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Subclone-specific microenvironmental impact and drug response in refractory multiple myeloma revealed by single‐cell transcriptomics

Author

Listed:
  • Stephan M. Tirier

    (Division of Chromatin Networks, German Cancer Research Center (DKFZ) and Bioquant)

  • Jan-Philipp Mallm

    (Division of Chromatin Networks, German Cancer Research Center (DKFZ) and Bioquant
    Single Cell Open Lab, German Cancer Research Center (DKFZ) and Bioquant
    Molecular Precision Oncology Program, NCT Heidelberg)

  • Simon Steiger

    (Division of Chromatin Networks, German Cancer Research Center (DKFZ) and Bioquant)

  • Alexandra M. Poos

    (University Hospital Heidelberg, Internal Medicine V
    CCU Molecular Hematology/Oncology, German Cancer Research Center (DKFZ))

  • Mohamed H. S. Awwad

    (University Hospital Heidelberg, Internal Medicine V)

  • Nicola Giesen

    (University Hospital Heidelberg, Internal Medicine V
    CCU Molecular Hematology/Oncology, German Cancer Research Center (DKFZ))

  • Nicola Casiraghi

    (Division of Computational Genomics and System Genetics, German Cancer Research Center (DKFZ)
    European Molecular Biology Laboratory (EMBL), Genome Biology Unit)

  • Hana Susak

    (Division of Computational Genomics and System Genetics, German Cancer Research Center (DKFZ)
    European Molecular Biology Laboratory (EMBL), Genome Biology Unit)

  • Katharina Bauer

    (Single Cell Open Lab, German Cancer Research Center (DKFZ) and Bioquant
    Molecular Precision Oncology Program, NCT Heidelberg)

  • Anja Baumann

    (CCU Molecular Hematology/Oncology, German Cancer Research Center (DKFZ))

  • Lukas John

    (University Hospital Heidelberg, Internal Medicine V
    CCU Molecular Hematology/Oncology, German Cancer Research Center (DKFZ))

  • Anja Seckinger

    (University Hospital Heidelberg, Internal Medicine V
    Department of Hematology and Immunology, Myeloma Center Brussels)

  • Dirk Hose

    (University Hospital Heidelberg, Internal Medicine V
    Department of Hematology and Immunology, Myeloma Center Brussels)

  • Carsten Müller-Tidow

    (University Hospital Heidelberg, Internal Medicine V)

  • Hartmut Goldschmidt

    (University Hospital Heidelberg, Internal Medicine V
    National Center for Tumor Diseases (NCT))

  • Oliver Stegle

    (Division of Computational Genomics and System Genetics, German Cancer Research Center (DKFZ)
    European Molecular Biology Laboratory (EMBL), Genome Biology Unit)

  • Michael Hundemer

    (University Hospital Heidelberg, Internal Medicine V)

  • Niels Weinhold

    (University Hospital Heidelberg, Internal Medicine V
    CCU Molecular Hematology/Oncology, German Cancer Research Center (DKFZ))

  • Marc S. Raab

    (University Hospital Heidelberg, Internal Medicine V
    CCU Molecular Hematology/Oncology, German Cancer Research Center (DKFZ))

  • Karsten Rippe

    (Division of Chromatin Networks, German Cancer Research Center (DKFZ) and Bioquant)

Abstract

Relapsed/refractory multiple myeloma (RRMM) is characterized by a remarkable heterogeneity and high drug resistance. Here, the authors analyse RRMM samples by single-cell RNA-sequencing, revealing molecular features associated with high-risk chromosomal 1q-gain and changes in the tumor microenvironment.

Suggested Citation

  • Stephan M. Tirier & Jan-Philipp Mallm & Simon Steiger & Alexandra M. Poos & Mohamed H. S. Awwad & Nicola Giesen & Nicola Casiraghi & Hana Susak & Katharina Bauer & Anja Baumann & Lukas John & Anja Sec, 2021. "Subclone-specific microenvironmental impact and drug response in refractory multiple myeloma revealed by single‐cell transcriptomics," Nature Communications, Nature, vol. 12(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-26951-z
    DOI: 10.1038/s41467-021-26951-z
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    References listed on IDEAS

    as
    1. Tomofumi Uto & Tomohiro Fukaya & Hideaki Takagi & Keiichi Arimura & Takeshi Nakamura & Naoya Kojima & Bernard Malissen & Katsuaki Sato, 2016. "Clec4A4 is a regulatory receptor for dendritic cells that impairs inflammation and T-cell immunity," Nature Communications, Nature, vol. 7(1), pages 1-15, September.
    2. Robert J. Johnston & Linhui Julie Su & Jason Pinckney & David Critton & Eric Boyer & Arathi Krishnakumar & Martin Corbett & Andrew L. Rankin & Rose Dibella & Lynne Campbell & Gaelle H. Martin & Hadia , 2019. "VISTA is an acidic pH-selective ligand for PSGL-1," Nature, Nature, vol. 574(7779), pages 565-570, October.
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    Cited by:

    1. David G. Coffey & Francesco Maura & Edgar Gonzalez-Kozlova & J. Javier Diaz-Mejia & Ping Luo & Yong Zhang & Yuexin Xu & Edus H. Warren & Travis Dawson & Brian Lee & Hui Xie & Eric Smith & Amanda Ciard, 2023. "Immunophenotypic correlates of sustained MRD negativity in patients with multiple myeloma," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    2. Lukas John & Alexandra M. Poos & Alexander Brobeil & Carolina Schinke & Stefanie Huhn & Nina Prokoph & Raphael Lutz & Barbara Wagner & Maurizio Zangari & Stephan M. Tirier & Jan-Philipp Mallm & Sabrin, 2023. "Resolving the spatial architecture of myeloma and its microenvironment at the single-cell level," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    3. Travis S. Johnson & Parvathi Sudha & Enze Liu & Nathan Becker & Sylvia Robertson & Patrick Blaney & Gareth Morgan & Vivek S. Chopra & Cedric Santos & Michael Nixon & Kun Huang & Attaya Suvannasankha &, 2024. "1q amplification and PHF19 expressing high-risk cells are associated with relapsed/refractory multiple myeloma," Nature Communications, Nature, vol. 15(1), pages 1-15, December.

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