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Immunophenotypic correlates of sustained MRD negativity in patients with multiple myeloma

Author

Listed:
  • David G. Coffey

    (University of Miami
    Fred Hutchinson Cancer Research Center)

  • Francesco Maura

    (University of Miami)

  • Edgar Gonzalez-Kozlova

    (Icahn School of Medicine at Mount Sinai)

  • J. Javier Diaz-Mejia

    (University Health Network)

  • Ping Luo

    (University Health Network)

  • Yong Zhang

    (U.S. Food and Drug Administration)

  • Yuexin Xu

    (Fred Hutchinson Cancer Research Center)

  • Edus H. Warren

    (Fred Hutchinson Cancer Research Center)

  • Travis Dawson

    (Icahn School of Medicine at Mount Sinai)

  • Brian Lee

    (Icahn School of Medicine at Mount Sinai)

  • Hui Xie

    (Icahn School of Medicine at Mount Sinai)

  • Eric Smith

    (Dana-Farber Cancer Institute)

  • Amanda Ciardiello

    (Memorial Sloan Kettering Cancer Center)

  • Hearn J. Cho

    (Icahn School of Medicine at Mount Sinai
    Multiple Myeloma Research Foundation)

  • Adeeb Rahman

    (Icahn School of Medicine at Mount Sinai)

  • Seunghee Kim-Schulze

    (Icahn School of Medicine at Mount Sinai)

  • Benjamin Diamond

    (University of Miami)

  • Alexander Lesokhin

    (Memorial Sloan Kettering Cancer Center)

  • Dickran Kazandjian

    (University of Miami)

  • Trevor J. Pugh

    (University Health Network
    Ontario Institute for Cancer Research
    University of Toronto)

  • Damian J. Green

    (Fred Hutchinson Cancer Research Center)

  • Sacha Gnjatic

    (Icahn School of Medicine at Mount Sinai)

  • Ola Landgren

    (University of Miami)

Abstract

The role of the immune microenvironment in maintaining disease remission in patients with multiple myeloma (MM) is not well understood. In this study, we comprehensively profile the immune system in patients with newly diagnosed MM receiving continuous lenalidomide maintenance therapy with the aim of discovering correlates of long-term treatment response. Leveraging single-cell RNA sequencing and T cell receptor β sequencing of the peripheral blood and CyTOF mass cytometry of the bone marrow, we longitudinally characterize the immune landscape in 23 patients before and one year after lenalidomide exposure. We compare patients achieving sustained minimal residual disease (MRD) negativity to patients who never achieved or were unable to maintain MRD negativity. We observe that the composition of the immune microenvironment in both the blood and the marrow varied substantially according to both MRD negative status and history of autologous stem cell transplant, supporting the hypothesis that the immune microenvironment influences the depth and duration of treatment response.

Suggested Citation

  • David G. Coffey & Francesco Maura & Edgar Gonzalez-Kozlova & J. Javier Diaz-Mejia & Ping Luo & Yong Zhang & Yuexin Xu & Edus H. Warren & Travis Dawson & Brian Lee & Hui Xie & Eric Smith & Amanda Ciard, 2023. "Immunophenotypic correlates of sustained MRD negativity in patients with multiple myeloma," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-40966-8
    DOI: 10.1038/s41467-023-40966-8
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    References listed on IDEAS

    as
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