IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v12y2021i1d10.1038_s41467-021-26951-z.html
   My bibliography  Save this article

Subclone-specific microenvironmental impact and drug response in refractory multiple myeloma revealed by single‐cell transcriptomics

Author

Listed:
  • Stephan M. Tirier

    (Division of Chromatin Networks, German Cancer Research Center (DKFZ) and Bioquant)

  • Jan-Philipp Mallm

    (Division of Chromatin Networks, German Cancer Research Center (DKFZ) and Bioquant
    Single Cell Open Lab, German Cancer Research Center (DKFZ) and Bioquant
    Molecular Precision Oncology Program, NCT Heidelberg)

  • Simon Steiger

    (Division of Chromatin Networks, German Cancer Research Center (DKFZ) and Bioquant)

  • Alexandra M. Poos

    (University Hospital Heidelberg, Internal Medicine V
    CCU Molecular Hematology/Oncology, German Cancer Research Center (DKFZ))

  • Mohamed H. S. Awwad

    (University Hospital Heidelberg, Internal Medicine V)

  • Nicola Giesen

    (University Hospital Heidelberg, Internal Medicine V
    CCU Molecular Hematology/Oncology, German Cancer Research Center (DKFZ))

  • Nicola Casiraghi

    (Division of Computational Genomics and System Genetics, German Cancer Research Center (DKFZ)
    European Molecular Biology Laboratory (EMBL), Genome Biology Unit)

  • Hana Susak

    (Division of Computational Genomics and System Genetics, German Cancer Research Center (DKFZ)
    European Molecular Biology Laboratory (EMBL), Genome Biology Unit)

  • Katharina Bauer

    (Single Cell Open Lab, German Cancer Research Center (DKFZ) and Bioquant
    Molecular Precision Oncology Program, NCT Heidelberg)

  • Anja Baumann

    (CCU Molecular Hematology/Oncology, German Cancer Research Center (DKFZ))

  • Lukas John

    (University Hospital Heidelberg, Internal Medicine V
    CCU Molecular Hematology/Oncology, German Cancer Research Center (DKFZ))

  • Anja Seckinger

    (University Hospital Heidelberg, Internal Medicine V
    Department of Hematology and Immunology, Myeloma Center Brussels)

  • Dirk Hose

    (University Hospital Heidelberg, Internal Medicine V
    Department of Hematology and Immunology, Myeloma Center Brussels)

  • Carsten Müller-Tidow

    (University Hospital Heidelberg, Internal Medicine V)

  • Hartmut Goldschmidt

    (University Hospital Heidelberg, Internal Medicine V
    National Center for Tumor Diseases (NCT))

  • Oliver Stegle

    (Division of Computational Genomics and System Genetics, German Cancer Research Center (DKFZ)
    European Molecular Biology Laboratory (EMBL), Genome Biology Unit)

  • Michael Hundemer

    (University Hospital Heidelberg, Internal Medicine V)

  • Niels Weinhold

    (University Hospital Heidelberg, Internal Medicine V
    CCU Molecular Hematology/Oncology, German Cancer Research Center (DKFZ))

  • Marc S. Raab

    (University Hospital Heidelberg, Internal Medicine V
    CCU Molecular Hematology/Oncology, German Cancer Research Center (DKFZ))

  • Karsten Rippe

    (Division of Chromatin Networks, German Cancer Research Center (DKFZ) and Bioquant)

Abstract

Relapsed/refractory multiple myeloma (RRMM) is characterized by a remarkable heterogeneity and high drug resistance. Here, the authors analyse RRMM samples by single-cell RNA-sequencing, revealing molecular features associated with high-risk chromosomal 1q-gain and changes in the tumor microenvironment.

Suggested Citation

  • Stephan M. Tirier & Jan-Philipp Mallm & Simon Steiger & Alexandra M. Poos & Mohamed H. S. Awwad & Nicola Giesen & Nicola Casiraghi & Hana Susak & Katharina Bauer & Anja Baumann & Lukas John & Anja Sec, 2021. "Subclone-specific microenvironmental impact and drug response in refractory multiple myeloma revealed by single‐cell transcriptomics," Nature Communications, Nature, vol. 12(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-26951-z
    DOI: 10.1038/s41467-021-26951-z
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-021-26951-z
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-021-26951-z?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Robert J. Johnston & Linhui Julie Su & Jason Pinckney & David Critton & Eric Boyer & Arathi Krishnakumar & Martin Corbett & Andrew L. Rankin & Rose Dibella & Lynne Campbell & Gaelle H. Martin & Hadia , 2019. "VISTA is an acidic pH-selective ligand for PSGL-1," Nature, Nature, vol. 574(7779), pages 565-570, October.
    2. Tomofumi Uto & Tomohiro Fukaya & Hideaki Takagi & Keiichi Arimura & Takeshi Nakamura & Naoya Kojima & Bernard Malissen & Katsuaki Sato, 2016. "Clec4A4 is a regulatory receptor for dendritic cells that impairs inflammation and T-cell immunity," Nature Communications, Nature, vol. 7(1), pages 1-15, September.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. David G. Coffey & Francesco Maura & Edgar Gonzalez-Kozlova & J. Javier Diaz-Mejia & Ping Luo & Yong Zhang & Yuexin Xu & Edus H. Warren & Travis Dawson & Brian Lee & Hui Xie & Eric Smith & Amanda Ciard, 2023. "Immunophenotypic correlates of sustained MRD negativity in patients with multiple myeloma," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    2. Lukas John & Alexandra M. Poos & Alexander Brobeil & Carolina Schinke & Stefanie Huhn & Nina Prokoph & Raphael Lutz & Barbara Wagner & Maurizio Zangari & Stephan M. Tirier & Jan-Philipp Mallm & Sabrin, 2023. "Resolving the spatial architecture of myeloma and its microenvironment at the single-cell level," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    3. Aleksandr Ianevski & Kristen Nader & Kyriaki Driva & Wojciech Senkowski & Daria Bulanova & Lidia Moyano-Galceran & Tanja Ruokoranta & Heikki Kuusanmäki & Nemo Ikonen & Philipp Sergeev & Markus Vähä-Ko, 2024. "Single-cell transcriptomes identify patient-tailored therapies for selective co-inhibition of cancer clones," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    4. Travis S. Johnson & Parvathi Sudha & Enze Liu & Nathan Becker & Sylvia Robertson & Patrick Blaney & Gareth Morgan & Vivek S. Chopra & Cedric Santos & Michael Nixon & Kun Huang & Attaya Suvannasankha &, 2024. "1q amplification and PHF19 expressing high-risk cells are associated with relapsed/refractory multiple myeloma," Nature Communications, Nature, vol. 15(1), pages 1-15, December.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Jing Fu & Shirong Li & Huihui Ma & Jun Yang & Gabriel M. Pagnotti & Lewis M. Brown & Stephen J. Weiss & Markus Y. Mapara & Suzanne Lentzsch, 2023. "The checkpoint inhibitor PD-1H/VISTA controls osteoclast-mediated multiple myeloma bone disease," Nature Communications, Nature, vol. 14(1), pages 1-14, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-26951-z. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.