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PET-measured human dopamine synthesis capacity and receptor availability predict trading rewards and time-costs during foraging

Author

Listed:
  • Angela M. Ianni

    (Clinical & Translational Neuroscience Branch, National Institutes of Mental Health, Intramural Research Program, National Institutes of Health
    University of Oxford
    University of Pittsburgh)

  • Daniel P. Eisenberg

    (Clinical & Translational Neuroscience Branch, National Institutes of Mental Health, Intramural Research Program, National Institutes of Health)

  • Erie D. Boorman

    (University of Oxford)

  • Sara M. Constantino

    (New York University
    Northeastern University
    Northeastern University
    Princeton University)

  • Catherine E. Hegarty

    (Clinical & Translational Neuroscience Branch, National Institutes of Mental Health, Intramural Research Program, National Institutes of Health)

  • Michael D. Gregory

    (Clinical & Translational Neuroscience Branch, National Institutes of Mental Health, Intramural Research Program, National Institutes of Health)

  • Joseph C. Masdeu

    (Clinical & Translational Neuroscience Branch, National Institutes of Mental Health, Intramural Research Program, National Institutes of Health
    Houston Methodist Institute for Academic Medicine
    Weill Cornell Medicine)

  • Philip D. Kohn

    (Clinical & Translational Neuroscience Branch, National Institutes of Mental Health, Intramural Research Program, National Institutes of Health)

  • Timothy E. Behrens

    (University of Oxford)

  • Karen F. Berman

    (Clinical & Translational Neuroscience Branch, National Institutes of Mental Health, Intramural Research Program, National Institutes of Health)

Abstract

Foraging behavior requires weighing costs of time to decide when to leave one reward patch to search for another. Computational and animal studies suggest that striatal dopamine is key to this process; however, the specific role of dopamine in foraging behavior in humans is not well characterized. We use positron emission tomography (PET) imaging to directly measure dopamine synthesis capacity and D1 and D2/3 receptor availability in 57 healthy adults who complete a computerized foraging task. Using voxelwise data and principal component analysis to identify patterns of variation across PET measures, we show that striatal D1 and D2/3 receptor availability and a pattern of mesolimbic and anterior cingulate cortex dopamine function are important for adjusting the threshold for leaving a patch to explore, with specific sensitivity to changes in travel time. These findings suggest a key role for dopamine in trading reward benefits against temporal costs to modulate behavioral adaptions to changes in the reward environment critical for foraging.

Suggested Citation

  • Angela M. Ianni & Daniel P. Eisenberg & Erie D. Boorman & Sara M. Constantino & Catherine E. Hegarty & Michael D. Gregory & Joseph C. Masdeu & Philip D. Kohn & Timothy E. Behrens & Karen F. Berman, 2023. "PET-measured human dopamine synthesis capacity and receptor availability predict trading rewards and time-costs during foraging," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-41897-0
    DOI: 10.1038/s41467-023-41897-0
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    References listed on IDEAS

    as
    1. Ali Mohebi & Jeffrey R. Pettibone & Arif A. Hamid & Jenny-Marie T. Wong & Leah T. Vinson & Tommaso Patriarchi & Lin Tian & Robert T. Kennedy & Joshua D. Berke, 2019. "Dissociable dopamine dynamics for learning and motivation," Nature, Nature, vol. 570(7759), pages 65-70, June.
    2. Neil Garrett & Nathaniel D. Daw, 2020. "Biased belief updating and suboptimal choice in foraging decisions," Nature Communications, Nature, vol. 11(1), pages 1-12, December.
    3. Ali Mohebi & Jeffrey R. Pettibone & Arif A. Hamid & Jenny-Marie T. Wong & Leah T. Vinson & Tommaso Patriarchi & Lin Tian & Robert T. Kennedy & Joshua D. Berke, 2019. "Publisher Correction: Dissociable dopamine dynamics for learning and motivation," Nature, Nature, vol. 571(7763), pages 3-3, July.
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