shiliang Zhang & Tommaso Patriarchi & Lin Tian & Marisela Morales & Yolanda Mateo & David M. Lovinger, 2023. "Distinct sub-second dopamine signaling in dorsolateral striatum measured by a genetically-encoded fluorescent sensor," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    9. Kazutaka Maeda & Ken-ichi Inoue & Masahiko Takada & Okihide Hikosaka, 2023. "Environmental context-dependent activation of dopamine neurons via putative amygdala-nigra pathway in macaques," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    10. Laurens Winkelmeier & Carla Filosa & Renée Hartig & Max Scheller & Markus Sack & Jonathan R. Reinwald & Robert Becker & David Wolf & Martin Fungisai Gerchen & Alexander Sartorius & Andreas Meyer-Linde, 2022. "Striatal hub of dynamic and stabilized prediction coding in forebrain networks for olfactory reinforcement learning," Nature Communications, Nature, vol. 13(1), pages 1-21, December.
    11. Abigail Kalmbach & Vanessa Winiger & Nuri Jeong & Arun Asok & Charles R. Gallistel & Peter D. Balsam & Eleanor H. Simpson, 2022. "Dopamine encodes real-time reward availability and transitions between reward availability states on different timescales," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    12. Lior Matityahu & Naomi Gilin & Gideon A. Sarpong & Yara Atamna & Lior Tiroshi & Nicolas X. Tritsch & Jeffery R. Wickens & Joshua A. Goldberg, 2023. "Acetylcholine waves and dopamine release in the striatum," Nature Communications, Nature, vol. 14(1), pages 1-23, December.

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